Bruce F. Kimler

Metabolic and transcriptional effects of bazedoxifene/conjugated estrogens in a model of obesity-associated breast cancer risk

Katherine Sánchez, Barry S. Komm, Alina Levin, Katherine L. Cook et autres

Many risk-eligible women refuse tamoxifen for primary prevention of breast cancer due to concerns about common side effects such as vasomotor symptoms. Tamoxifen may also induce or worsen insulin resistance and hypertriglyceridemia, especially in women with obesity. Bazedoxifene/conjugated estrogens (BZA/CE) reduces vasomotor …

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Supplementary Figure S4 from Weight Loss and Omega-3 Supplementation Modulate the Microbiome in Women with Increased Breast Cancer Risk

Katherine Loree Cook, Erin Danielle Giles, Josh J. Sekela, Joshua B. Simpson et autres

Supplementary Figure S4. α and β diversity indexes in patients by menopause and hormone replacement therapy use in the 6-month fecal samples. A. Shannon index B. Bray-Curtis β-diversity principal coordinate analysis (PCoA).

Supplementary Figure S1 from Weight Loss and Omega-3 Supplementation Modulate the Microbiome in Women with Increased Breast Cancer Risk

Katherine Loree Cook, Erin Danielle Giles, Josh J. Sekela, Joshua B. Simpson et autres

Supplementary Figure S1. Workflow Chart Describing Fecal Metagenomic Sequencing Processing for Microbial GUS Gene Analysis by Loop Structure Classifications.

Supplementary Table S1 from Weight Loss and Omega-3 Supplementation Modulate the Microbiome in Women with Increased Breast Cancer Risk

Katherine Loree Cook, Erin Danielle Giles, Josh J. Sekela, Joshua B. Simpson et autres

Supplementary Table S1. Baseline characteristics for women in the weight loss intervention who had 6- month fecal samples available for analysis. Mean ± SD; (range).

Supplementary Table S2 from Weight Loss and Omega-3 Supplementation Modulate the Microbiome in Women with Increased Breast Cancer Risk

Katherine Loree Cook, Erin Danielle Giles, Josh J. Sekela, Joshua B. Simpson et autres

Supplementary Table S2. Representativeness of Study Participants

Supplementary Figure S3 from Weight Loss and Omega-3 Supplementation Modulate the Microbiome in Women with Increased Breast Cancer Risk

Katherine Loree Cook, Erin Danielle Giles, Josh J. Sekela, Joshua B. Simpson et autres

Supplementary Figure S3. α and β diversity indexes in patients with matched baseline and 6-month fecal samples. A. Shannon index B. Bray-Curtis β-diversity principal coordinate analysis (PCoA).

Data from Weight Loss and Omega-3 Supplementation Modulate the Microbiome in Women with Increased Breast Cancer Risk

Katherine Loree Cook, Erin Danielle Giles, Josh J. Sekela, Joshua B. Simpson et autres

Abstract Obesity is associated with gut dysbiosis, chronic inflammation, and insulin resistance. We assessed the proportional change in fecal microbial populations in a pilot study (n = 34) of peri/postmenopausal women with a body mass index ≥28 kg/m2 who were randomized to …

Supplementary Figure S5 from Weight Loss and Omega-3 Supplementation Modulate the Microbiome in Women with Increased Breast Cancer Risk

Katherine Loree Cook, Erin Danielle Giles, Josh J. Sekela, Joshua B. Simpson et autres

Supplementary Figure S5. α and β diversity indexes in patients by age in the 6-month fecal samples. A. Shannon index B. Bray-Curtis β-diversity principal coordinate analysis (PCoA).

Supplementary Figure S2 from Weight Loss and Omega-3 Supplementation Modulate the Microbiome in Women with Increased Breast Cancer Risk

Katherine Loree Cook, Erin Danielle Giles, Josh J. Sekela, Joshua B. Simpson et autres

Supplementary Figure S2. Red blood cell (RBC) n-6:n-3 PUFA ratios. A. Women randomized to placebo did not display differences in erythrocyte phospholipid ratio of n-6:n-3 PUFA. B. Women randomized to omega-3 displayed a significantly reduced erythrocyte phospholipid ratio of n-6:n-3 PUFA. C. …

Weight Loss and Omega-3 Supplementation Modulate the Microbiome in Women with Increased Breast Cancer Risk

Katherine Loree Cook, Erin Danielle Giles, Josh J. Sekela, Joshua B. Simpson et autres

Obesity is associated with gut dysbiosis, chronic inflammation, and insulin resistance. We assessed the proportional change in fecal microbial populations in a pilot study (n = 34) of peri/postmenopausal women with a body mass index ≥28 kg/m2 who were randomized to receive …

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Pathological Response and Survival in Triple-Negative Breast Cancer Following Neoadjuvant Carboplatin plus Docetaxel

José Á. García-Sáenz, Sara López‐Tarruella, Hugo Alejandro Fuentes, Qamar J. Khan et autres

PURPOSE: Prognostic value of pathologic complete response (pCR) and extent of pathologic response attained with anthracycline-free platinum plus taxane neoadjuvant chemotherapy (NAC) in triple-negative breast cancer (TNBC) is unknown. We report recurrence-free survival (RFS) and overall survival (OS) according to degree of …

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Analysis of the Radiosensitivity Index in Paired Preneoadjuvant and Postneoadjuvant Therapy Triple-Negative Breast Cancer

Shane Richard Stecklein, Roberto Salgado, Julia R. White, Bruce F. Kimler et autres

PURPOSE: The radiosensitivity index (RSI) is a validated gene expression-based biomarker that can predict intrinsic radiosensitivity and has been shown to be associated with local control in patients with triple-negative breast cancer (TNBC) treated with upfront surgery. Currently, most patients with TNBC …

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