Peter Bacchetti

Galectin 9 Levels as a Potential Predictor of Intact HIV Reservoir Decay

Sergio Serrano‐Villar, Akshay Gala, Peter Bacchetti, Rebecca Hoh et autres

BACKGROUND: During antiretroviral therapy (ART), the HIV reservoir shows variability, with cells carrying intact genomes decaying faster than those with defective genomes, particularly in the first years. The host factors influencing this decay remain unclear. METHODS: Observational study of 74 PWH on …

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Food insecurity is associated with lower levels of antiretroviral drug concentrations in hair among a cohort of women living with human immunodeficiency virus in the United States

M.H. Cohen, D. Merenstein, T.E. Wilson, Lila A. Sheira et autres

Background. Food insecurity is a well-established determinant of suboptimal, self-reported antiretroviral therapy (ART) adherence, but few studies have investigated this association using objective adherence measures. We examined the association of food insecurity with levels of ART concentrations in hair among women living …

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Pivoting from in-person to phone survey assessment of alcohol and substance use: effects on representativeness in a United States prospective cohort of women living with and without HIV

Hannah Tierney, Yifei Ma, Peter Bacchetti, Adaora A. Adimora et autres

Background: Many clinical and population-based research studies pivoted from in-person assessments to phone-based surveys due to the COVID-19 pandemic. The impact of these transitions on survey response remains understudied, especially for people living with HIV. Given that there are gender-specific trends in …

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Use of Nonantiretroviral Medications That May Impact Neurocognition: Patterns and Predictors in a Large, Long-Term HIV Cohort Study

Ruth M. Greenblatt, David E. Vance, Kathleen M. Weber, Anandi N. Sheth et autres

Background: Neurocognitive impairment is a frequent and often disabling comorbidity of HIV infection. In addition to antiretroviral therapies, individuals with HIV infection may commonly use nonantiretroviral medications that are known to cause neurocognitive adverse effects (NC-AE). The contribution of NC-AE to neurocognitive …

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Body Composition Changes Over the Menopausal Transition in Women With and Without Human Immunodeficiency Virus

Rebecca Abelman, Thuy Trang J Nguyen, Yifei Ma, Peter Bacchetti et autres

BACKGROUND: Women are at risk for weight gain during the transition to menopause, but few have examined the contribution of menopause to weight gain in women with human immunodeficiency virus (WWH). METHODS: From 2000 to 2013, participants (621 WWH; 218 without HIV …

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Galectin-9 Levels as a Potential Predictor of Intact HIV Reservoir Decay

Sergio Serrano‐Villar, Akshay Gala, Peter Bacchetti, Rebecca Hoh et autres

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1903. Factors associated with response to a phone-administered alcohol and substance use survey during the COVID-19 pandemic among women in the MACS/WIHS Combined Cohort Study: Who are we missing?

Hannah Tierney, Yifei Ma, Peter Bacchetti, Ralph J. DiClemente et autres

Abstract Background Early in the COVID-19 pandemic, many clinical studies pivoted to remote research visits, which have a higher non-response rate compared to in-person assessments. Survey non-response can bias estimates of alcohol and substance use prevalence. Our objective was to identify factors …

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Antiretroviral Therapy Adherence During and Postbreastfeeding Cessation Measured by Tenofovir Levels in Hair

Teacler Nematadzira, Pamela M. Murnane, Osamuedeme J. Odiase, Peter Bacchetti et autres

BACKGROUND: We examined change in antiretroviral treatment (ART) adherence after breastfeeding (BF) cessation using hair tenofovir (TFV) concentrations as an objective metric of medication consumption. METHODS: A subset of postpartum women in Zimbabwe randomized in IMPAACT PROMISE to take ART while BF …

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Longitudinal Assessment of the Enhanced Liver Fibrosis Score in the Era of Contemporary HIV and Hepatitis C Virus Treatment

Annelys Roque Gardner, Yifei Ma, Peter Bacchetti, Jennifer C. Price et autres

BACKGROUND: The trajectory of liver fibrosis is not well understood in the contemporary era of human immunodeficiency virus (HIV) and hepatitis C virus (HCV) therapy. METHODS: We assessed the Enhanced Liver Fibrosis (ELF) score, aspartate transaminase-to-platelet ratio index (APRI) and Fibrosis-4 (FIB-4) …

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Distinct forms of migration and mobility are differentially associated with HIV treatment adherence

Pamela M. Murnane, Monica Gandhi, Peter Bacchetti, Monica Getahun et autres

OBJECTIVE: We examined whether human mobility was associated with antiretroviral treatment adherence, measured via antiretroviral hair concentrations. DESIGN: This is a cross-sectional analysis of adults on antiretroviral treatment in East Africa at baseline in an observational cohort study. METHODS: Participants reported recent …

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Disentangling the impact of alcohol use and hepatitis C on insulin action in Latino individuals

Rebecca G. Kim, Jonathan Kramer‐Feldman, Peter Bacchetti, Barbara Grimes et autres

BACKGROUND: Alcohol, insulin resistance (IR), and hepatitis C (HCV) are all significant contributors to adverse outcomes of chronic liver disease. Latinos are disproportionately affected by these risk factors. We investigated the relationship between alcohol use and insulin action in a prospective cohort …

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Multiply spliced HIV RNA is a predictive measure of virus production ex vivo and in vivo following reversal of HIV latency

Jennifer M. Zerbato, Georges Khoury, Wei Zhao, Matthew J. Gartner et autres

BACKGROUND: One strategy being pursued to clear latently infected cells that persist in people living with HIV (PLWH) on antiretroviral therapy (ART) is to activate latent HIV infection with a latency reversing agent (LRA). Surrogate markers that accurately measure virus production following …

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