Nivedha Kannapadi

A Multi-AI Agent Framework for Interactive Neurosurgical Education and Evaluation: From Vignettes to Virtual Conversations

Karl L. Sangwon, Jeff Zhang, Robert Steele, Jaden Stryker et autres

BACKGROUND AND OBJECTIVES: Traditional medical board examinations present clinical information in static vignettes with multiple-choices (MC), fundamentally different from how physicians gather and integrate data in practice. Recent advances in large language models (LLMs) offer promising approaches to creating more realistic clinical …

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A Multi-AI Agent Framework for Interactive Neurosurgical Education and Evaluation: From Vignettes to Virtual Conversations

Karl L. Sangwon, Jeff Zhang, Robert Steele, Jaden Stryker et autres

ABSTRACT Background and Objectives Traditional medical board examinations present clinical information in static vignettes with multiple-choices, fundamentally different from how physicians gather and integrate data in practice. Recent advances in Large Language Models (LLMs) offer promising approaches to creating more realistic clinical …

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Outcomes of Radiosurgery for WHO Grade 2 Meningiomas: The Role of Ki-67 Index in Guiding the Tumor Margin Dose

Ying Meng, Kenneth E. Bernstein, Elad Mashiach, Brandon Santhumayor et autres

BACKGROUND AND OBJECTIVES: The management of World Health Organization (WHO) grade 2 meningiomas is complicated by their diverse clinical behaviors. Stereotactic radiosurgery (SRS) can be an effective management option. Literature on SRS dose selection is limited but suggests that a higher dose …

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RBIO-04. OUTCOMES OF RADIOSURGERY FOR WHO GRADE 2 MENINGIOMAS: THE ROLE OF KI-67 INDEX IN GUIDING THE TUMOR MARGIN DOSE

Ying Meng, Kenneth E. Bernstein, Elad Mashiach, Brandon Santhumayor et autres

Abstract The management of WHO grade 2 meningiomas is complicated by their diverse clinical behaviors. Stereotactic radiosurgery (SRS) can be an effective management option. Literature on SRS dose selection is limited, but suggests a higher dose is better for tumor control. We …

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CCR2 and CCR5 co-inhibition modulates immunosuppressive myeloid milieu in glioma and synergizes with anti-PD-1 therapy

Ayush Pant, Brandon Hwa-Lin Bergsneider, Siddhartha Srivastava, Timothy Kim et autres

Immunotherapy has revolutionized the treatment of cancers. Reinvigorating lymphocytes with checkpoint blockade has become a cornerstone of immunotherapy for multiple tumor types, but the treatment of glioblastoma has not yet shown clinical efficacy. A major hurdle to treat GBM with checkpoint blockade …

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159 PD-1 Agonism as a Strategy to Prevent Neuroinflammation After Acute Large Vessel Occlusion

Jennifer E. Kim, Ryan P. Lee, Eli Yazigi, James Feghali et autres

INTRODUCTION: Stroke is a leading cause of death and long-term disability worldwide. Acute ischemia results in a profound inflammatory response that is counterproductive to short- and long-term recovery. Programmed Death Protein 1 (PD-1) is an immune checkpoint that has been shown to …

Neuropathological findings in COVID-19 vs. non-COVID-19 acute respiratory distress syndrome—A case-control study

Mariyam Humayun, Lucy Zhang, Thomas D. Zaikos, Nivedha Kannapadi et autres

Acute brain injury (ABI) and neuroinflammation is reported in COVID-19 and acute respiratory distress syndrome (ARDS). It remains unclear if COVID-19 plays an independent role in development of ABI compared to those with non-COVID-19 ARDS. We aimed to evaluate if COVID-19 ARDS …

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Soluble PD-L1 reprograms blood monocytes to prevent cerebral edema and facilitate recovery after ischemic stroke

Jennifer E. Kim, Ryan P. Lee, Eli Yazigi, Lyla Atta et autres

Acute cerebral ischemia triggers a profound inflammatory response. While macrophages polarized to an M2-like phenotype clear debris and facilitate tissue repair, aberrant or prolonged macrophage activation is counterproductive to recovery. The inhibitory immune checkpoint Programmed Cell Death Protein 1 (PD-1) is upregulated …

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Neuropathological Findings in COVID-19 vs non-COVID-19 Acute Respiratory Distress Syndrome - A Case-Control Study

Mariyam Humayun, Lucy Zhang, Thomas D. Zaikos, Nivedha Kannapadi et autres

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Neuropathological Findings in COVID-19 Vs Non-COVID-19 Acute Respiratory Distress Syndrome - a Matched Case Control Study

Mark S. Humayun, L. Zhang, Thomas D. Zaikos, Nivedha Kannapadi et autres

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772 Re-examining the Role of Post-Operative ICU Admission for Patients Undergoing Elective Craniotomy: A Systematic Review

Tej D. Azad, Pavan P. Shah, Nivedha Kannapadi, Jordina N. Rincon Torroella et autres

INTRODUCTION: The standard-of-care for post-operative care following elective craniotomy has historically been intensive care unit (ICU) admission. However, recent literature interrogating complications and interventions during this post-operative ICU stay suggests that all patients may not require this level of care. Thus, hospitals …

Management of Anticoagulation Therapy in ECMO-Associated Ischemic Stroke and Intracranial Hemorrhage

Rochelle Prokupets, Nivedha Kannapadi, Henry Chang, Giorgio Caturegli et autres

OBJECTIVE: Despite the common occurrence of extracorporeal membrane oxygenation (ECMO)-associated acute ischemic stroke (AIS) and intracranial hemorrhage (ICH), there are little data to guide optimal anticoagulation management. We sought to describe antithrombotic therapy management after stroke and outcomes. METHODS: A retrospective analysis …

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