Accès ouvert
2026
article
OpenAlex
Vanessa Magdalena Swiatek, Tom Tobias Kummer, Conrad-Jakob Swiatek, Lea Ehrhardt et autres
Background/Objectives: Aneurysmal subarachnoid hemorrhage (aSAH) carries high morbidity and mortality, with delayed cerebral ischemia (DCI) as a major secondary complication. Although infection has increasingly been implicated in DCI pathogenesis, the role of central nervous system (CNS) infection remains unclear. We evaluated CNS …
de
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Accès ouvert
2026
article
OpenAlex
Lea Ehrhardt, Georg Hille, Ehsan Amini, Alexey Surov et autres
PURPOSE: This study investigates possible differences of female and male patients' data in regard to the prediction of mortality and troponin level of acute pulmonary embolism (APE) patients. Radiomics features are utilized to gain insights of sex-specific image properties, which should support …
de
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Accès ouvert
2026
article
OpenAlex
Vanessa Magdalena Swiatek, Conrad-Jakob Schiffner, Tom Tobias Kummer, Lea Ehrhardt et autres
Background/Objectives: Delayed cerebral ischemia (DCI) is a major cause of poor outcome after aneurysmal subarachnoid hemorrhage (aSAH). Beyond large-vessel vasospasm, DCI reflects a systemic, multifactorial process involving inflammation, hematologic dysregulation, and organ dysfunction. Stroke-associated pneumonia (SAP), a frequent aSAH complication linked to …
de
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Accès ouvert
2025
article
OpenAlex
Lea Ehrhardt, Patrique Fiedler, Alexey Surov, Sylvia Saalfeld
PURPOSE: This study evaluates radiomics correlation with mortality and suitability as prognostic indicator for troponin for pulmonary embolism to enhance prognostic accuracy and guide personalized treatment strategies with the help of machine learning. We conducted an initial study focusing on texture information …
de
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Accès ouvert
2018
article
OpenAlex
Sandra Korge, Bert Maier, Franziska Brüning, Lea Ehrhardt et autres
Circadian clocks are molecular timekeeping mechanisms that allow organisms to anticipate daily changes in their environment. The fundamental cellular basis of these clocks is delayed negative feedback gene regulation with PERIOD and CRYPTOCHROME containing protein complexes as main inhibitory elements. For a …
de
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Accès ouvert
2017
article
OpenAlex
Judit Meyer-Kovac, Isa Kolbe, Lea Ehrhardt, Alexei Leliavski et autres
Objective Circadian Clock gene mutant mice show dampened 24-h feeding rhythms and an increased sensitivity to high-fat diet (HFD) feeding. Restricting HFD access to the dark phase counteracts its obesogenic effect in wild-type mice. The extent to which altered feeding rhythms are …
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Accès ouvert
2016
preprint
OpenAlex
Katrin B. Gehring, Karin Heufelder, Janina Feige, Paul W. Bauer et autres
The transcription factor cAMP-response element-binding protein (CREB) is involved in neuronal plasticity. Phosphorylation activates CREB and an increased level of phosphorylated CREB is regarded as an indicator of CREB-dependent transcriptional activation. In honeybees(Apis mellifera)we recently demonstrated a particular high abundance of the …
de
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