Riham A. El‐Shiekh

Phytochemical profiling of Olea europaea subsp. cuspidata aerial parts using LC-DAD-QToF: cholinesterase inhibition and molecular docking insights into potential Alzheimer’s disease targets

Riham A. El‐Shiekh, Asmaa A. Mandour, Essam Abdel‐Sattar, Nermeen B. Ali

Olea europaea subsp. cuspidata is traditionally used in African medicine, but its phytochemical composition and cholinesterase inhibitory activity have not been comprehensively investigated. This study evaluated the cholinesterase inhibitory activity and phytochemical profile of the methanolic extract of O. europaea aerial parts, …

Égypte (code pays fourni par la source)

Potential wound healing effects of Combretum aculeatum Vent. aerial parts; FOXO1/MIP2 modulation supported by LC-QTOF-MS/MS and molecular docking approaches

Mai E. Hussein, Manal Sabry, Ahlam M. El-Fishawy, Basma M. Eltanany et autres

Égypte (code pays fourni par la source)

Unraveling potent therapeutic potentials of tanshinones, lipophilic abietane diterpenes: a holistic literature review

Shymaa I. A. Abdel-dayem, Rania M. Kamal, Heba R. Ghaiad, Mariam K. Ahmed et autres

Tanshinones, a class of lipophilic abietane-type diterpenoid, represents the major bioactive constituents of Salvia miltiorrhiza Bunge (Danshen), a key herb in traditional Chinese medicine with growing therapeutic importance. This review offers an in-depth overview of tanshinones from phytochemical and pharmacological perspectives. The …

Égypte, nl (code pays fourni par la source)

Phytocompounds with immunomodulatory activities: mechanisms, therapeutic potential, and clinical prospects

Noha A. Mehana, Nourhan Ibrahim Morad, Rehab Mekky, Amal M. Mahfoz et autres

The immune system is essential for host defense, immune surveillance, and maintenance of physiological homeostasis; its dysregulation underlies a broad spectrum of disorders, including autoimmune, inflammatory, infectious, neoplastic, and immunodeficiency diseases. Despite advances in modern immunotherapy, current treatments remain limited by suboptimal …

Égypte, sa (code pays fourni par la source)

Kaempferol: advances in biosynthesis, molecular mechanisms, and therapeutic applications

Eman S. Zaki, Miral O. Sabry, Fatma I. Abou-Elazm, Ahmed M. El-Dessouki et autres

Égypte, sg (code pays fourni par la source)

Diosmin-Capped Silver Nanoparticles Promote Osteogenic Differentiation of Human Periodontal Ligament Stem Cells: Box–Behnken Optimization and in vitro Evaluation

Roxane Abdel-Gawad, Shymaa Hatem, Nehal I. Rizk, Shereen N. Raafat et autres

Aim: Diosmin is a bioactive flavonoid with anti-inflammatory, anti-oxidant, and osteogenic properties; however, its poor water solubility limits its therapeutic use. To overcome this, the study developed Diosmin-loaded silver nanoparticles (AgNPs), leveraging the bone-regenerative potential of silver, as a unique strategy to …

Égypte (code pays fourni par la source)

Natural compounds targeting inflammatory signaling and cell adhesion molecules in ischemic acute kidney injury

Sally A. Fahim, Ahmed M. El-Dessouki, Nada Osama, Sherif S. Abdel Mageed et autres

Ischemic acute kidney injury (AKI) remains a major clinical challenge, characterized by high morbidity, mortality, and a substantial risk of progression to chronic kidney disease. Accumulating evidence indicates that ischemic AKI is not merely a transient hemodynamic disorder but a complex, biologically …

Égypte, ae, kr (code pays fourni par la source)

A comprehensive review on ethnobotany, phytochemistry, traditional and modern uses of chasteberry (Vitex agnus-castus L.)

Shaza H. Aly, Noha N. Nasr, Riham A. El‐Shiekh, Shymaa Hatem et autres

Abstract Vitex agnus-castus L. (chaste tree) has a rich history of use in traditional medicine across various cultures for over 2500 years, particularly for gynecological issues. Its applications range from regulating menstrual cycles to alleviating premenstrual syndrome and menopausal symptoms, with endorsements …

Égypte, iq (code pays fourni par la source)

Decoding the mechanistic basis of liver–muscle communication in health and disease

Noha M. Gamil, Habiba A. Elsayed, Esraa T. Salah, Heba A. Mostafa et autres

The bidirectional communication between liver and skeletal muscle represents a critical yet underexplored axis in human physiology. Dysfunction in either organ can accelerate pathology in the other, amplifying disease progression. Understanding this interconnected system is essential for developing targeted and effective therapeutic …

Égypte (code pays fourni par la source)

Therapeutic Potentials of Girinimbine, A Carbazole Alkaloid: A Review

Shymaa I. A. Abdel-dayem, Sally A. Fahim, Ahmed M. El-Dessouki, Riham A. El‐Shiekh et autres

Égypte, ae (code pays fourni par la source)

Natural Non-carbohydrate Prebiotic Candidate: In Vitro and In Vivo Insights into Their Therapeutic Potential

Doha K. Hussein, Mona M. Okba, Dina Abou-Hussein, Riham A. El‐Shiekh et autres

Égypte (code pays fourni par la source)

Impact of endoplasmic reticulum (ER) stress on cellular functions and role of natural products as modulators

Mai A. Abd-Elmawla, Heba R. Ghaiad, Youmna M. Abd Elbaqy, Mohamed Bakr Zaki et autres

Abstract Background The endoplasmic reticulum (ER) is a dynamic and essential cell organelle involved in the synthesis and correct folding of secretory and membrane-bounded proteins, as well as in preserving intracellular Ca 2+ equilibrium. Main body During cellular stress, the deposition of …

Égypte, sa (code pays fourni par la source)