Anna Casartelli

Predictive determinants of response to biological therapy in children and adults with severe asthma

Debora Maria Spitaleri, Marina Saad, Anna Casartelli, Giada Lazzaroni et autres

Background: The introduction of biological therapies in severe asthma (SA) has revolutionized its management. However, predictors of clinical response and treatable traits in children and adults are still poorly investigated. Aim: To identify determinants of clinical response in pediatric and adult patients …

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Improvement in health-related quality of life questionnaires with biologic treatment in severe asthma and comorbid chronic rhinosinusitis with or without nasal polyposis: a real-life experience

Pierachille Santus, Marina Saad, Anna Casartelli, Rosaria Lorusso et autres

BACKGROUND: Patients with severe asthma frequently have comorbid chronic rhinosinusitis (CRS) with or without nasal polyps, that can increase the symptom burden and complicate treatment. Real-life clinical data on the impact of biologic treatments on CRS-specific quality-of-life questionnaires are still lacking. MATERIALS …

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Inhalation from different pulmonary volumes does not impact bronchodilator efficacy in COPD patients

Camilla Zilianti, Lisa Milani, Linda Pelosi, Camilo Signorello et autres

Patients with Chronic Obstructive Pulmonary Disease (COPD) are typically instructed to inhale bronchodilators (BD) after a full deflation to residual volume (RV), a manoeuvre requiring coordination and effort. However, so far, no study has demonstrated superior BD efficacy when inhalation starts from …

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Prevalence of Immune-mediated Inflammatory Diseases in Patients with Lung Cancer

Marina Saad, Francesca Mandurino Mirizzi, Anna Casartelli, Debora Maria Spitaleri et autres

Background: Lung cancer is the leading cause of cancer death worldwide. Cigarette smoke remains the leading risk factor. In the last years, the association between immune-mediated inflammatory diseases (IMIDs) and bowel and hematological malignancies has been increasingly studied, but data on lung …

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Could biological disease modifying anti rheumatic drugs (bDMARDs) and small molecules have a key role in preventing COVID-19 infection?

Fiammetta Danzo, M Saad, S O'Donnell, D Spitaleri et autres

Background: The clinical manifestations of COVID-19 infection are very heterogeneous. Rheumatic patients should be more susceptible to develop severe forms of COVID-19 pneumonia due to an unbalanced immune response and treatment immunodepressants (disease modifying anti rheumatic drugs-DMARDs). Aims and objectives: To investigate …

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Prevalence and predictors of hypoxemia and chronic respiratory failure in stable COPD patients

G Croce, Sarah O'Donnell, E Franceschi, Stefano Pini et autres

Background: Hypoxemia and respiratory failure (RF) in chronic obstructive pulmonary disease (COPD) are associated with exacerbations, comorbidities and increased mortality. To date, the prevalence of hypoxemia and RF in stable COPD is unknown. We aimed to investigate the prevalence and determine specific …