Andrew B. Sharabi

CD47 blockade (ALX301) enhances immunoradiotherapy response in HPV negative head and neck squamous cell carcinoma

Abdula Monther, Riyam Al-Msari, Robert Saddawi-Konefka, Santiago Fassardi et autres

Head and neck squamous cell carcinoma (HNSCC) is a significant cause of morbidity and mortality worldwide, with limited treatment options for patients with locally advanced disease. CD47 immune checkpoint inhibitors have been used to block the CD47/SIRPa interaction that inhibits antigen-presenting cell …

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Spontaneous cSCC Murine Model Shows Limited Response to PD-1 Blockade and Radiation Combination Therapy

Tara M. Hosseini, Lap Ho, Tammy B. Pham, A Molinolo et autres

Background/Objectives: Non-melanoma skin cancer, which includes cutaneous squamous cell carcinoma (cSCC), ranks as the 5th most common cancer globally with high morbidity and more total deaths than melanoma despite having a lower mortality rate. While most cSCC cases can be treated with …

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676 Lymphatic-sparing immunoradiotherapy reprograms migratory dendritic cells to drive tumor rejection via the sentinel lymph node

Robert Saddawi‐Konefka, Riyam Al Msari, Shiqi Tang, Sayed Sadat et autres

Background The phase III trial KEYNOTE-689 has now established a new standard of care in resectable, locally advanced head and neck squamous cell carcinoma by integrating perioperative PD-1 blockade with surgery and (chemo)radiation. In contrast, four recent phase III trials adding concurrent …

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Supplementary Table 1 from HPV E5 Mediates Resistance to Chemotherapy and Radiation by Promoting a Stem Cell–Like Phenotype in Head and Neck Squamous Cell Carcinoma

Roy S, Sayuri Miyauchi, Riley N. Jones, Sangwoo S. Kim et autres

List of primer sequences

Supplementary Figure 1 from HPV E5 Mediates Resistance to Chemotherapy and Radiation by Promoting a Stem Cell–Like Phenotype in Head and Neck Squamous Cell Carcinoma

Roy S, Sayuri Miyauchi, Riley N. Jones, Sangwoo S. Kim et autres

Expression of HPV E5, E6 and E7 in different HNSCC cells and normal keratinocytes (HaCaT)

Data from HPV E5 Mediates Resistance to Chemotherapy and Radiation by Promoting a Stem Cell–Like Phenotype in Head and Neck Squamous Cell Carcinoma

Roy S, Sayuri Miyauchi, Riley N. Jones, Sangwoo S. Kim et autres

Abstract Human papillomavirus (HPV)–associated head and neck squamous cell carcinoma (HPV+ HNSCC) is one of the most rapidly increasing cancers in the United States. Although patients with HPV+ HNSCC exhibit better responses to chemoradiation compared with patients with HPV− HNSCC, a subset …

Supplementary Figure 4 from HPV E5 Mediates Resistance to Chemotherapy and Radiation by Promoting a Stem Cell–Like Phenotype in Head and Neck Squamous Cell Carcinoma

Roy S, Sayuri Miyauchi, Riley N. Jones, Sangwoo S. Kim et autres

shRNA mediated knockdown of SOX9 in HNSCC cells, measurement of apoptosis and DNA damage response in SOX9 silenced EV HNSCC cells

Supplementary Figure 5 from HPV E5 Mediates Resistance to Chemotherapy and Radiation by Promoting a Stem Cell–Like Phenotype in Head and Neck Squamous Cell Carcinoma

Roy S, Sayuri Miyauchi, Riley N. Jones, Sangwoo S. Kim et autres

Prognosis of HNSCC patients based on the status of E5 signature and expression distribution of E5 in single cell RNA-sequencing dataset

Supplementary Figure 2 from HPV E5 Mediates Resistance to Chemotherapy and Radiation by Promoting a Stem Cell–Like Phenotype in Head and Neck Squamous Cell Carcinoma

Roy S, Sayuri Miyauchi, Riley N. Jones, Sangwoo S. Kim et autres

Measurement of apoptosis after knockdown of E5 in HNSCC cells and evaluation of DNA damage response in E5 expressed and E5 knockdown HNSCC cells

Supplementary Figure 3 from HPV E5 Mediates Resistance to Chemotherapy and Radiation by Promoting a Stem Cell–Like Phenotype in Head and Neck Squamous Cell Carcinoma

Roy S, Sayuri Miyauchi, Riley N. Jones, Sangwoo S. Kim et autres

Differential gene expression and pathway analysis

Assessing dosimetric benefit from daily online adaptive radiation therapy for esophageal cancer

Michael Vincent Sherer, Ayaka Owaga, Andrew B. Sharabi, Xenia J. Ray

A cohort of 19 esophageal cancer patients treated at our institution were analyzed to assess the clinical feasibility and dosimetric benefit from daily adaptive radiation therapy (ART). An Ethos-planning template was developed to generate the initial ethos reference plan and daily adaptive …

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HPV E5 Mediates Resistance to Chemotherapy and Radiation by Promoting a Stem Cell–Like Phenotype in Head and Neck Squamous Cell Carcinoma

Roy S, Sayuri Miyauchi, Riley N. Jones, Sangwoo S. Kim et autres

Human papillomavirus (HPV)-associated head and neck squamous cell carcinoma (HPV+ HNSCC) is one of the most rapidly increasing cancers in the United States. Although patients with HPV+ HNSCC exhibit better responses to chemoradiation compared with patients with HPV- HNSCC, a subset still …

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