K.-H. Su

Analysis of Sensitivity Gains for BGO-Based TOF PET

Sangtae Ahn, Sergei Dolinsky, K.-H. Su, Kihong Kim et autres

Bismuth germanate (BGO) is a widely-used PET scintillator with many advantages over lutetium (yttrium) oxyorthosilicate (L(Y)SO), including higher stopping power, a higher photoelectric fraction, a lower cost and lower background radiation. Generally, BGO is considered to be unsuitable for time of flight …

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Auto-Beta: Deep Learning-Based Automatic Beta Parameter Selection for Penalized Ml Image Reconstruction

Abolfazl Mehranian, Scott D. Wollenweber, K.-H. Su, Roger H. Johnson et autres

The automatic selection of the regularisation parameter (beta) of PET penalised reconstruction algorithms such as block-sequential regularized expectation-maximization (BSERM) has been a long-standing challenge. Here, we propose a novel framework to automatically select a patientspecific noise-aware beta value using a deep convolutional …

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CT-free PET for Pediatric Patients with Metal Implants

Andrew T. Trout, K.-H. Su, J. MacLean, M.R. Syed et autres

Metal implants in pediatric sarcoma patients pose an inherent challenge for deep-learning (DL) based attenuation and scatter correction (ASC) in PET imaging. To address this issue, we developed a maximum a priori joint activity and attenuation (MAP-AA) PET reconstruction technique to integrate …

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Data-driven detection and correction of cardiac and respiratory motion in PET

A. Serieyssol, Matthew G. Spangler‐Bickell, Floris P. Jansen, K.-H. Su et autres

Cardiac PET images provide important diagnostic information on heart disease. Respiratory and cardiac movements of the heart can severely degrade image quality and impact the diagnostic accuracy of cardiac PET. The detection of respiratory and cardiac motions is essential to subsequently compensate …

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Optimized Monte-Carlo Scatter and Prompt Gamma Correction for WholeBody and Cardiac PET Imaging

X. Zhang, K.-H. Su, Floris P. Jansen

Accurate scatter correction is of great importance for quantitative PET imaging. However, the current widely used model-based scatter estimation methods on clinical PET scanners is prone to correction errors at some scenarios and result in artifacts. This situation becomes even worse when …

Time-Resolved Single-Step Protease Activity Quantification Using Nanoplasmonic Resonator Sensors

Cheng Sun, K.-H. Su, Jason Valentine, Yazmín T. Rosa‐Bauzá et autres

Protease activity measurement has broad application in drug screening, diagnosis and disease staging, and molecular profiling. However, conventional immunopeptidemetric assays (IMPA) exhibit low fluorescence signal-to-noise ratios, preventing reliable measurements at lower concentrations in the clinically important picomolar to nanomolar range. Here, we …

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Raman Enhancement Factor of a Single Tunable Nanoplasmonic Resonator

K.-H. Su, Stéphane Durant, Jennifer M. Steele, Yi Xiong et autres

We have developed a novel technique to precisely determine the Raman enhancement factor in single nanoplasmonic resonators (TNPRs). TNPRs are lithographically defined metallodielectric nanoparticles composed of two silver disks stacked vertically, separated by a silica layer. At resonance, the local electromagnetic fields …

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Tunable and augmented plasmon resonances of Au∕SiO2∕Au nanodisks

K.-H. Su, Qi‐Huo Wei, Xiang Zhang

The plasmon resonance of Au∕SiO2 multilayered nanodisks was studied using light scattering spectroscopy and numerical calculations. Compared to single layered Au nanodisks, multilayered nanodisks exhibit several distinctive properties including significantly enhanced plasmon resonances and tunable resonance wavelengths which can be tailored to …

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From nano-plasmonic optics toward molecules bio-sensing

K.-H. Su

Plasmon Resonance of Finite One-Dimensional Au Nanoparticle Chains

Qi‐Huo Wei, K.-H. Su, Stéphane Durant, Xiang Zhang

We report experimental and theoretical studies on the plasmon resonances of finite one-dimensional chains of Au nanoparticles excited by evanescent light waves with polarization parallel to the chains. The experimental results show that the plasmon resonance peak wavelengths of these finite 1D …

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Surface plasmon coupling between two nano Au particles

K.-H. Su, Qi‐Huo Wei, X. Zhang, Jack J. Mock et autres

Nano metal particles which interact strongly with visible light make themselves useful for molecular detection and biosensing. To facilitate the useful application for these nano particles, it is important to design and fabricate the particles at a desired frequency. In this paper, …

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Engineering 'hot spots' for surface-enhanced Raman scattering

Qi‐Huo Wei, K.-H. Su, Xiaoxiao Zhang, Xiang Zhang

Strong Raman signals have been observed in various molecules attached to rough metal film surfaces or nano silver/gold particles. This phenomenon is denoted as surface enhanced Raman scattering (SERS). Recent experiments have shown that the effective cross sections of Raman scattering can …

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