Rakhi Pandey

Enhancing Proteomics Quality Control: Insights from the Visualization Tool QCeltis

Manasa Vegesna, Niveda Sundararaman, Ajay Bharadwaj, Kirstin Washington et autres

Large-scale mass-spectrometry-based proteomics experiments are complex and prone to analytical variability, requiring rigorous quality checks across each step in the workflow: sample preparation, chromatography, mass spectrometry, and the bioinformatics stages. This includes quality control (QC) measures that address biological and technical variation. …

us (code pays fourni par la source)

Disease related changes in ATAC-seq of iPSC-derived motor neuron lines from ALS patients and controls

Stanislav Tsitkov, Kelsey Valentine, Velina Kozareva, Aneesh Donde et autres

Amyotrophic Lateral Sclerosis (ALS), like many other neurodegenerative diseases, is highly heritable, but with only a small fraction of cases explained by monogenic disease alleles. To better understand sporadic ALS, we report epigenomic profiles, as measured by ATAC-seq, of motor neuron cultures …

us (code pays fourni par la source)

Peptidyl arginine deiminase inhibition alleviates angiotensin II-induced fibrosis.

Takeshi Ijichi, Niveda Sundararaman, Thomas G. Martin, Rakhi Pandey et autres

OBJECTIVES: The conversion of protein arginine residues to citrulline by calcium-dependent peptidyl arginine deiminases (PADs) has been implicated in the pathogenesis of several diseases, indicating that PADs are therapeutic targets. A recent study indicated that PAD4 regulates age-related organ fibrosis and dysfunction; …

jp, us (code pays fourni par la source)

Protein arginine deiminase 2 (PAD2) modulates the polarization of THP-1 macrophages to the anti-inflammatory M2 phenotype

Aneta Stachowicz, Rakhi Pandey, Niveda Sundararaman, Vidya Venkatraman et autres

BACKGROUND: Macrophages are effector cells of the innate immune system that undergo phenotypical changes in response to organ injury and repair. These cells are most often classified as proinflammatory M1 and anti-inflammatory M2 macrophages. Protein arginine deiminase (PAD), which catalyses the irreversible …

pl, us (code pays fourni par la source)

Identifying patterns in amyotrophic lateral sclerosis progression from sparse longitudinal data

Divya Ramamoorthy, Kristen Severson, Soumya Ghosh, Karen Sachs et autres

The clinical presentation of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease, varies widely across patients, making it challenging to determine if potential therapeutics slow progression. We sought to determine whether there were common patterns of disease progression that could aid in …

us (code pays fourni par la source)

Answer ALS, a large-scale resource for sporadic and familial ALS combining clinical and multi-omics data from induced pluripotent cell lines

Emily G. Baxi, Terri G. Thompson, Jonathan C. Li, Julia Kaye et autres

Answer ALS is a biological and clinical resource of patient-derived, induced pluripotent stem (iPS) cell lines, multi-omic data derived from iPS neurons and longitudinal clinical and smartphone data from over 1,000 patients with ALS. This resource provides population-level biological and clinical data …

us (code pays fourni par la source)

Additional file 4 of Protein arginine deiminase 2 (PAD2) modulates the polarization of THP-1 macrophages to the anti-inflammatory M2 phenotype

Aneta Stachowicz, Rakhi Pandey, Niveda Sundararaman, Vidya Venkatraman et autres

Additional file 4: Supplemental Table 3 A. All citrullinated peptides quantified in THP-1 macrophages polarized to M1 and M2 phenotype in the presence of BB-Cl-amidine. Supplemental Table 3 B. All citrullinated peptides quantified in LPS stimulated THP-1 macrophages with silenced PAD2.

pl, us (code pays fourni par la source)

Additional file 2 of Protein arginine deiminase 2 (PAD2) modulates the polarization of THP-1 macrophages to the anti-inflammatory M2 phenotype

Aneta Stachowicz, Rakhi Pandey, Niveda Sundararaman, Vidya Venkatraman et autres

Additional file 2: Supplemental Table 1 A. Differentially expressed proteins in THP-1 macrophages treated with BB-Cl-amidine as compared to control group (q < 0.05, n = 5). Supplemental Table 1 B. Differentially expressed proteins in THP-1 macrophages treated with LPS as compared …

pl, us (code pays fourni par la source)

Additional file 3 of Protein arginine deiminase 2 (PAD2) modulates the polarization of THP-1 macrophages to the anti-inflammatory M2 phenotype

Aneta Stachowicz, Rakhi Pandey, Niveda Sundararaman, Vidya Venkatraman et autres

Additional file 3: Supplemental Table 2 A. Differentially expressed proteins in THP-1 macrophages with silenced PAD2 as compared to scrambled siRNA control group (q < 0.05, n = 6). Supplemental Table 2 B. Differentially expressed proteins in THP-1 macrophages with silenced PAD2 …

pl, us (code pays fourni par la source)

Discovery Proteomics for COVID-19: Where We Are Now

Angela McArdle, Kirstin E. Washington, Blandine Chazarin Orgel, Aleksandra Binek et autres

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible coronavirus responsible for the pandemic coronavirus disease 2019 (COVID-19), which has had a devastating impact on society. Here, we summarize proteomic research that has helped elucidate hallmark proteins associated with the …

us (code pays fourni par la source)

Prevalence of Work-Related Stress and Addiction Due To It among Indians

Ravi Shankar Kumar, Divyam Sharma, Sufiya Khan, Somya Singh et autres

Work Related Stress (WRS) is one of the common types of mental health and stress disorder among Indian that affects the physical, psychological as well as social health of people and has the capability to lead a person to different kinds of …

in (code pays fourni par la source)

Answer ALS: A Large-Scale Resource for Sporadic and Familial ALS Combining Clinical Data with Multi-Omics Data from Induced Pluripotent Cell Lines

Jeffrey D. Rothstein, James D. Berry, Clive Niels Svendsen, Leslie Michels Thompson et autres

us, mx, ru (code pays fourni par la source)