Narayanan Janakiraman

TCF4 trinucleotide repeat expansion drives distinct proteomic signatures in Fuchs endothelial corneal dystrophy

Taichi Yuasa, Tatsuya Nakagawa, Tetsuro Honda, Go Nishiuchi et autres

Abstract The aims of this study were to use an isogenic cell model system to investigate the proteomic consequences of TCF4 trinucleotide repeat expansion in Fuchs endothelial corneal dystrophy (FECD) and to identify potential molecular pathways contributing to disease pathogenesis. We used …

jp, de, in (code pays fourni par la source)

Contributors

Mohamed N. Abd El-Ghany, Amith Abraham, Nahdhoit Ahamada Rachid, Israr Ahmed et autres

Aptamers applications with focus on detection and remediation of contaminants of emerging concerns

Jayasree Balasubramanyam, Sukanya Madan Mohan, Narayanan Janakiraman, Sailaja V. Elchuri

in (code pays fourni par la source)

Artificial intelligence potential to improve soil organic matter in climate change

Kaushik Parthasarathi, Narayanan Janakiraman, Jyoti Sharma, Sailaja V Elchuri

in (code pays fourni par la source)

List of contributors

Sharon R. Aarons, Amos Adeniyi, Jitendra Ahirwal, Paula Alvarenga et autres

au, Afrique du Sud, in, pt, br, de, pl, cz, es, ca, th (code pays fourni par la source)

Unveiling the Therapeutic Potential: A Peptide Drug Conjugate’s Influence on Transcription and Translation in Ocular Fibrosis Modulation

Jayavigneeswari Suresh Babu, Kiran Bharat Gaikwad, Jyoti Sharma, Sailaja V Elchuri et autres

Fibrosis is a major challenge in glaucoma management, particularly following surgical interventions like trabeculectomy. In this study, we explored the therapeutic potential of a fibrosis-modulating peptide (VRF2019) and its mitomycin conjugate by evaluating their transcriptomic impact on primary Tenon fibroblast cells isolated …

in, cz, us, gb (code pays fourni par la source)

Mango ginger-derived exosome-like nanovesicles promotes diabetic wound healing via inducing the promigratory protein, follistatin-like 1.

A Suresh, Jahnavi Ravilla, Narayanan Janakiraman, Gopinath Meenakshi Sundaram

in (code pays fourni par la source)

Corrigendum to “Fenugreek-derived exosome-like nanovesicles containing bioavailable phytoferritin for the management of iron deficiency anemia” [Food Chem. 490 (2025) 145088]

Cathrine M S Bethi, Meghana N. Kumar, Sreeram Peringattu Kalarikkal, Narayanan Janakiraman et autres

in (code pays fourni par la source)

Plant-Derived Nanovesicles from Soaked Rice Water: A Novel and Sustainable Platform for the Delivery of Natural Anti-Oxidant γ-Oryzanol

Jahnavi Ravilla, Soundaram Rajendran, Vidya M. Basavaraj, Greeshma Satheeshan et autres

Gamma oryzanol (GO) is a natural anti-oxidant found in rice bran with potential health benefits. Conventional isolation of GO from rice bran requires the use of non-eco-friendly solvents such as acetone, ethyl acetate and hexane due to its low aqueous solubility. Further, …

in (code pays fourni par la source)

Nanocarrier potential of small cardamom-derived exosome-like nanovesicles for the delivery of appetite-enhancing peptide, Ghrelin

Soundaram Rajendran, Yashaswini Jayaram, Narayanan Janakiraman, Gopinath Meenakshi Sundaram

in (code pays fourni par la source)

Natural plant-derived nanovesicles for effective psoriasis therapy via dual modulation of IL-17 and NRF2 pathway

Sreeram Peringattu Kalarikkal, Meghana N. Kumar, Sriram Thoppe Rajendran, Cathrine M S Bethi et autres

assay, both shallot and garlic PDNVs displayed percutaneous penetration up to the suprabasal epidermis. Using next generation sequencing and quantitative mRNA profiling in keratinocytes and murine skin, we elucidated a suppressive effect of shallot and garlic PDNVs on IL-17 signaling via modulation …

in (code pays fourni par la source)

The TCF4 Gene Regulates Apoptosis of Corneal Endothelial Cells in Fuchs Endothelial Corneal Dystrophy

Tatsuya Nakagawa, Tetsuro Honda, Taichi Yuasa, Go Nishiuchi et autres

Purpose: Fuchs endothelial corneal dystrophy (FECD) is a progressive corneal disorder characterized by excessive extracellular matrix (ECM) accumulation and corneal endothelial cell death. CTG trinucleotide repeat expansion in the transcription factor 4 (TCF4) gene represents the most significant genetic risk factor. This …

jp, de, in, gb (code pays fourni par la source)