Miguel Tolentino

Cerebrospinal fluid biomarkers as predictors of multiple sclerosis severity

Miguel Tolentino, Francesca Pace, Dana C. Perantie, Robert Mikesell et autres

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Randomised controlled trial of intermittent calorie restriction in people with multiple sclerosis

Laura Ghezzi, Valeria Tosti, Lisa Shi, Claudia Cantoni et autres

Background Calorie restriction (CR) ameliorates preclinical models of multiple sclerosis (MS) via multiple mechanisms. These include decreased leptin, a proinflammatory adipokine, but mechanistic studies in humans are lacking. Tests of daily and intermittent CR (iCR) in people with MS (pwMS) showed improvements …

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Effects of photobiomodulation therapy on muscle function in individuals with multiple sclerosis

Mitra Rouhani, Miguel Tolentino, Jeri‐Anne Lyons, Alexander V. Ng

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RANDOMIZED CONTROLLED TRIAL OF INTERMITTENT CALORIE RESTRICTION IN PEOPLE WITH MULTIPLE SCLEROSIS

Laura Ghezzi, Valeria Tosti, Lisa Shi, Claudia Cantoni et autres

ABSTRACT Background Calorie restriction (CR) ameliorates preclinical models of multiple sclerosis (MS) through reduction of inflammation. The aim of this trial was to study the effects of 12-week iCR on metabolic, immunological and clinical outcomes in people with MS (pwMS). Methods Participants …

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Randomized Clinical Trial of Intermittent Calorie Restriction in People with Multiple Sclerosis: Effects on Immunometabolic and Cognitive Measures

Miguel Tolentino, Laura Ghezzi, Valeria Tosti, Claudia Cantoni et autres

Abstract BACKGROUND Intermittent calorie restriction (iCR) reduces inflammation in preclinical models and in people with Multiple Sclerosis (pwMS). Mechanisms could be related to changes in levels of adipose tissue-derived adipokines with reduced systemic inflammation and gut microbiota composition. AIMS Evaluate the effects …

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Photobiomodulation at 830 nm Reduced Nitrite Production by Peripheral Blood Mononuclear Cells Isolated from Multiple Sclerosis Subjects

Miguel Tolentino, Chi C. Cho, Jeri‐Anne Lyons

Background: Multiple sclerosis (MS) is a neurodegenerative condition characterized by high concentration of nitric oxide leading to the production of reactive oxygen species (ROS) and reactive nitrogen species (RNS), a condition known as nitrosative stress. ROS and RNS produce the inhibition of …

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Photobiomodulation Modulates Interleukin-10 and Interferon Gamma Production by Mononuclear Cells from Healthy Donors and Persons with Multiple Sclerosis

Miguel Tolentino, Chi C. Cho, Jeri‐Anne Lyons

Background: Photobiomodulation (PBM) therapy was previously shown to reduce the clinical severity of disease and modulated pro- and anti-inflammatory cytokines in an animal model of multiple sclerosis (MS). Objective: Previous observations were extended to determine the effect of PBM therapy on peripheral …

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Chronic Effect Of Photobiomodulation Therapy On Muscle Function In Persons With Multiple Sclerosis

Mitra Rouhani, Miguel Tolentino, Erik Queoff, Chris Cho et autres

Muscle weakness and fatigue are two disabling symptoms of Multiple Sclerosis (MS). Photobiomodulation therapy (PBMT) using red/near-infrared light is an emerging therapeutic modality thought to improve endurance or strength in healthy populations. Previously presented work revealed that a single acute high energy …

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Acute Effects Of Photobiomodulation Therapy On Muscle Force Recovery In Persons With Multiple Sclerosis

Mitra Rouhani, Miguel Tolentino, Erik Queoff, Chris Cho et autres

Symptomatic fatigue, as well as muscle fatigue, are common in persons with multiple sclerosis (PwMS), and both can negatively affect quality of life (QOL). Photobiomodulation Therapy (PBMT), comprising light in a 600-1000 nm bandwidth, is an emerging therapeutic modality thought to enhance …

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Photobiomodulation (PBM) regulates nitric oxide (NO) production by peripheral blood mononuclear cells (PBMC) isolated from Multiple Sclerosis (MS) patients

Miguel Tolentino, Chi C. Cho, Jeri‐Anne Lyons

Abstract Multiple sclerosis (MS) is an autoimmune disease characterized by myelin destruction, neurodegeneration and mitochondrial dysfunction. High production of nitric oxide (NO) by iNOS contributes to the generation of reactive nitrogen species, leading to increased nitrosative stress and mitochondrial dysfunction linked to …

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Characterization of the Effect of Photobiomodulation on Peripheral Blood Mononuclear Cells and Cd4+ T Cells from Healthy Donors and Multiple Sclerosis Subjects.

Miguel Tolentino

Multiple Sclerosis (MS) is a CD4+ T cell-mediated autoimmune demyelinating disease. The pathogenesis of MS is a combination of a pro-inflammatory autoimmune response coupled with nitrosative and oxidative stress. Mitochondrial dysfunction within the central nervous system (CNS) leads to a reduction of …

Photobiomodulation therapy (PBMT) regulates the production of IL-10 and IFN-Ɣ by peripheral blood mononuclear cells (PBMC) and CD4+ T cells isolated from subjects with Multiple Sclerosis (MS)

Miguel Tolentino, Chi C. Cho, Jeri‐Anne Lyons

Abstract Multiple sclerosis (MS) is a CD4+ Th1/Th17 mediated autoimmune disease characterized by myelin destruction, neurodegeneration and mitochondrial dysfunction. Current therapies suppress inflammation during early stages but are not effective in chronic stages characterized by oxidative damage. New therapies to slow progression, …

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