Thomas Wilke

Long-term prophylactic treatment and related real-world outcomes of patients with hereditary angioedema in Germany: A retrospective analysis of German claims and medical chart data

Jens Greve, Nils Picker, Fabian Jülich, Verena Donatz et autres

Background Hereditary angioedema (HAE) is a rare genetic disorder characterized by recurrent swelling episodes that are potentially life threating and substantially impair quality of life. This study aimed to generate real-world evidence on the utilization of long-term prophylaxis (LTP), residual disease burden, …

de, ch (code pays fourni par la source)

Association between proton pump inhibitor co-medication and treatment switching in dasatinib-treated patients with chronic myeloid leukemia: a German real-world evidence study

S. Mueller, Chen-Chia Pan, Jan Bosak, Jiří Hofmann et autres

Dasatinib absorption is pH-dependent, and concomitant use of Proton Pump Inhibitors (PPIs) can substantially reduce dasatinib exposure. Whether this interaction has clinical relevance and affects treatment outcomes in patients with chronic myeloid leukemia (CML) remains unclear. This retrospective cohort study used German …

de, cz (code pays fourni par la source)

Conformity with guideline-directed medical therapy and clinical outcomes in secondary cardiovascular prevention—results of a German claims data analysis

Sven Waßmann, Burkhard Weisser, Thomas Wilke, Antje Mevius et autres

AIMS: Clinical guidelines for secondary cardiovascular (CV) prevention provide recommendations for medical treatment to improve patient prognosis. This retrospective German study aimed to identify the level of guideline implementation in patients suffering from myocardial infarction (MI), stroke or transient ischemic attack (TIA), …

de (code pays fourni par la source)

EPH260 Trends in Epidemiology and Mortality of Patients With Bladder Cancer in Germany: A Retrospective Study Using German Claims Data

Antje Mevius, Benjamin Birkner, Thomas Wilke

de (code pays fourni par la source)

Impact of community-acquired invasive Escherichia coli disease on mortality and readmissions in elderly patients: a multi-center study in Germany

Fruzsina Kósa, Olaf Radunz, Jeroen Geurtsen, Michal Sarnecki et autres

BACKGROUND: Extraintestinal pathogenic Escherichia coli (ExPEC) causes invasive E. coli disease (IED), resulting in significant morbidity and mortality, particularly among the elderly. IED can present as bacteremia or sepsis and poses serious health risks for adults aged ≥ 60 years, compounded by …

hu, de, nl, ch (code pays fourni par la source)

Reporting of management and outcomes in the hemolytic disease of the fetus and newborn: a systematic literature review

E. J. T. Verweij, Enrico Lopriore, Marie Fitzgibbon, Thomas Wilke et autres

OBJECTIVE: This systematic literature review aimed to identify outcomes and provide a foundation for the development of a core outcome set in HDFN applicable for use in future clinical trials. STUDY DESIGN: The bibliographic databases MEDLINE, Embase, EBM Reviews, and EconLit were …

nl, be, us (code pays fourni par la source)

Epidemiology and treatment patterns of essential tremor: a retrospective cohort analysis in Germany

Jos Steffen Becktepe, Keltie C McDonald, S. Mueller, Thomas Wilke et autres

Background: Real-world evidence on the epidemiology, clinical characteristics, and treatment patterns of patients with essential tremor (ET) is limited. We used data from two large representative German claims databases to address this evidence gap. Methods: Data were obtained from two German statutory …

de, us, gb (code pays fourni par la source)

COVID-19 Disease Burden in the Omicron Variant-Dominated Endemic Phase: Insights from the ROUTINE-COV19 Study Using Real-World German Statutory Health Insurance Data

S. Mueller, A Schmetz, Julia K. Knaul, Thomas Wilke et autres

The ROUTINE-COV19 study explores the burden of COVID-19 in Germany during the early endemic phase, assessing disease patterns and their impact on the healthcare system from 1 July 2022 to 30 June 2023. Using anonymized statutory health insurance data from over 3 …

de, us (code pays fourni par la source)

Djoser the father of Pyramid building

Thomas Wilke, Buch & Media GmbH

EPH47 Trends in Epidemiology and Mortality of Patients With Prostate Cancer in Germany: A Retrospective Study Using German Claims Data

Stephan G. Müller, S Dornig, Thomas Wilke, Antje Mevius

de (code pays fourni par la source)

HPR138 Analysis of Health Technology Assessments of Lung Cancer Therapies in Germany in the Last Decade: Is There an Association Between Added Benefit Ratings and Negotiated Reimbursement Prices?

Nils Picker, S Müller, Thomas Wilke

de (code pays fourni par la source)

EPH278 Trends in Epidemiology and Mortality of Patients With Lung Cancer in Germany: A Retrospective Study Using German Claims Data

Thomas Wilke, Antje Mevius, S Müller, S Dornig

de (code pays fourni par la source)