Accès ouvert
2024
article
OpenAlex
Sapir Nachum, Evelin Sheinberger-Chorni, Sarit Zomer-Polak, Meital Cohen et autres
E2F8 is a transcriptional repressor that antagonizes E2F1 at the crossroads of the cell cycle, apoptosis, and cancer. Previously, we discovered that E2F8 is a direct target of the APC/C ubiquitin ligase. Nevertheless, it remains unknown how E2F8 is dynamically controlled throughout …
us
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Accès ouvert
2021
preprint
OpenAlex
Einat Panet, Ohad Kraus, Irit Shoval, Roxane Lahmi et autres
il
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Accès ouvert
2021
book-chapter
OpenAlex
Danit Wasserman, Sapir Nachum, Meirav Noach-Hirsh, Naomi Auerbach et autres
il, us
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Accès ouvert
2020
article
OpenAlex
Danit Wasserman, Sapir Nachum, Meital Cohen, Taylor P. Enrico et autres
We uncovered interlocking mechanisms regulating the temporal proteolysis of the transcriptional repressor E2F8 in cycling cells including SCF Cyclin F in G2, dephosphorylation of Cdk1 sites, and activation of APC/C Cdh1 , but not APC/C Cdc20 during mitotic exit and G1. Differential …
il, us
(code pays fourni par la source)
Accès ouvert
2019
preprint
OpenAlex
Danit Wasserman, Sapir Nachum, Meital Cohen, Taylor P. Enrico et autres
Abstract E2F8 is a transcriptional repressor that antagonizes the canonical cell cycle transcription factor E2F1. Despite the importance of this atypical E2F family member in cell cycle, apoptosis and cancer, we lack a complete description of the mechanisms that control its dynamics. …
il, us
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Accès ouvert
2019
article
OpenAlex
Hadas Nevenzal, Meirav Noach-Hirsh, Or Skornik-Bustan, Lev Brio et autres
Autophosphorylation of receptor and non-receptor tyrosine kinases is a common molecular switch with broad implications for pathogeneses and therapy of cancer and other human diseases. Technologies for large-scale discovery and analysis of autophosphorylation are limited by the inherent difficulty to distinguish between …
il
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2017
article
OpenAlex
Einat Panet, Tal Mashriki, Roxane Lahmi, Avi Jacob et autres
il
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Accès ouvert
2014
article
OpenAlex
Yaara Sharaby, Roxane Lahmi, Omer Amar, Idan Elbaz et autres
il
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2014
article
OpenAlex
Reut Barak, Roxane Lahmi, Lada Gevorkyan‐Airapetov, Eliad Levy et autres
il
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Accès ouvert
2013
article
OpenAlex
Tal Pe’er, Roxane Lahmi, Yaara Sharaby, Evelin Chorni et autres
Growth arrest-specific 2-like protein 3 (Gas2l3) was recently identified as an Actin/Tubulin cross-linker protein that regulates cytokinesis. Using cell-free systems from both frog eggs and human cells, we show that the Gas2l3 protein is targeted for ubiquitin-mediated proteolysis by the APC/C(Cdh1) complex, …
il, us
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Accès ouvert
2009
article
OpenAlex
S. Noy-Lotan, Orly Dgany, Roxane Lahmi, Nathaly Marcoux et autres
BACKGROUND: Congenital dyserythropoietic anemia type I is an inherited autosomal recessive macrocytic anemia associated with ineffective erythropoiesis and the development of secondary hemochromatosis. Distinct erythroid precursors with internuclear chromatin bridges and spongy heterochromatin are pathognomonic for the disease. The mutated gene (CDAN1) …
il, us
(code pays fourni par la source)
2008
article
OpenAlex
Sharon Noy‐Lotan, Orly Dgany, Roxane Lahmi, Nathaly Marcoux et autres
Abstract Congenital dyserythropoietic anemia (CDA) type I is an inherited autosomal recessive macrocytic anemia associated with ineffective erythropoiesis and the development of secondary hemochromatosis. Distinct erythroid precursors with inter-nuclear chromatin bridges and spongy heterochromatin are pathognomonic for the disease. The mutated gene …
il, us
(code pays fourni par la source)