Aimee V. Chappelow

An RCS-Like Retinal Dystrophy Phenotype in Mer Knockout Mice

Glenn K. Matsushima, Douglas Yasumura, Nikolaus Trautmann, Matthew M. LaVail et autres

PURPOSE. To determine whether mice that are homozygous for a targeted disruption of the Mer receptor tyrosine kinase gene (merkd) manifest a retinal dystrophy phenotype similar to RCS rats, which carry a mutation in the orthologous gene Mertk. METHODS. Eyes of merkdand …

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Predictors of visual acuity and genotype-phenotype correlates in a cohort of patients with Stargardt disease

Virginia Miraldi Utz, Razek Georges Coussa, Meghan J. Marino, Aimee V. Chappelow et autres

PURPOSE: To assess the genotypic diversity in patients with Stargardt disease and to characterise epidemiological and genotypic predictors of phenotype. METHODS: Retrospective, cross-sectional study of 112 patients with Stargardt disease. We evaluated the correlation between age at presentation, best-corrected visual acuity (BCVA), …

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Identification of Three ABCA4 Sequence Variations Exclusive to African American Patients in a Cohort of Patients With Stargardt Disease

Virginia Miraldi Utz, Aimee V. Chappelow, Meghan J. Marino, Craig D. Beight et autres

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Uveal Melanoma: Brachytherapy

Aimee V. Chappelow, Arun D. Singh, Chris S. Bergstrom

ABCA4 Genotypic Diversity And Phenotypic Correlates In Stargardt Disease

Virginia Miraldi Utz, Aimee V. Chappelow, Susan Crowe, Gayle J. T. Pauer et autres

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Reply

Aimee V. Chappelow, Kevin Tan, Peter K. Kaiser, Nadia Khalida Waheed

Stargardt Disease

Aimee V. Chappelow, Elias I. Traboulsi

Abstract Autosomal recessive Stargardt disease and fundus flavimaculatus represent a single clinical entity caused by mutation of the ABCA4 gene and accumulation of defective gene product (A2E) at the level of the RPE. The autosomal dominant STGD3 phenotype results when a mutation …

Panretinal Photocoagulation for Proliferative Diabetic Retinopathy: Pattern Scan Laser Versus Argon Laser

Aimee V. Chappelow, Kevin Tan, Nadia Khalida Waheed, Peter K. Kaiser

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Acute Postoperative Endophthalmitis in a Patient with Darier’s Disease

Aimee V. Chappelow, Gregory S. Kosmorsky, Craig D. Lewis, Julian D. Perry

A 58-year-old man with Darier's disease developed endophthalmitis 3 days following left-sided cataract extraction with intraocular lens implantation. Vitreous cultures were positive for Pseudomonas aeruginosa, similar to previously cultured hyperkeratotic plaques on the patient. Despite emergent vitrectomy and aggressive treatment with systemic, …

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Granulomatous Orbital Inflammation Associated with Intraorbital Titanium-Impregnated Acetate Fiber

Aimee V. Chappelow, James Tanner McMahon, Curtiss L. Jones, G S Kosmorsky

Herein we report a 52-year-old man with subacute right-sided proptosis and diffuse intraconal enhancing abnormality on MRI. Orbital biopsy revealed granulomatous inflammation consistent with idiopathic orbital inflammatory syndrome (IOIS), or orbital pseudotumor. However, further examination under polarizing light microscopy also revealed acetate …

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Treatment of choroidal melanoma

Aimee V. Chappelow, ANDREW P. SCHACHAT

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Neovascular age-related macular degeneration

Aimee V. Chappelow, ANDREW P. SCHACHAT