Tie-Qiang Liu

[Embryonic Stem Cell-Derived Mesenchymal Stromal Cell Exosomes Protect Against Radiation-Induced Lymphocyte Injury and Its Related Mechanisms].

Jia-Xin Chen, Zhi-Qing Liu, Yang-Yang Lei, Dong-Mei Wang et autres

OBJECTIVE: To explore the repair effect and its related mechanism of exosomes derived from embryonic stem cell-induced mesenchymal stromal cells (ESC-MSC) on radiation-induced lymphocyte damage. METHODS: Co γ-rays, then they were co-cultured with ESC-MSC-Exo or BM MSC-Exo for 48 hours. Apoptosis, DNA …

cn (code pays fourni par la source)

A single-cell panorama of human umbilical cord blood-derived expanded memory-like natural killer cells

Yi Wang, Bo Cai, Yangyang Lei, Dan Mo et autres

cn (code pays fourni par la source)

[The Role of NK Cells in Allogeneic Hematopoietic Stem Cell Micro-Transplantation for Acute Myeloid leukemia].

Ruyu Liu, Chang‐Lin Yu, Jian‐Hui Qiao, Bo Cai et autres

OBJECTIVE: To explore the role of NK cells in allogeneic hematopoietic stem cell micro-transplantation(MST) in the treatment of patients with acute myeloid leukemia(AML). METHODS: Data from 93 AML patients treated with MST at our center from 2013-2018 were retrospectively analyzed. The induction …

cn (code pays fourni par la source)

[Efficacy and Prognostic Factors of Nonmyeloablative Allogeneic Hematopoietic Stem Cell Transplantation for Patients with Acute Myeloid Leukemia].

Yan‐Ping Shi, Bo Cai, Chang-Lin Yu, Jian‐Hui Qiao et autres

OBJECTIVE: To retrospectively analyze the efficacy and complications of our institution's modified nonmyeloablative allogeneic hematopoietic stem cell transplantation (NST) in treating intermediate-risk acute myeloid leukemia (AML) - first complete remission (CR1) and prognostic factors. METHODS: Clinical data of 50 intermediate-risk AML-CR1 patients …

cn (code pays fourni par la source)

Mismatched donor cell infusion-related syndrome following microtransplant in patients with acute myeloid leukemia

Bo Cai, Xiaoyan Zou, Xin Ning, Tie-Qiang Liu et autres

BACKGROUND: Immunotherapies such as adoptive immune cell infusion and immune-modulating agents are widely used for cancer treatment, and the concomitant symptoms, including cytokine release syndrome (CRS) or immune-related adverse events (irAEs), are frequently reported. However, clinical manifestations induced by mismatched donor granulocyte …

il, cn (code pays fourni par la source)

Hyper-CVAD-Based Stem Cell Microtransplant as Post-Remission Therapy in Acute Lymphoblastic Leukemia

Bo Cai, Yi Wang, Yangyang Lei, Yan‐Ping Shi et autres

Post-remission strategies for patients with acute lymphoblastic leukemia (ALL) are limited to the multiagent chemotherapy and allogeneic stem cell transplant (allo-SCT), and cellular therapies are seldom involved. Although chemotherapy combined with mismatched granulocyte colony-stimulating factor mobilized peripheral blood mononuclear cell infusion (microtransplant, …

cn (code pays fourni par la source)

[Immunophenotypic Features and Clinical Prognosis of Patients with Mixed Phenotype Acute Leukemia].

Tie-Qiang Liu, Xinyang Li, Bing-Xia Li, Bo Yao et autres

OBJECTIVE: To retrospectively analyze the laborotary test results and clinical data of 31 patients with mixed phenotype acute leukemia (MPAL) in order to summarize and discuss the biological characteristics, curative effect, and prognosis of each subtype of MPAL based on immunophenotype results. …

cn (code pays fourni par la source)

Co-infusion of high-dose haploidentical donor cells and CD19-targeted CART cells achieves complete remission, successful donor engraftment and significant CART amplification in advanced ALL

Chang-Lin Yu, Bo Cai, Yao Wang, Zhiqiang Wu et autres

Autologous CD19-targeted chimeric antigen receptor-modified T cells (CD19-CART) remarkably improved the outcome of patients with advanced B-cell acute lymphoblastic leukemia (B-ALL). However, the application and outcomes of allogeneic CART cells is still uncertain. Two patients with advanced B-ALL were enrolled to receive …

cn (code pays fourni par la source)

Comparison of microtransplantation, chemotherapy and allogeneic transplantation in post-remission therapy for Philadelphia chromosome-positive acute lymphoblastic leukemia.

Bo Cai, Qi‐Yun Sun, Jian‐Hui Qiao, Chang-Lin Yu et autres

ALL.

cn (code pays fourni par la source)

HLA-Mismatched Microtransplant in Older Patients Newly Diagnosed With Acute Myeloid Leukemia

Mei Guo, Nelson Jen An Chao, Jianyong Li, David Alan Rizzieri et autres

IMPORTANCE: The outcome of older patients with acute myeloid leukemia (AML) remains unsatisfactory. Recent studies have shown that HLA-mismatched microtransplant could improve outcomes in such patients. OBJECTIVE: To evaluate outcomes in different age groups among older patients with newly diagnosed AML who …

cn, us, es (code pays fourni par la source)

[Biological characteristics of Microvesicles Derived from Bone Marrow Mesenchymal Stem Cells and Their Capacities Supporting ex vivo Expansion of Hematopoietic Stem Cells].

Yumeng Liang, Xiaona Wang, Lei Deng, Lu Wang et autres

OBJECTIVE: To explore the biological characteristics of microvesicles(MV) derived from bone marrow mesenchymal stem cells (BM-MSC) and their capability supporting ex vivo expansion of hematopoietic stem cells(HSC). METHODS: The MV from cultured BM-MSC supernatant were isolated by multi-step differential velocity contrifugation; the …

cn (code pays fourni par la source)

[Effect of Infusion of Recipient Spleen Cells at Different Time after Murine Haploidentical Hematopoietic Stem Cell Transplantation on Graft Versus Host Disease].

Junhui Wang, Lei Deng, Lu Wang, Liang Chen et autres

OBJECTIVE: To explore the effect of infusing G-CSF mobilized recipient spleen cells at different time after haploidentical stem cell transplantation(HSCT) on graft-versus-host disease (GVHD) in mice and its possible mechanism. METHODS: cell subsets and FasL in peripheral blood were detected by flow …

cn (code pays fourni par la source)