Zhuoer Chen

Microbial Production of Alternative Proteins for Food Applications: Advances, Industrial Challenges, and Regulatory Status

Zewei Lu, Zhuoer Chen, Dianqi Yang, Akhmad Awaludin Agustiar et autres

The escalating global population and the environmentally inefficient nature of livestock-based protein production are intensifying demand for sustainable and scalable protein alternatives. Microbial biosynthesis, employing engineered cell factories, represents a pivotal strategy for producing functional proteins with a reduced ecological footprint. This …

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Elucidating the Mechanism of Interactions Between Aminoglycosides and AuNPs: Why the Classical Colorimetric Assay May Falsely Report Aptamer Affinity

Yaning Liang, Shiyi Fang, Zhuoer Chen, Yuzhuo Chen et autres

Gold nanoparticles (AuNPs) are widely used in aptasensors because of their high extinction coefficient and aggregation-dependent color differences. However, recent studies have indicated that nonspecific interactions between target molecules and AuNPs may dominate the detection signal rather than aptamer-target specific binding. This …

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Hemoglobin secretion in Pichia pastoris via integration site and expression strength optimization

Zewei Lu, Zhuoer Chen, Xiaoqiang Ma

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A modular single- and dual-gene expression toolkit for Kluyveromyces marxianus

Zewei Lu, Chenyan Lv, Zhuoer Chen, Zhiwei Zhu et autres

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Biochemical characterization and optimized production of Vigna angularis hemoglobin in Pichia pastoris

Zewei Lu, Chenyan Lv, Zhuoer Chen, Dianqi Yang et autres

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DFT Reveals Adenine Adsorption on Graphene Oxide and AuNPs: A Potential Reason for Failure in Aptamer Selection

Zhuoer Chen, Qingqing Yang, Ying Yang, Tao Le

With the advancement of aptamer, an increasing number of SELEX methods have been developed. However, not all methods can effectively and efficiently enrich aptamer sequences. Recent studies have shown that GO-SELEX and Gold-SELEX methods barely enrich adenosine aptamers, likely due to the …

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Rethinking the Role of AuNPs in Colorimetric Aptasensors: Dominant Nonspecific Interactions with Antibiotics over Aptamer Recognition

Zhuoer Chen, Ying Yang, Xinge Cui, Luwei Chai et autres

Gold nanoparticles (AuNPs) have been widely used in aptasensors due to the distinct color differences between their dispersed and aggregated states. However, recent studies have revealed that such colorimetric signals may originate from direct interactions between small molecule targets and AuNPs, rather …

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When simulations meet reality: a critical analysis of conformational accuracy in DNA aptamer-target interactions

Zhuoer Chen, Ying Yang, Shuang Jiang, Yuzhuo Chen et autres

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Aptamer-based lateral flow strip for rapid detection of AFB1 in peanuts, soybeans, corn, and rice

Sixian Wang, Zhuoer Chen, Shuang Jiang, Xiaoling Zheng et autres

Aflatoxin B1 (AFB1), a Group 1 carcinogenic mycotoxin, poses a significant threat to human health by contaminating crops. It is urgent to establish a simple and rapid detection method to promptly identify the risk of AFB1 residues, thereby mitigating its adverse health …

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A Label-Free Aptasensor for the Detection of Sulfaquinoxaline Using AuNPs and Aptamer in Water Environment

Zhaoyang Zhou, Xingyue Chen, Shuang Jiang, Zhuoer Chen et autres

Sulfaquinoxaline (SQX) is widely utilized in aquaculture and animal husbandry due to its broad antimicrobial spectrum and low cost. However, it is difficult to degrade, and there are relevant residues in the aquatic environment, which could be harmful to both the ecological …

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A Label-Free Aptasensor for the Detection of Sulfaquinoxaline Using AuNPs and Aptamer in Water Environment

Zhaoyang Zhou, Xingyue Chen, Shuang Jiang, Zhuoer Chen et autres

Sulfaquinoxaline (SQX) is used extensively in aquaculture and animal husbandry due to its broad antimicrobial spectrum and low cost. However, it is difficult to degrade and there are relevant residues in the aquatic environment, which could be harmful to both the ecological …

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A comprehensive review on the pretreatment and detection methods of nitrofurans and their metabolites in animal-derived food and environmental samples

Xiaoling Zheng, Yong Qi Xie, Zhuoer Chen, Mingdong Cao et autres

In recent years, the residues of nitrofurans (NFs) and their metabolites in animal-derived food and environmental samples have gained widespread attention. The parent drugs and their metabolites have displayed significant toxicity to human health including carcinogenic, mutagenic and teratogenic effects, leading to …

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