M. Schumacher

Effects of ovarian ablation or suppression on breast cancer recurrence and survival: patient-level meta-analysis of 15 000 women in 23 randomised trials

Rosie Bradley, Jeremy Braybrooke, Mike Clarke, Robert K. Hills et autres

BACKGROUND: For premenopausal women with oestrogen receptor (ER)-positive early breast cancer, the additional protective effect of ovarian function suppression (OFS, by ablation or drugs) may depend on menopausal status after any chemotherapy, and tamoxifen usage. We assess the effects of OFS on …

Ruxolitinib versus allogeneic stem cell transplantation for patients with myelofibrosis according to donor availability: A prospective multicenter phase II trial

Nico Gagelmann, Christine Wolschke, Tobias A.W. Holderried, Eva Eßeling et autres

Abstract Introduction: Myelofibrosis is a chronic myeloproliferative neoplasm characterized by bone marrow fibrosis, splenomegaly, and debilitating constitutional symptoms, often resulting in significant morbidity and mortality. Allogeneic hematopoietic stem-cell transplantation (SCT) remains the only potentially curative treatment but is associated with considerable risks. …

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Schizophrenia and schizoaffective are useful terms of essential concepts in medicine: what we need is a general consideration and more research regarding the causes of secondary psychotic syndromes

João Gama Marques, M. Schumacher, Josef Finsterer

pt (code pays fourni par la source)

Hazards Constitute Key Quantities for Analyzing, Interpreting and Understanding Time‐to‐Event Data

Jan Beyersmann, Claudia Schmoor, M. Schumacher

Censoring makes time-to-event data special and requires customized statistical techniques. Survival and event history analysis therefore builds on hazards as the identifiable quantities in the presence of rather general censoring schemes. The reason is that hazards are conditional quantities, given previous survival, …

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Sequential Dosing of Next-Generation IMA203CD8 TCR-T-Cell Therapy Targeting PRAME in Combination with BRAF-/MEK-Inhibition in a Melanoma Patient with Progressive Disease - a Case Report

Friederike Schmitz, M. Schumacher, Annkristin Heine, Annette Busch et autres

Background: T-cell-receptor (TCR)- T-cell therapies have shown promising results in cancer patients, most notably to date in patients with advanced melanoma. However, there is little data on delayed sequential dosing of TCR-T-cell therapies in patients with progressive disease. Split-dosing of TCR or …

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392 A case series of IMA203 TCR-T-cell therapy targeting PRAME in combination with BRAF-/MEK-inhibition in two melanoma patients with active CNS metastases

Friederike Schmitz, Katharina Epp, M. Schumacher, Annkristin Heine et autres

Background Adoptive cell therapy with T-cell receptor-modified T-cells (TCR-T) is emerging as an attractive therapeutic approach in patients with solid tumors. Recently, we have shown promising results of IMA203, a TCR-T product targeting the cancer testis antigen PRAME in heavily pretreated melanoma …

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Conditional survival of younger patients with mantle cell lymphoma: Results from a randomized phase III trial of the European MCL Network

Linmiao Jiang, Martin Dreyling, Olivier Hermine, Ulrich Mansmann et autres

During a fatal disease, patients often request updated information on their prognosis. After patients have already survived a certain time, conditional survival captures their future survival probability. We investigated conditional overall and failure-free survival in 473 younger mantle cell lymphoma (MCL) patients …

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Immunological Effectiveness of Carbon Ion Radiotherapy in Pancreatic Cancer

Brett I. Bell, Shivam Pandey, Beata Małachowska, M. Schumacher et autres

Antibiotic Prophylaxis During Allogeneic Stem Cell transplantation—A Comprehensive Single Center Retrospective Analysis

Charlotte Neuerburg, Friederike Schmitz, Marie‐Therese Schmitz, Susanne Rehnelt et autres

• Antibiotic prophylaxis during allogeneic stem cell transplantation (allo-HSCT) is still controversial due to the potential increase in Graft- versus -Host Disease (GvHD) development and drug related toxicities with antibiotic prophylaxis versus a potentially higher risk of severe infections without. • Analyses …

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Editorial: Mental illness and neuropsychiatry of the homeless: psychosis, personality, drug abuse, and other brain disorders

João Gama Marques, Joana Henriques‐Calado, M. Schumacher

Editorial: Mental illness and neuropsychiatry of the homeless: psychosis, personality, drug abuse, and other brain disorders

pt (code pays fourni par la source)

Model-independent search for the presence of new physics in events including H → γγ with $$ \sqrt{s} $$ = 13 TeV pp data recorded by the ATLAS detector at the LHC

G. Aad, B. Abbott, K. Abeling, S. H. Abidi et autres

Abstract A model-independent search for new physics leading to final states containing a Higgs boson, with a mass of 125.09 GeV, decaying to a pair of photons is performed with 139 fb−1of $$ \sqrt{s} $$ s = 13 TeVppcollision data recorded by …

fr, us, de, Maroc, il, cl, it, pl, ca, tr, ch, gb, es, ro, az, se, gr, ar, br, pt, no, jp (code pays fourni par la source)

Search for boosted diphoton resonances in the 10 to 70 GeV mass range using 138 fb−1 of 13 TeV pp collisions with the ATLAS detector

G. Aad, B. Abbott, D. C. Abbott, K. Abeling et autres

A bstract A search for diphoton resonances in the mass range between 10 and 70 GeV with the ATLAS experiment at the Large Hadron Collider (LHC) is presented. The analysis is based on pp collision data corresponding to an integrated luminosity of …

fr, us, de, Maroc, il, cl, gb, it, pl, ca, tr, ch, es, ro, az, se, ar, cz, gr, nl, tw, br, pt, no, jp (code pays fourni par la source)