Ewan Gray

Implementing a Risk-Stratified National Breast Screening Programme in the United Kingdom: A Model-Based Cost-effectiveness Analysis

Stuart James Wright, Joe Hilton, G Rogers, Ewan Gray et autres

BACKGROUND: Risk-stratified breast screening, where women are offered different screening intervals based on their breast cancer risk, has been proposed as a way to improve the benefits of screening in the United Kingdom National Breast Screening Programme (UK-NBSP). The aim of this …

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1740P Early detection of pancreatic cancer with a multi-omic liquid biopsy

James Malcolm Cameron, Harry J. Butler, Matthew J. Baker, D.A. Palmer et autres

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Does earlier diagnosis and treatment of brain tumours matter? Time-to-treatment intervals and tumour size at detection; impact on survival, recurrence, inpatient length of stay and neurological deficit

Ewan Gray, James Malcolm Cameron, A.W. Lishman, Peter S Hall et autres

Abstract Background The importance of timely diagnosis of brain tumours is well recognised but how this translates to impacts on important patient outcomes is not well described. This study aimed to quantify the effect of time-to-treatment interval and tumour size at diagnosis …

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Earlier brain tumor detection: Assessing the impact on survival, recurrence, inpatient length of stay and neurological deficit.

Holly J. Butler, Ewan Gray, James Munro Cameron, Paul Brennan et autres

e23268 Background: Brain tumors commonly present in an emergency setting, but the majority of patients diagnosed with a brain tumor will have had one or more primary care visits in the preceding months. This suggests opportunities for earlier diagnosis. Early economic evaluation …

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Abstract 5965: Brain tumor diagnostic interval and tumor size at detection: Impact on survival, recurrence, inpatient length of stay and neurological deficit

James Malcolm Cameron, Ewan Gray, Paul Brennan, Matthew Baker et autres

Abstract Brain tumors commonly present in an emergency setting. However, the majority of brain tumor patients report one or more primary care visits in the preceding months. This suggests opportunities for earlier diagnosis. Early economic evaluation of a brain cancer liquid biopsy …

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EE719 Impact of Stage at Cancer Diagnosis on Total Healthcare Costs: A National Population-Based Study Using England Individual-Level Patient Data

D.R. Jones, Guy G. Baily, Robert Allen Cherry, Sara Hiom et autres

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A structured process for the validation of a decision-analytic model: application to a cost-effectiveness model for risk-stratified national breast screening

Stuart James Wright, Ewan Gray, G Rogers, Anna Donten et autres

BACKGROUND: Decision-makers require knowledge of the strengths and weaknesses of decision-analytic models used to evaluate healthcare interventions to be able to confidently use the results of such models to inform policy. A number of aspects of model validity have previously been described, …

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Evaluation of a Risk-Stratified National Breast Screening Programme in the United Kingdom: An updated cost-effectiveness analysis

Stuart James Wright, G Rogers, Ewan Gray, Anna Donten et autres

Abstract Study objective To update a published early economic evaluation of exemplar risk-stratified national breast screening programmes (stratified-NBSP). Method An existing validated decision-analytic model, using discrete event simulation (the ‘Gray-model’), was used to structure the pathways for 3 stratified-NBSP (risk-1; risk-2; risk-3) …

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Trade-offs between overall survival and side effects in the treatment of metastatic breast cancer: eliciting preferences of patients with primary and metastatic breast cancer using a discrete choice experiment

Alistair Bullen, Mandy Ryan, Holly Ennis, Ewan Gray et autres

OBJECTIVES: There has been a recent proliferation in treatment options for patients with metastatic breast cancer. Such treatments often involve trade-offs between overall survival and side effects. Our study aims to estimate the trade-offs that could be used to inform decision-making at …

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EP12.01-60 An Observational Study Analyzing Progression Free Survival of Patients With EGFR Mutant NSCLC Treated with Osimertinib in South Carolina

Michael D. Pavy, Ronald Cassada, M. Davidson, Ewan Gray

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Variation in hospital cost trajectories at the end of life by age, multimorbidity and cancer type

Katharina Diernberger, Xhyljeta Luta, Joanna Bowden, Joanne Droney et autres

Background: Approximately thirty thousand people in Scotland are diagnosed with cancer annually, of whom a third live less than one year. The timing, nature and value of hospital-based healthcare for patients with advanced cancer are not well understood. The study's aim was …

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Validation of a decision-analytic model for the cost-effectiveness analysis of a risk-stratified National Breast Screening Programme in the United Kingdom

Stuart James Wright, Ewan Gray, G Rogers, Anna Donten et autres

Abstract Background This study follows structured frameworks to assess the internal and external validity of a decision-analytic model-based cost-effectiveness of approaches to implement a risk-stratified national breast screening programme (risk-NBSP) in the United Kingdom (UK). Methods A pre-defined set of steps were …

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