Milena Villarroel

Blood Gene Expression Profiles for Early Identification of Sepsis in Children with Cancer and Episodes of Fever and Neutropenia

Sandra Castejon‐Ramirez, Juan Pablo Torres, Zhaohui Xu, Verónica de la Maza et autres

Abstract Background Invasive bacterial infections are a leading cause of mortality in children with cancer and febrile neutropenia (FN). Clinical tools have been developed to predict sepsis in this population but the added value of comprehensive biomarkers such as RNA expression profiling …

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Molecular diagnostics in paediatric oncology in Latin America: findings from the Latin America Regional Advisory Committee (RAC LATAM) regional assessment

Julia Palma, Sofía Alijaro, Daniela Acre, Milena Villarroel et autres

Molecular diagnostics are an essential component of paediatric oncology care, providing critical information for disease classification, risk stratification and the selection of targeted therapies, ultimately improving patient outcomes. This study presents the results of the 2024 Latin America Regional Advisory Committee and …

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A Model-Informed Early Prediction of Methotrexate-Induced Acute Kidney Injury in Pediatric Patients with Osteosarcoma Using Real-World Data: A Multi-center Pharmacokinetic Study

Patricia Rega, Jorge Morales Vallespin, Azucena Aldaz, Andrew Pappas et autres

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Regional Landscape of Access, Availability, and Quality of Essential Pediatric Oncology Medicines in Latin America: Results From a Multicountry Survey

Liliana Vásquez, Edith Grynszpancholc, Diana Valencia, Milena Villarroel et autres

ABSTRACT Background Equitable access to essential pediatric oncology medicines is critical for improving childhood cancer outcomes in Latin America. However, disparities in availability, affordability, and quality continue to threaten treatment continuity and survival. This study assessed access to essential pediatric oncology medicines …

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Challenges in Launching a Precision Pediatric Oncology Program in Argentina

María Mercedes Paladino, Nicolás A. Pinto, David Verón, Fabiana Morosini et autres

BACKGROUND/OBJECTIVES: Advances in pediatric cancer care have underscored the importance of tumor sequencing for diagnosis and treatment selection. However, access to genomic diagnostics in Latin America remains limited. The COPPA Project, an initiative based in Argentina, was conceived to assess the feasibility …

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Clinical Trials for Children and Adolescents With Cancer in Latin America

Catrian Sotelo, Margit K. Mikkelsen, Oscar González‐Ramella, Milena Villarroel et autres

The improvement of childhood cancer outcomes has relied on clinical trials. The WHO's International Clinical Trials Registry Platform was searched for interventional clinical trials for children and adolescents with cancer in Latin America. Forty-seven trials were identified. Institutions were the primary sponsors …

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Latin American Consensus on the Use of Anti-GD2 Monoclonal Antibody Therapy in Patients With High-Risk Neuroblastoma

Gabriela I. Villanueva, Sandra Alarcón, Diana Bonilla, Alejandra Casanovas et autres

PURPOSE: To develop a Latin American expert consensus to support, guide, and accelerate the approval and equitable access to anti-GD2 immunotherapy for patients with high-risk neuroblastoma (HR-NB) in the region. Survival rates for HR-NB have improved with the incorporation of anti-GD2 immunotherapy; …

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Pathologic and Molecular Diagnosis of Ewing Sarcoma: A Multicenter Analysis From the Latin American Cooperative Group Trial

Andre Tesainer Brunetto, Lauro José Gregianin, Marialva Sinigaglia, Julie Francine Cerutti Santos Pestilho et autres

INTRODUCTION: Ewing Sarcoma (ES) is a small, round, blue cell tumor (SRBCT) characterized by a chromosomal translocation between chromosomes 11 and 22 in ~85% of cases, alongside immunohistochemical (IHC) expression of the surface glycoprotein CD99. Despite advancements in molecular diagnostics, low-income countries …

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Results of the Latin American Pediatric Oncology Group (GALOP) Trial for Patients With Metastatic Ewing Sarcoma: Multicentric Study of Interval‐Compressed Multiagent and Metronomic Chemotherapy

Adriana Rosé, Lauro José Gregianin, Érica Boldrini, Carla Renata Donato Macedo et autres

BACKGROUND: GALOP investigators developed a multicenter protocol to standardize treatment for newly diagnosed metastatic Ewing sarcoma (ES) in South America. METHODS: Prospective trial. Induction chemotherapy consisted of 9 alternating interval-compressed cycles (every 14 days) of vincristine, doxorubicin, cyclophosphamide, and ifosfamide-etoposide; local and …

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Results of the Latin American Pediatric Oncology Group (GALOP‐2011) Trial for Patients With Localized Ewing Sarcoma: A Multicentric Study of Interval‐Compressed Multiagent Chemotherapy

Lauro José Gregianin, Adriana Rosé, Milena Villarroel, Maria Tereza Assis de Almeida et autres

BACKGROUND: GALOP investigators developed a prospective cooperative protocol for localized Ewing sarcoma (ES) incorporating interval-compressed chemotherapy (VDC/IE, vincristine, doxorubicin, cyclophosphamide/ifosfamide and etoposide). After completing conventional treatment, patients were randomized to 1 year of metronomic chemotherapy (vinblastine and cyclophosphamide). METHODS: Phase III randomized …

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Factores pronósticos de sobrevida en niños con cáncer y neutropenia febril

Romina Valenzuela, Marı́a Elena Santolaya, Milena Villarroel, Gabriel Cavada et autres

Cancer remains one of the most important diseases in public health. OBJECTIVE: To estimate 5-year survival in pediatric cancer patients affected by FN, according to clinical-demographic variables. PATIENTS AND METHOD: Survival, prognostic, and analytical study with historical cohort. analytical. Cancer was grouped …

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International Society of Paediatric Oncology (SIOP) Global Mapping Program: Analysis of healthcare centers in countries of the Latin American Society of Pediatric Oncology (SLAOP)

Maite Gorostegui‐Obanos, Luisa Chantada, Neviçolino Pereira Carvalho Filho, Oscar R Gonzalez-Ramella et autres

BACKGROUND: The International Society of Paediatric Oncology Society Global Mapping Program aims to describe the local pediatric oncology capacities. Here, we report the data from Latin America. METHODS: A 10-question survey was distributed among chairs of pediatric oncology services. Centers were classified …

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