William Valdar

Systems genetics analysis reveals immune mediators of coronavirus disease severity in mice

Ellen L Risemberg, Sarah R Leist, Alexandra Schäfer, Kalika D. Kamat et autres

Severe disease following infection with SARS-CoV or SARS-CoV-2 is driven in part by genetically regulated immune responses that promote lung injury. To study genetic mechanisms of immune-mediated coronavirus pathogenesis, we screened the Collaborative Cross (CC) panel for Mus musculus strains that are …

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DetectGxT: detecting gene-by-treatment interactions on molecular count phenotypes accounting for allelic additivity

Yuriko Harigaya, Michael I. Love, William Valdar

Motivation: Identifying the mechanisms by which genetic variants affect the molecular response to an applied treatment is important across multiple biological fields, and an effective approach to this end is interaction molecular QTL mapping. However, the statistical models commonly used to detect …

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Genetic mapping in collaborative cross mouse strains identifies loci that affect initial sensitivity to cocaine

Sarah A. Schoenrock, Christiann H. Gaines, Lisa M. Tarantino, Joseph Farrington et autres

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Genetic mapping in collaborative cross mouse strains identifies loci that affect initial sensitivity to cocaine

Sarah A. Schoenrock, Christiann H. Gaines, Padam Kumar, Saad Khan et autres

RATIONALE: Cocaine use disorder (CUD) is a significant health concern that has devastating impacts on affected individuals and society. There are currently no approved therapies to treat CUD due, in part, to significant gaps in our knowledge about the underlying factors that …

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The impact of early-life exposures on growth and adult gut microbiome composition is dependent on genetic strain and parent- of- origin

M. Nazmul Huda, Emer Kelly, Keri Barron, Jing Xue et autres

BACKGROUND: Early-life exposure to environmental factors can have long-lasting impacts on offspring health into adulthood and therefore is an emerging public health concern. In particular, the impact of maternal environmental exposures such as diet and antibiotic use on the establishment of the …

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Probabilistic classification of gene-by-treatment interactions on molecular count phenotypes.

Jason L. Stein, Jordan M. Valone, Michael I Love, Yuriko Harigaya et autres

Genetic variation can modulate response to treatment (G×T) or environmental stimuli (G×E), both of which may be highly consequential in biomedicine. An effective approach to identifying G×T signals and gaining insight into molecular mechanisms is mapping quantitative trait loci (QTL) of molecular …

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A mutation in Themis contributes to anaphylaxis severity following oral peanut challenge in CC027 mice

Marta C Cruz Cisneros, Johanna M. Smeekens, Brea K. Hampton, A. Wesley Burks et autres

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Probabilistic classification of gene-by-treatment interactions on molecular count phenotypes

Yuriko Harigaya, Nana Matoba, Brandon D. Le, Jordan M. Valone et autres

Genetic variation can modulate response to treatment (G×T) or environmental stimuli (G×E), both of which can be highly consequential in biomedicine. An effective approach to identifying G×T signals and gaining insight into molecular mechanisms is mapping quantitative trait loci (QTL) of molecular …

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Genetic mapping in Collaborative Cross mouse strains identifies loci that affect initial sensitivity to cocaine

Sarah A. Schoenrock, Christiann H. Gaines, Priya A. Kumar, Shahid M. Khan et autres

ABSTRACT We identified two Collaborative Cross (CC) strains, CC004/TauUncJ (CC004) and CC041/TauUncJ (CC041), that differ significantly for locomotor response and self-administration of cocaine. In the current study, we crossed each of these strains to C57BL/6NJ (B6N) mice to produce two F2 populations …

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Probabilistic classification of gene-by-treatment interactions on molecular count phenotypes

Yuriko Harigaya, Nana Matoba, Brandon D. Le, Jordan M. Valone et autres

Abstract Genetic variation can modulate response to treatment (G×T) or environmental stimuli (G×E), both of which may be highly consequential in biomedicine. An effective approach to identifying G×T signals and gaining insight into molecular mechanisms is mapping quantitative trait loci (QTL) of …

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Sarbecovirus disease susceptibility is conserved across viral and host models

Baric R.S, Shaw G.D, William Valdar, Miller D.R et autres

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Sarbecovirus disease susceptibility is conserved across viral and host models

Sarah R. Leist, Alexandra Schäfer, Ellen L Risemberg, Timothy A. Bell et autres

century: SARS, MERS and COVID-19. The severity of the ongoing COVID-19 pandemic and increasing likelihood of future coronavirus outbreaks motivates greater understanding of factors leading to severe coronavirus disease. We screened ten strains from the Collaborative Cross mouse genetic reference panel and …

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