Marie‐Isabel Aguilar

The interactions between antimicrobial materials and bacterial membranes

Christopher Wilde, Tzong-Hsien Lee, Ketav Kulkarni, Jhih‐Hang Jiang et autres

Microbial contamination of surfaces in everyday use is an on-going challenge to prevent and eradicate. Furthermore, rapidly growing resistance of microorganisms to many drugs and disinfectants also poses a significant challenge in the design of more effective materials for managing such critical …

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Accurate quantitation of antibiotic penetration through staphylococcal biofilms

Lou Bin, David C. McGiffin, Thuy Thi Thu Nguyen, Wang Lv et autres

Objectives: Limited antimicrobial penetration is an important mechanism underlying antimicrobial resistance of biofilms and has often been incorrectly quantitated. We adopted a rationalized antibiotic agar-diffusion model to accurately interpret experimental results of a widely-accepted biofilm penetration assay, and to determine drug-related physiochemical …

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Gladiolin produced by pathogenic Burkholderia synergizes with amphotericin B through membrane lipid rearrangements

Claudia Simm, Tzong-Hsien Lee, Harshini Weerasinghe, Dean Walsh et autres

ABSTRACT Amphotericin B (AmpB) is an effective but toxic antifungal drug. Thus, improving its activity/toxicity relationship is of interest. AmpB disrupts fungal membranes by two proposed mechanisms: ergosterol sequestration from the membrane and pore formation. Whether these two mechanisms operate in conjunction …

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Targeting the Angiotensin AT2 Receptor to Treat Cardiac Fibrosis and Heart Failure

Yan Wang, Dorota Ferens, Ekaterina Salimova, Mark P. Del Borgo et autres

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Quest for New Generation Biocompatible Materials: Tailoring β-Peptide Structure and Interactions via Synergy of Experiments and Modelling

Marie‐Isabel Aguilar, Irene Yarovsky

Peptide-based self-assembly has been used to produce a wide range of nanostructures. While most of these systems involve self-assembly of α-peptides, more recently β-peptides have also been shown to undergo supramolecular self-assembly, and have been used to produce materials for applications in …

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Atomic Scale Structure of Self‐Assembled Lipidated Peptide Nanomaterials (Adv. Mater. 24/2024)

Billy J. Williams‐Noonan, Ketav Kulkarni, Nevena Todorova, Matteo Franceschi et autres

Self-Assembled Lipidated Peptide Nanomaterials β-Peptides have great potential as novel biomaterials and therapeutic agents due to their ability to self-assemble into low dimensional nanostructures resistant to degradation in vivo. Irene Yarovsky and co-workers develop a computational approach to model self-assembled β-peptide nanostructures …

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Atomic Scale Structure of Self‐Assembled Lipidated Peptide Nanomaterials

Billy J. Williams‐Noonan, Ketav Kulkarni, Nevena Todorova, Matteo Franceschi et autres

Abstract β‐Peptides have great potential as novel biomaterials and therapeutic agents, due to their unique ability to self‐assemble into low dimensional nanostructures, and their resistance to enzymatic degradation in vivo. However, the self‐assembly mechanisms of β‐peptides, which possess increased flexibility due to …

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The intricate link between membrane lipid structure and composition and membrane structural properties in bacterial membranes

Tzong-Hsien Lee, Patrick Charchar, Frances Separovic, Gavin E. Reid et autres

It is now evident that the cell manipulates lipid composition to regulate different processes such as membrane protein insertion, assembly and function. Moreover, changes in membrane structure and properties, lipid homeostasis during growth and differentiation with associated changes in cell size and …

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Decoding the role of mycobacterial lipid remodelling and membrane dynamics in antibiotic tolerance

Anjana P. Menon, Tzong-Hsien Lee, Marie‐Isabel Aguilar, Shobhna Kapoor

) infections, often neglecting the emerging issue of latent tuberculosis infection (LTBI) which are characterized by reduced susceptibility to antibiotics. The bacterium undergoes multiple adaptations during dormancy within host granulomas, leading to the development of antibiotic-tolerant strains. The mycobacterial membrane plays a …

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Professor Edouard Nice

John D. Wade, Marie‐Isabel Aguilar

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Novel AT2R agonist, β-Pro7Ang III, is cardio- and vaso-protective in diabetic spontaneously hypertensive rats

Mandy Li, Levi Nguyen, Dorota Ferens, Iresha Spizzo et autres

Stimulation of the angiotensin II type 2 receptor (AT2R) evokes protective effects in various cardiovascular diseases. Thus, this study aimed to investigate the effects of AT2R stimulation, with or without AT1R blockade, in a model of hypertension with concomitant type 1 diabetes …

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Differential membrane binding of a/ß-peptide foldamers: implications for cellular delivery and mitochondrial targeting

Tzong-Hsien Lee, James W. Checco, Tess R. Malcolm, Chelcie H. Eller et autres

The intrinsic pathway of apoptosis is regulated by the Bcl-2 family of proteins. Inhibition of the anti-apoptotic members represents a strategy to induce apoptotic cell death in cancer cells. We have measured the membrane binding properties of a series of peptides, including …

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