A. Yaël Nossent

The Dilution Paradox in Extracellular Vesicle Flow Cytometry

Joyce Rops, N Buntsma, Aleksandra Gąsecka, Leonie de Rond et autres

Concentrations of extracellular vesicles (EVs) can be measured by flow cytometry, which detects fluorescence and light scattering signals from single particles. To ensure single particle detection, plasma samples are diluted based on their particle concentration, which can differ 100-fold between samples. Here …

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Contributors

Panagiotis Alexiou, José Basílio, Daniel Benák, Erik A.L. Biessen et autres

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Epitranscriptomics and atherosclerosis

Daniel Benák, Markéta Hlaváčková, A. Yaël Nossent, Miron Sopić

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Biogenesis and mechanisms of action of ncRNAs

A. Yaël Nossent, Tijana Mitić, Andrea Caporali, Simona Greco et autres

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Role of ncRNAs in plaque development, progression, and stability

A. Yaël Nossent, Tijana Mitić, Nadja Sachs, Simona Greco et autres

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Validation of tRNA-derived fragments as diagnostic biomarkers in suspected acute stroke; limitations in analysis and quantification methods

Tamar Woudenberg, M. Leontien van der Bent, Daphne A. L. van den Homberg, Thuy Nguyen et autres

showed a trend for differential expression between stroke subtypes, but with insufficient predictive value to be of use in clinical practice. Combining expression data of specific tRFs into a joint model did not improve the predictive ability. Technical and computational challenges may …

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Epitranscriptomics in atherosclerosis: Unraveling RNA modifications, editing and splicing and their implications in vascular disease

Victoria Stopa, Dimitra Dafou, Korina Karagianni, A. Yaël Nossent et autres

Atherosclerosis remains a leading cause of morbidity and mortality worldwide, driven by complex molecular mechanisms involving gene regulation and post-transcriptional processes. Emerging evidence highlights the critical role of epitranscriptomics, the study of chemical modifications occurring on RNA molecules, in atherosclerosis development. Epitranscriptomics …

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Lipocalin 2 deficiency impacts angiogenesis after ischemia in vivo and in vitro

Zeen Aref, Erna Peters, Margreet R. de Vries, A. Yaël Nossent et autres

Therapeutic neovascularization is a promising therapy option for patients with peripheral arterial disease. We followed in time the gene expression after induction of hind limb ischemia in mice with different patterns of blood flow restoration and identified lipocalin 2 (LCN2) as a …

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Site‐specific m6A‐miR‐494‐3p, not unmethylated miR‐494‐3p, compromises blood brain barrier by targeting tight junction protein 1 in intracranial atherosclerosis

Tamar Woudenberg, M. Leontien van der Bent, Veerle Kremer, Ingeborg S. E. Waas et autres

BACKGROUND AND PURPOSE: Intracranial atherosclerosis is one of the most common causes of ischaemic stroke. However, there is a substantial knowledge gap on the development of intracranial atherosclerosis. Intracranial arteries are characterized by an upregulation of tight junctions between endothelial cells, which …

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Transfer RNAs are Linked to Ischemic Stroke and Major Bleeding in Patients with End-Stage Kidney Disease

Stephan Nopp, Oliver Königsbrügge, Sabine Schmaldienst, Marcus D. Säemann et autres

BACKGROUND: Patients with end-stage kidney disease (ESKD) are at very high risk for thromboembolism and bleeding. This study aimed to identify small noncoding RNAs (sncRNAs), specifically microRNAs and transfer-RNA (tRNA)-derived fragments (tRFs), as potential novel biomarkers for predicting thromboembolism and bleeding in …

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Circular RNA regulatory role in pathological cardiac remodelling

Alessia Bibi, Monika Barteková, Shrey Gandhi, Simona Greco et autres

Cardiac remodelling involves structural, cellular and molecular alterations in the heart after injury, resulting in progressive loss of heart function and ultimately leading to heart failure. Circular RNAs (circRNAs) are a recently rediscovered class of non-coding RNAs that play regulatory roles in …

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Transfer RNAs, not microRNAs, are linked to ischemic stroke and major bleeding in patients with end-stage kidney disease – a nested case-control study from the VIVALDI cohort

Stephan Nopp, Oliver Königsbrügge, Marcus D. Säemann, Ingrid Pabinger et autres

Introduction Patients with end-stage kidney disease (ESKD) are at particularly high risk for thromboembolism and bleeding. This study aimed to identify small non-coding RNAs (sncRNAs), specifically microRNAs and transfer RNA (tRNA)-derived fragments (tRFs), as potential novel biomarkers for thromboembolism and bleeding in …

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