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Ken-Kuo Lin, Nivetha Ganesan, Yan Ma, Ting‐Chang Chang et autres
Conclusions: Despite the finding that nodal TFH lymphomas develop on a background of CH, the cumulative incidence of subsequent MN is relatively low.This finding may be due to a high competing risk of death from lymphoma, use of allogeneic transplant in the …
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Efrat Luttwak, Esther Drill, Nivetha Ganesan, Liron Hofstetter et autres
Introduction: Despite favorable outcomes in younger pts with cHL, those aged ≥ 60, have inferior survival, due to disease biology (e.g., mixed cellularity, EBVþ, advanced-stage disease) and comorbidities impacting treatment-related toxicity.Brentuximab vedotin (BV) plus AVD (doxorubicin, vinblastine, dacarbazine) is approved for frontline …
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Pallawi Torka, Ashlee Joseph, Philip Caron, Kevin A. David et autres
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Rita Tavarozzi, Michelle Okwali, Maria E. Arcila, Annie Qiu et autres
rearrangement would have a prognostic impact, the high variability in the non-IgH MYC partner requires further investigation of the impact of these fusion genes.
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Alfredo Rivas‐Delgado, Feng Xu, A. Bowman, Richard B. Brannon et autres
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Amira Marouf, Simon Grassmann, Jahan Rahman, Nivetha Ganesan et autres
endpoint was progression-free survival (PFS).CD/RCD status was confirmed by duodenal histology, flow cytometry and TCR gene rearrangement of IELs, celiac serology, and HLA typing.Results: Between February 2018 and February 2021, 14 patients were enrolled (median age: 54 years [34-65]; 64% male).Eleven underwent …
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Danilo Fiore, Luca Vincenzo Cappelli, Nikita Kotlov, Maria Sorokina et autres
Peripheral T cell lymphomas (PTCLs) comprise heterogeneous malignancies with limited therapeutic options. To uncover targetable vulnerabilities, we generate a collection of PTCL patient-derived tumor xenografts (PDXs) retaining histomorphology and molecular donor-tumor features over serial xenografting. PDX demonstrates remarkable heterogeneity, complex intratumor architecture, …
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Danilo Fiore, Luca Vincenzo Cappelli, Zhaoqi Liu, Nikita Kotlov et autres
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Jia Ruan, John P. Leonard, Melanie Coleman, Sarah C. Rutherford et autres
Introduction: Peripheral T-cell lymphomas (PTCL) are an uncommon and heterogeneous group of non-Hodgkin lymphomas with divergent cells of origin and mechanisms of lymphomagenesis. Cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP) chemotherapy, the most commonly prescribed initial treatment for systemic PTCL, provides suboptimal complete …
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Sabela Bobillo, Erel Joffe, Jessica A. Lavery, Ariela Noy et autres
78% RT vs. 72% no RT (p = 0.047); 10y OS 77% RT vs
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Connie Lee Batlevi, Anna Alperovich, Ai Ni, Jacob D. Soumerai et autres
Introduction: Management of follicular lymphoma (FL) requires multiple lines of therapy despite improved outcomes. We sought to 1) define treatment outcomes after multiple lines of therapy and 2) examine impact of FLIPI score changes on the outcome of initially observed patients. Methods: …
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Matthew A. Lunning, Eric G. Pamer, Jocelyn Maragulia, David J. Straus et autres
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