Ryou Kubota

Supramolecular morphological transition driven by nonequilibrium break-and-build self-organisation

Ryou Kubota, Yuriki Ikuta, Shogo Torigoe, Naoki Kanazawa et autres

Controlling the nonequilibrium dynamics in synthetic systems is an important challenge in supramolecular chemistry. Biological morphogenesis exploits nonequilibrium reaction–diffusion processes to organise differentiated cell networks and functions in space. In contrast, artificial assemblies are mostly formed under thermodynamic control, and they thus …

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自己集合性ジペプチドと界面活性剤からなる超分子ファイバーのcryo-TEM像

Ryou Kubota

jp (code pays fourni par la source)

コアセルベートのナノ構造TEM像

Ryou Kubota

jp (code pays fourni par la source)

Nonequilbrium Dynamics of Stimulus Responsive Supramolecular Hydrogels

Ryou Kubota

1．刺激応答性超分子ヒドロゲル

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Supramolecular Morphogenesis Driven by Nonequilibrium Break-and-Build Self-organisation

Ryou Kubota, Yuriki Ikuta, Shogo Torigoe, Itaru Hamachi

Controlling the nonequilibrium dynamics in synthetic systems is an important challenge in supramolecular chemistry. Biological morphogenesis exploits nonequilibrium reaction–diffusion processes to organise differentiated cell networks and functions in space. In contrast, artificial assemblies are mostly formed under thermodynamic control, and they thus …

jp (code pays fourni par la source)

A minimalist design approach to simple coacervates from low-molecular-weight components

Ryou Kubota

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Emergence of Dynamic Instability by Hybridizing Synthetic Self-Assembled Dipeptide Fibers with Surfactant Micelles

Shogo Torigoe, Kazutoshi Nagao, Ryou Kubota, Itaru Hamachi

Supramolecular chemistry currently faces the challenge of controlling nonequilibrium dynamics such as the dynamic instability of microtubules. In this study, we explored the emergence of dynamic instability through the hybridization of peptide-type supramolecular nanofibers with surfactant micelles. Using real-time confocal imaging, we …

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Cell‐Like Synthetic Supramolecular Soft Materials Realized in Multicomponent, Non‐/Out‐of‐Equilibrium Dynamic Systems

Ryou Kubota, Itaru Hamachi

Living cells are complex, nonequilibrium supramolecular systems capable of independently and/or cooperatively integrating multiple bio-supramolecules to execute intricate physiological functions that cannot be accomplished by individual biomolecules. These biological design strategies offer valuable insights for the development of synthetic supramolecular systems with …

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Visualizing Formation and Dynamics of a Three-Dimensional Sponge-like Network of a Coacervate in Real Time

Ryou Kubota, Taro Hiroi, Yuriki Ikuta, Yuchong Liu et autres

Coacervates, which are formed by liquid–liquid phase separation, have been extensively explored as models for synthetic cells and membraneless organelles, so their in-depth structural analysis is crucial. However, both the inner structure dynamics and formation mechanism of coacervates remain elusive. Herein, we …

jp (code pays fourni par la source)

Supramolecular–Polymer Composite Hydrogels: From In Situ Network Observation to Functional Properties

Ryou Kubota

Abstract Living cells and organisms are composed of numerous biomolecules and control their concentrations and spatial distribution in a spatiotemporal manner to exhibit intricate biological functions. Inspired by the extracellular matrix, synthetic multi-network hydrogels have attracted attention due to their remarkable properties …

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Four distinct network patterns of supramolecular/polymer composite hydrogels controlled by formation kinetics and interfiber interactions

K. Nakamura, Ryou Kubota, Takuma Aoyama, Kenji Urayama et autres

Synthetic composite hydrogels comprising supramolecular fibers and covalent polymers have attracted considerable attention because their properties are similar to biological connective tissues. However, an in-depth analysis of the network structures has not been performed. In this study, we discovered the composite network …

jp (code pays fourni par la source)

Visualizing formation and dynamics of a three-dimensional sponge-like network of a coacervate in real time

Ryou Kubota, Taro Hiroi, Yuchong Liu, Itaru Hamachi

Coacervates, which are formed by liquid–liquid phase separation, have been extensively explored as models for synthetic cells and membraneless organelles, so their in-depth structural analysis is crucial. However, both the inner structure dynamics and formation mechanism of coacervates remain elusive. Herein, we …

jp (code pays fourni par la source)