Ylva Lindroth

Assessment of Chlamydia trachomatis testing in Sweden 2016–2023 and the incidence of associated complications

Siri Westborg, Karin Elfving, Ylva Lindroth, Lisa Stark et autres

BACKGROUND: This study aimed to assess chlamydia diagnostics in different clinic types, including internet-based self-sampling (IBSS). Furthermore, we investigated the incidence of chlamydia-associated complications. METHODS: (CT) testing were retrieved from six healthcare regions in the years 2016-2023 across different categories of testing …

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An automated commercial open access assay for detection of Mycoplasma genitalium macrolide resistance

Ylva Lindroth, Lucia Hansson, Ola Forslund

Azithromycin, a macrolide antibioticum, is the first-line treatment for Mycoplasma genitalium (MG), but resistant MG is an increasing problem. Macrolide resistance-mediated mutations (MRM) has been linked to point mutations in region V of the MG 23S rRNA gene. We have evaluated an …

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Seroprevalence of tick-borne encephalitis virus and vaccination coverage of tick-borne encephalitis, Sweden, 2018 to 2019

Bo Albinsson, Tove Hoffman, Linda Kolstad, Tomas B. Bergström et autres

BackgroundIn Sweden, information on seroprevalence of tick-borne encephalitis virus (TBEV) in the population, including vaccination coverage and infection, is scattered. This is largely due to the absence of a national tick-borne encephalitis (TBE) vaccination registry, scarcity of previous serological studies and use …

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Cervix cytology samples revealed increased methylation of the human markers FAM19A4 / miR124‐2 up to 8 years before adenocarcinoma

Ylva Lindroth, Louise Pedersen, Jacob Alssamaray, Avalon Sundqvist et autres

INTRODUCTION: Methylation analysis of the promoter region of tumor-suppressor genes has previously shown high sensitivity for detection of high-grade cervical intraepithelial neoplasia (CIN) and cancer. HPV-testing has a high sensitivity to identify women at risk to develop cancer, and has been implemented …

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The risk for celiac disease after Covid-19 infection

Jesper Lexner, Ylva Lindroth, Klas Sjöberg

BACKGROUND: Celiac disease (CD) is an autoimmune disease leading to gastrointestinal symptoms and mineral deficiencies. The pathogenetic mechanisms, besides the clear HLA association, are elusive. Among environmental factors infections have been proposed. Covid-19 infection results in a systemic inflammatory response that often …

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First National Genomic Epidemiological Study of Neisseria gonorrhoeae Strains Spreading Across Sweden in 2016

Ronza Hadad, Daniel Golparian, Inga Veličko, Anna-Karin Ohlsson et autres

The increasing transmission and antimicrobial resistance (AMR) in Neisseria gonorrhoeae is a global health concern with worrying trends of decreasing susceptibility to also the last-line extended-spectrum cephalosporin (ESC) ceftriaxone. A dramatic increase of reported gonorrhea cases has been observed in Sweden from …

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P291 Genomic epidemiology of Neisseria gonorrhoeae isolates in Sweden – 2016 national study

Ronza Hadad, Daniel Golparian, Inga Veličko, Ylva Lindroth et autres

Background The number of reported cases of gonorrhoea in Sweden continuously increased from an incidence of 7.8 per 100 000 inhabitants in 2009 to 31.4 in 2019. The largest increase in incidence was observed during 2016–2017. No national molecular epidemiological study investigating …

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Rapid diagnostic testing for SARS‐CoV‐2: Validation and comparison of three point‐of‐care antibody tests

Rasmus Strand, Louise Thelaus, Nils Fernström, Torgny Sunnerhagen et autres

With the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a need for diagnostic tests has surfaced. Point-of-care (POC) antibody tests can detect immunoglobulin (Ig) G and M against SARS-CoV-2 in serum, plasma, or whole blood and give results within 15 …

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Systematic evaluation of SARS‐CoV‐2 antigens enables a highly specific and sensitive multiplex serological COVID‐19 assay

Sophia Hober, Cecilia Hellström, Jennie Olofsson, Eni Andersson et autres

OBJECTIVE: The COVID-19 pandemic poses an immense need for accurate, sensitive and high-throughput clinical tests, and serological assays are needed for both overarching epidemiological studies and evaluating vaccines. Here, we present the development and validation of a high-throughput multiplex bead-based serological assay. …

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Finnish new variant of Chlamydia trachomatis escaping detection in the Aptima Combo 2 assay also present in Örebro County, Sweden, May 2019

Magnus Unemo, Marit Hansen, Ronza Hadad, Ylva Lindroth et autres

We identified the first two cases of the Finnish new variant of Chlamydia trachomatis (F-nvCT) beyond Finland in two clinical urogenital specimens in Örebro County, Sweden. These Aptima Combo 2 assay-negative specimens were Aptima Chlamydia trachomatis (CT) assay positive and had the …

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Population-based primary HPV mRNA cervical screening compared with cytology screening

Ylva Lindroth, Christer Borgfeldt, Gunilla Thorn, Gunilla Bodelsson et autres

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Spectrum of HPV types before and after treatment of cervical intraepithelial neoplasia grade 2 and 3

Ylva Lindroth, Kaj Bjelkenkrantz, Ola Forslund

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