Chaewon Shin

When machines see more: Digital technologies, measurement, and meaning in hyperkinetic movement disorders

Roongroj Bhidayasiri, Chaewon Shin, Alberto Albanese

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Opicapone for the Treatment of Nocturnal Hypokinesia in Patients With Parkinson’s Disease: An Open-Label Pilot Clinical Trial

Chaewon Shin, Jong‐Min Kim

Nocturnal hypokinesia (NH) is common in patients with moderate-stage Parkinson's disease (PD). This open-label, single-arm pilot study aimed to assess the effect of bedtime opicapone administration on NH and to evaluate the clinical utility of the Nocturnal Hypokinesia Questionnaire (NHQ). The primary …

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Exploring retinoic acid-induced skin irritation: Pathological and mechanistic insights from an ex vivo porcine skin model

Jee-hyun Hwang, Sumin Hur, Chaewon Shin, H. Kim et autres

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Correction: Distinct spatial transcriptomic patterns of substantia Nigra in Parkinson disease and Parkinsonian subtype of multiple system atrophy

Jung Hwan Shin, Karoliina Eliisa Ruhno, Chaewon Shin, Hyun Je Kim et autres

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Cognitive function correlates with gastric alpha-synuclein seeding activity in early Parkinson’s disease

Chaewon Shin, Jong Pil Im, Jung‐Youn Han, Bora Jin et autres

Alpha-synuclein (AS) accumulation is more frequently detected in the stomach than in the colon of patients with Parkinson's disease (PD), suggesting its potential as a pathologic biomarker. This study is to evaluate the diagnostic performance of real-time quaking-induced conversion assay on stomach …

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Assessing Digital Health Technologies for Outcome Measurement in Parkinson's Disease Drug Trials: A Systematic Review

Sasivimol Virameteekul, Chaewon Shin, Siegfried Hirczy, Harini Sarva et autres

Traditional clinical assessments in Parkinson's disease (PD) trials are limited by subjectivity and inter-rater variability. Digital health technologies (DHT) offer an objective continuous assessment of motor symptoms and are increasingly used in clinical research. This review evaluated the role of DHTs as …

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Distinct spatial transcriptomic patterns of substantia Nigra in Parkinson disease and Parkinsonian subtype of multiple system atrophy

Jung Hwan Shin, Karoliina Eliisa Ruhno, Chaewon Shin, Hyun Je Kim et autres

To investigate transcriptomic signatures of Parkinson's disease (PD) and the Parkinsonian subtype of Multiple System Atrophy (MSA-P) in substantia nigra pars compacta (SNpc), we conducted transcriptome analysis using in-situ hybridization on paraffin-embedded SNpc tissues from post-mortem brains. The study included 2 MSA-P …

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Spatial transcriptome analysis of myenteric plexus and intestinal epithelium of colon in patients with Parkinson’s disease

Chaewon Shin, Karoliina Eliisa Ruhno, Jung Hwan Shin, Sanha Hwang et autres

Alpha-synuclein (AS) accumulation is found in the nerve plexuses of the gastrointestinal tract in patients with Parknison's disease (PD). Moreover, alterations in microbiome composition and its metabolites were confirmed in the colon of patients with PD. However, there has been no study …

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Efficacy of Levodopa/Benserazide Dispersible Tablets on “Delayed ON ” to the First Morning Dose in Patients With Parkinson’s Disease With Motor Fluctuations: A Multicenter, Randomized, Open-Label, Crossover Trial

Hee Jin Chang, Jongkyu Park, Sohee Oh, Chaewon Shin et autres

OBJECTIVE: Delayed ON is a condition in which Parkinson's disease (PD) patients do not experience the effect of levodopa in time after taking the dosage. The ability of various oral levodopa regimens to overcome this problem has been poorly investigated. To evaluate …

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Distinct spatial transcriptomic patterns of substantia nigra in Parkinson disease and Parkinsonian subtype of multiple system atrophy

Jung Hwan Shin, Karoliina Eliisa Ruhno, Chaewon Shin, Hyun Je Kim et autres

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Validation of the Korean Version of the Huntington’s Disease Quality of Life Battery for Carers

Hee Jin Chang, Eungseok Oh, Won Tae Yoon, Chan Young Lee et autres

OBJECTIVE: The Huntington's Disease Quality of Life Battery for Carers (HDQoL-C) is used to evaluate caregiver quality of life. This study aimed to develop and validate the Korean version of the HDQoL-C (K-HDQoL-C) to assess the burden on Korean caregivers of Huntington's …

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A Practical Guide for Diagnostic Investigations and Special Considerations in Patients With Huntington’s Disease in Korea

Jangsup Moon, Eungseok Oh, Minkyeong Kim, Ryul Kim et autres

This review provides a comprehensive framework for the diagnostic approach and management of Huntington's disease (HD) tailored to the Korean population. Key topics include genetic counseling, predictive testing, and reproductive options like preimplantation genetic testing. Strategies for assessing disease progression in premanifest …

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