Profil bibliographique

Yue Cheng Yang

Informations fournies par OpenAlex. Research Africa ne déduit ni nationalité, ni poste, ni coordonnées personnelles.

131Publications signalées

2608Citations signalées

1Affiliations récentes

Les institutions déclarées

Les domaines associés

Protein Kinase Regulation and GTPase SignalingGraphene research and applicationsProtein Structure and DynamicsCancer, Hypoxia, and MetabolismEnzyme Structure and Function

Les publications récentes

Accès ouvert 2026 supplementary-materials OpenAlex

Supplementary Figure S2 from Discovery of BBO-11818, a Potent and Selective Noncovalent Inhibitor of (ON) and (OFF) KRAS with Activity against Multiple Oncogenic Mutants

Carlos E. Stahlhut, Anna E. Maciag, Kyle A. Sullivan, Kanchan Singh et autres

Supplementary Figure S2 shows the sensorgrams curves used to calculate the binding kinetics of BBO-11818 to four KRAS variants and wild-type HRAS and NRAS in their GDP- or GppNHp-bound forms in a Surface Plasmon Resonance (SPR) assay.

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Accès ouvert 2026 supplementary-materials OpenAlex

Supplementary Figure S5 from Discovery of BBO-11818, a Potent and Selective Noncovalent Inhibitor of (ON) and (OFF) KRAS with Activity against Multiple Oncogenic Mutants

Carlos E. Stahlhut, Anna E. Maciag, Kyle A. Sullivan, Kanchan Singh et autres

Supplementary Figure S5 shows pAKT inhibition by BBO-11818 over a time course experiment in a KRASG12V cell line.

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Accès ouvert 2026 supplementary-materials OpenAlex

Supplementary Figure S1 from Discovery of BBO-8520, a First-In-Class Direct and Covalent Dual Inhibitor of GTP-Bound (ON) and GDP-Bound (OFF) KRASG12C

Anna E. Maciag, James P. Stice, Bin Wang, Alok Kumar Sharma et autres

Supplementary Figure S1 shows the Kinact/KI values for BBO-8520, sotorasib and adagrasib in biochemical and cell-based assays

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Accès ouvert 2026 supplementary-materials OpenAlex

Supplementary Figure S3 from Discovery of BBO-11818, a Potent and Selective Noncovalent Inhibitor of (ON) and (OFF) KRAS with Activity against Multiple Oncogenic Mutants

Carlos E. Stahlhut, Anna E. Maciag, Kyle A. Sullivan, Kanchan Singh et autres

Supplementary Figure S3 shows the binding of BBO-11818 bound to KRASG12D and HRASG12D/Q95H, detailing key interactions in the binding pocket through electron density contours and crystal structure models.

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Accès ouvert 2026 supplementary-materials OpenAlex

Supplementary Figure S5 from Discovery of BBO-8520, a First-In-Class Direct and Covalent Dual Inhibitor of GTP-Bound (ON) and GDP-Bound (OFF) KRASG12C

Anna E. Maciag, James P. Stice, Bin Wang, Alok Kumar Sharma et autres

Supplementary Figure S5 shows that BBO-8520 demonstrates in vivo pERK inhibition, KRAS G12C target engagement and is well tolerated

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Accès ouvert 2026 other OpenAlex

Suppl. Materials and Methods 1 from Discovery of BBO-11818, a Potent and Selective Noncovalent Inhibitor of (ON) and (OFF) KRAS with Activity against Multiple Oncogenic Mutants

Carlos E. Stahlhut, Anna E. Maciag, Kyle A. Sullivan, Kanchan Singh et autres

This file contains the supplementary materials and methods for the manuscript.

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Accès ouvert 2026 supplementary-materials OpenAlex

Supplementary Figure S7 from Discovery of BBO-11818, a Potent and Selective Noncovalent Inhibitor of (ON) and (OFF) KRAS with Activity against Multiple Oncogenic Mutants

Carlos E. Stahlhut, Anna E. Maciag, Kyle A. Sullivan, Kanchan Singh et autres

Supplementary Figure S7 shows the dose- and time-dependent inhibition of DUSP6 and pERK in KRAS-mutant CDX models treated with BBO-11818, as well as the mean body weight in a KRASG12D CDX model treated with BBO-11818.

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Accès ouvert 2026 supplementary-materials OpenAlex

Supplementary Table S2 from Discovery of BBO-11818, a Potent and Selective Noncovalent Inhibitor of (ON) and (OFF) KRAS with Activity against Multiple Oncogenic Mutants

Carlos E. Stahlhut, Anna E. Maciag, Kyle A. Sullivan, Kanchan Singh et autres

Supplementary Table S2 shows individual EC50 data for the inhibition of ERK phosphorylation in a panel of KRAS-mutant cell lines treated with BBO-11818.

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Accès ouvert 2026 supplementary-materials OpenAlex

Supplementary Figure S4 from Discovery of BBO-8520, a First-In-Class Direct and Covalent Dual Inhibitor of GTP-Bound (ON) and GDP-Bound (OFF) KRASG12C

Anna E. Maciag, James P. Stice, Bin Wang, Alok Kumar Sharma et autres

Supplementary Figure S4 summarizes cysteine profiling, RNA-seq and kinomescan studies demonstrating that BBO-8520 is selective for KRAS G12C and MAPK inhibition.

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Accès ouvert 2026 supplementary-materials OpenAlex

Supplementary Figure S1 from Discovery of BBO-11818, a Potent and Selective Noncovalent Inhibitor of (ON) and (OFF) KRAS with Activity against Multiple Oncogenic Mutants

Carlos E. Stahlhut, Anna E. Maciag, Kyle A. Sullivan, Kanchan Singh et autres

Supplementary Figure S1 shows the sensorgrams curves used to calculate the binding kinetics of Compound 2 to three KRAS variants in their GDP- or GppNHp-bound forms in a Surface Plasmon Resonance (SPR) assay.

0 citations

Accès ouvert 2026 supplementary-materials OpenAlex

Supplementary Figure S6 from Discovery of BBO-8520, a First-In-Class Direct and Covalent Dual Inhibitor of GTP-Bound (ON) and GDP-Bound (OFF) KRASG12C

Anna E. Maciag, James P. Stice, Bin Wang, Alok Kumar Sharma et autres

Supplementary Figure S6 shows that BBO-8520 shows anti-tumor activity in NCI-H358 CDX sotorasib-resistant tumors

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Accès ouvert 2026 supplementary-materials OpenAlex

Supplementary Figure S4 from Discovery of BBO-11818, a Potent and Selective Noncovalent Inhibitor of (ON) and (OFF) KRAS with Activity against Multiple Oncogenic Mutants

Carlos E. Stahlhut, Anna E. Maciag, Kyle A. Sullivan, Kanchan Singh et autres

Supplementary Figure S4 shows the binding differences of BBO-11818 and BBO-8520 to KRASG12D and KRASG12C, respectively, in the GDP- or GppNHp-bound states, in a crystal structure model. Additionally, it shows in silico predicted interactions of BBO-11818 to different KRAS variants, based on …

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