Majd A. AbuAlrob

GLP-1 Receptor Agonists and Neurological Outcomes in Multiple Sclerosis: A TriNetX Retrospective Cohort Study

Majd A. AbuAlrob, Khaled Zammar, BEATRIZ CANIBANO, Dirk Deleu

Age-dependent differences in treatment patterns and clinical outcomes in multiple sclerosis: a propensity-matched TriNetX analysis

Adham Itbaisha, Yahya Kayed Abujwaid, Majd A. AbuAlrob, Khaled Zammar et autres

Real-World Safety of Anti-CD20 vs Oral DMTs in MS: A Target Trial Emulation Using the TriNetX Network

Majd A. AbuAlrob, Khaled Zammar, BEATRIZ CANIBANO, Abdullah Hussein

Standard Antiplatelet Therapy Versus Thrombolysis in Acute Spontaneous Spinal Cord Infarction: A Propensity Score–Matched Analysis

Majd A. AbuAlrob, Ali Al‐Salahat, Khaled Zammar, Salman Al Jerdi

BACKGROUND: Spinal cord infarction (SCI) is a rare stroke subtype with no established acute treatment guidelines. Thrombolytic therapy has been used empirically based on extrapolation from cerebral stroke protocols, but comparative effectiveness data are lacking. We compared outcomes between standard care and …

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The gut microbiome and drug‐resistant epilepsy: Microbiome–antiseizure medication interactions and implications for pharmacoresistance

Khaled Zammar, Majd A. AbuAlrob, Musab Ali, Simona Lattanzi et autres

Drug-resistant epilepsy (DRE) affects approximately one-third of patients with epilepsy and represents a major unmet clinical need. While traditional hypotheses of pharmacoresistance have focused on alterations in drug targets, efflux transporter overexpression, and intrinsic disease severity, the gut microbiome has recently emerged …

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Incidence and prevalence of multiple sclerosis in Qatar: A population-based study from 2016 to 2024

Majd A. AbuAlrob, Rola Khodair, Faiza Ibrahim, Shahd Hamid et autres

BACKGROUND: Epidemiological data on multiple sclerosis (MS) in the Arabian Gulf remain limited. This study determined the incidence and minimum prevalence of MS in Qatar over a nine-year period. METHODS: This retrospective, population-based study identified incident MS cases from January 2016 through …

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Fracture Risk With Lacosamide vs Levetiracetam Monotherapy in Adults With Epilepsy

Majd A. AbuAlrob, Ali Al‐Salahat, Rand Abdellatif, Khaled Zammar et autres

OBJECTIVES: Patients with epilepsy exhibit substantially elevated fracture risk. However, comparative skeletal safety data for newer antiseizure medications (ASMs) remain limited. The aim of this study was to compare fracture risk between lacosamide and levetiracetam monotherapy in adults with epilepsy. METHODS: This …

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Optic Atrophy (OA) in Autoimmune Encephalitis (AE) and Risk of Subsequent Cognitive Impairment: A Propensity-matched Cohort Study (P9-1.011)

Waleed Alon, Majd A. AbuAlrob, Khaled Zammar, BEATRIZ CANIBANO et autres

To determine whether AE patients with OA have an increased risk of Cognitive Impairment compared with Isolated AE patients.

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Early-onset Alzheimer's disease mortality in the United States: A population-based study of trends and disparities, 2015–2024

Ali Al‐Salahat, Ali Bin Abdul Jabbar, Keara Kennedy, Andy Song et autres

BackgroundPopulation-level data on trends and disparities in early-onset Alzheimer's disease (EOAD) mortality are limited.ObjectiveThis study aimed to examine demographic disparities and trends in mortality from EOAD in the US from 2015 to 2024.MethodsWe analyzed US mortality data from the Centers for Disease …

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Monoclonal antibody efficacy in seropositive vs seronegative NMOSD: systematic review and meta-analysis

Khaled Zammar, Abeer Safan, Dareen Jamal Abushalbak, Adam Daromar et autres

Background and objectives Monoclonal antibodies have transformed the treatment of neuromyelitis optica spectrum disorder (NMOSD), yet their comparative efficacy by aquaporin-4 immunoglobulin G (AQP4-IgG) serostatus remains uncertain. We conducted a systematic review and meta-analysis to compare monoclonal antibody efficacy between AQP4-IgG seropositive …

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Novel epilepsy treatments in clinical development

Boulenouar Mesraoua, Bassel Abou-Khalil, Simona Lattanzi, Ali A. Asadi-Pooya et autres

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Disrupting the Frontal Aslant Tract: Network Evidence for Speech Initiation Deficits in a Non-Anglophone Stroke Survivor

Majd A. AbuAlrob, Khaled Zammar, Fatima Mallat, Nadin Abuozied et autres

BACKGROUND: The frontal aslant tract (FAT) is a direct cortico-cortical intra-frontal pathway linking the inferior frontal gyrus with the pre-supplementary and supplementary motor areas and is implicated in speech initiation and verbal fluency. However, much of the available evidence regarding its role …

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