Zhuo Yu

A Sparse Corner-Difference MILP for Minimum Square Tiling

Zhuo Yu, Yuan Wang, Zhuo Liu

We study the problem of tiling an $N\times N$ square with axis-aligned squares whose side lengths are integers strictly less than $N$, with the objective of minimizing the number of tiles. The standard placement-based exact-cover MILP contains $Θ(N^5)$ placement-to-cell nonzero coefficients and …

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ABCB1 rs2032582 as a potential biomarker for predicting Scutellaria baicalensis Georgi–drug induced liver injury in humans

Lihong Fu, Longshan Ji, Xiaji Yan, Wanchun Zhu et autres

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Vorinostat nanoformulation triggers cell cycle blockade and apoptosis for colorectal cancer therapy

Leilei Yang, Tingting Guo, Junjun Chen, Yifang Zou et autres

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Gut microbiota-metabolism-immunity axis: a novel perspective of traditional Chinese medicine in hepatocellular carcinoma treatment

Xuemei Zhang, Liming Zheng, Jia Shi, Shihan Yu et autres

Hepatocellular carcinoma (HCC) is a highly aggressive malignancy characterized by complex metabolic dysregulation and immune evasion mechanisms, leading to poor prognosis and limited treatment efficacy. Growing evidence underscores the critical involvement of gut microbiota dysbiosis in HCC pathogenesis, wherein microbial communities and …

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Activated hepatic stellate cell-derived exosomal miR-23a-3p promotes hepatocellular carcinogenesis by regulating DUSP5/ERK signaling

Xiaona Lu, Jia Shi, Wenlan Zheng, Shihan Yu et autres

INTRODUCTION: Activation of hepatic stellate cells (HSCs) is a core driver of liver fibrosis and may contribute to the evolution to hepatocellular carcinoma (HCC). Exosomes mediate intercellular signaling by transporting bioactive molecules, yet the role of activated HSC-derived exosomes in hepatocarcinogenesis remains …

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Circadian disruption in hepatocellular carcinoma: Current findings and future directions of molecular mechanisms

Liming Zheng, Xuemei Zhang, Hai Feng, Jianfeng Guo et autres

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Endoscopic Submucosal Dissection for Early Esophageal Squamous Cell Carcinoma Located at Esophageal Varices Caused by Liver Cirrhosis

Wenlan Zheng, Jinzhong Yu, Kun Liu, Xiaona Lu et autres

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Nanodelivery of panobinostat induces cell cycle arrest and apoptosis to suppress hepatocellular carcinoma growth in mice

Yutong Li, Dong Li, Junjun Chen, Yuqiong Gao et autres

Hepatocellular carcinoma (HCC), the predominant subtype of primary liver cancer, remains as a globally lethal malignancy with limited therapeutic options. Despite therapeutic efficacy of small-molecule inhibitors, the majority of HCC patients are still incurable due to suboptimal response rate and serious systemic …

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Anti-stromal nanotherapeutics for hepatocellular carcinoma

Jianfeng Guo, Zhuo Yu, Leaf Huang

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Newly Established Anoikis-Associated Genes Predict the Prognosis of Hepatocellular Carcinoma

Yuyao Li, Li Er, Wenlan Zheng, Jia Shi et autres

Objective: Anoikis is an anchorage-dependent programmed cell death implicated in multiple pathological processes of cancers; however, the prognostic value of anoikis-related genes (ANRGs) in hepatocellular carcinoma (HCC) remains unclear. Our study aims to develop an ANRGs-based prediction model to improve prognostic assessment …

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Assessment of cognitive function in patients with schizophrenia based on virtual reality serious games: a prospective nonrandomized clinical trial

Chenxin Wu, Zhuo Yu, Jianying Yu, Xingxing Li et autres

Introduction Conventional neuropsychological tests for assessing cognitive function in schizophrenia face critical limitations in ecological validity and efficiency. We developed Fruit Pioneer, a virtual reality serious game simulating real-world cognitive demands, to address these challenges. This study aimed to validate its diagnostic …

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Chromosome-level genome assembly of Triplophysa scleroptera

Xiu Feng, Ren Zhu, Yintao Jia, Xiaoyun Sui et autres

Triplophysa scleroptera is an endemic fish species in Qinghai Lake and the upper reaches of the Yellow River. However, studies on conservation and evolutionary genetics were seriously impeded by the absence of a reference genome. Here, by using PacBio HiFi sequencing and …

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