Diany Paola Calderon

Neurophysiological correlates of delayed recovery of consciousness in a critically ill patient with COVID-19 with repeated cardiac arrest

Seyed A. Safavynia, Akshay Shanker, Jessica Wang, J. Choi et autres

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Perioperative neurocognitive disorders: the importance of global systemic interactions

Diany Paola Calderon, Hugh C. Hemmings

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Current and Developing Approaches for Facilitating Emergence from General Anesthesia

Kathleen F. Vincent, Dinesh Pal, Zheng Xie, Aaron P. Fox et autres

Despite the widespread use of clinical anesthesia, the process of emergence from general anesthesia remains primarily driven by anesthetic elimination. Although emergence from general anesthesia is typically safe, prolonged delays strain resource-intensive settings and contribute to increased healthcare costs. In addition to …

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Cortical signatures linked to behavior quantitatively track arousal levels

Sijia Gao, Yelena Bibineyshvili, Seyed A. Safavynia, Juan Calderón-Martínez et autres

While current arousal level assessments in patients with disorders of consciousness discriminate altered states of consciousness, there are significant limitations in characterizing the transition from one state to another or quantifying the frequent arousal level fluctuations observed in a patient. Here, we …

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Overactive Glutamatergic Basal Forebrain: Compensatory or Causal Mechanism in Cognitive Disorders

Diany Paola Calderon, Peter A. Goldstein

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Elevated Plasma Complement C1Q Measured Subacutely after Traumatic Brain Injury Is Associated with Poor Functional Outcome Independent of Initial Injury Severity

Tracy Butler, Kewei Chen, Abigail Patchell, Xiangling Mao et autres

Following traumatic brain injury (TBI), secondary processes, including inflammation, contribute significantly to long-term cognitive and functional impairments. Targeting these secondary processes during the subacute period after TBI represents a feasible therapeutic target. This study investigates the role of complement factor 1q (C1Q) …

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Secondary-blast injury in rodents produces cognitive sequelae and distinct motor recovery trajectories

Jasmine Gamboa, J. Horváth, Amanda A. Simon, Md. Safiqul Islam et autres

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Objective and graded calibration of recovery of consciousness in experimental models

Diany Paola Calderon, Nicholas D. Schiff

PURPOSE OF REVIEW: Experimental preclinical models of recovery of consciousness (ROC) and anesthesia emergence are crucial for understanding the neuronal circuits restoring arousal during coma emergence. Such models can also potentially help to better understand how events during coma emergence facilitate or …

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Continuous regimens of cortico-motor integration calibrate levels of arousal during emergence from anesthesia

Sijia Gao, Diany Paola Calderon

Abstract Background Recovery to a conscious state when emerging from anesthesia requires full cortical desynchronization, initiation of movement and behavioral reactivity to sensory stimuli. However, the variety of cortical electroencephalogram (EEG) patterns associated with specific anesthetics and the paucity of behavioral descriptions …

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Activating an anterior nucleus gigantocellularis subpopulation triggers emergence from pharmacologically-induced coma in rodents

Sijia Gao, Alex Proekt, Nicolas Renier, Diany Paola Calderon et autres

Multiple areas within the reticular activating system (RAS) can hasten awakening from sleep or light planes of anesthesia. However, stimulation in individual sites has shown limited recovery from deep global suppression of brain activity, such as coma. Here we identify a subset …

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Generalized CNS arousal: An elementary force within the vertebrate nervous system

Diany Paola Calderon, Amos Maritan, Jayanth R. Banavar, Donald W. Pfaff

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Development of Electrophysiological Properties of Nucleus Gigantocellularis Neurons Correlated with Increased CNS Arousal

Xu Liu, Donald W. Pfaff, Diany Paola Calderon, Inna Tabansky et autres

Many types of data have suggested that neurons in the nucleus gigantocellularis (NGC) in the medullary reticular formation are critically important for CNS arousal and behavioral responsiveness. To extend this topic to a developmental framework, whole-cell patch-recorded characteristics of NGC neurons in …

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