Javier Menéndez-Menéndez

Melatonin Modulation of Radiation-Induced Molecular Changes in MCF-7 Human Breast Cancer Cells

Carolina Alonso‐González, Cristina González-Abalde, Javier Menéndez-Menéndez, Alicia González-González et autres

Radiation therapy is an important component of cancer treatment scheduled for cancer patients, although it can cause numerous deleterious effects. The use of adjuvant molecules aims to limit the damage in normal surrounding tissues and enhance the effects of radiation therapy, either …

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Melatonin as an Adjuvant to Antiangiogenic Cancer Treatments

Alicia González, Carolina Alonso‐González, Alicia González-González, Javier Menéndez-Menéndez et autres

Melatonin is a hormone with different functions, antitumor actions being one of the most studied. Among its antitumor mechanisms is its ability to inhibit angiogenesis. Melatonin shows antiangiogenic effects in several types of tumors. Combination of melatonin and chemotherapeutic agents have a …

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Melatonin as a Radio-Sensitizer in Cancer

Carolina Alonso‐González, Alicia González, Javier Menéndez-Menéndez, Carlos Martínez‐Campa et autres

Radiotherapy is one of the treatments of choice in many types of cancer. Adjuvant treatments to radiotherapy try, on one hand, to enhance the response of tumor cells to radiation and, on the other hand, to reduce the side effects to normal …

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Usefulness of melatonin as complementary to chemotherapeutic agents at different stages of the angiogenic process

Alicia González-González, Alicia González, Noemı́ Rueda, Carolina Alonso‐González et autres

Chemotherapeutics are sometimes administered with drugs, like antiangiogenic compounds, to increase their effectiveness. Melatonin exerts antitumoral actions through antiangiogenic actions. We studied if melatonin regulates the response of HUVECs to chemotherapeutics (docetaxel and vinorelbine). The inhibition that these agents exert on some …

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Melatonin Modulation of Radiation and Chemotherapeutics-induced Changes on Differentiation of Breast Fibroblasts

Alicia González-González, Enrique García Nieto, Alicia González, Cristina Sánchez–Fernández et autres

Melatonin exerts oncostatic actions and sensitizes tumor cells to chemotherapeutics or radiation. In our study, we investigated the effects of docetaxel, vinorelbine, and radiation on human breast fibroblasts and its modulation by melatonin. Docetaxel or vinorelbine inhibits proliferation and stimulates the differentiation …

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Deciphering the Molecular Basis of Melatonin Protective Effects on Breast Cells Treated with Doxorubicin: TWIST1 a Transcription Factor Involved in EMT and Metastasis, a Novel Target of Melatonin

Javier Menéndez-Menéndez, Francisco Hermida‐Prado, Rocío Granda‐Díaz, Alicia González et autres

Melatonin mitigates cancer initiation, progression and metastasis through inhibition of both the synthesis of estrogens and the transcriptional activity of the estradiol-ER (Estrogen receptor) complex in the estrogen-dependent breast cancer cell line MCF-7. Moreover, melatonin improves the sensitivity of MCF-7 to chemotherapeutic …

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Melatonin Enhances the Usefulness of Ionizing Radiation: Involving the Regulation of Different Steps of the Angiogenic Process

Alicia González-González, Alicia González, Noemı́ Rueda, Carolina Alonso‐González et autres

Radiotherapy is a part of cancer treatment. To improve its efficacy has been combined with radiosensitizers such as antiangiogenic agents. Among the mechanisms of the antitumor action of melatonin are antiangiogenic effects. Our goal was to investigate whether melatonin may modulate the …

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Melatonin: An Anti-Tumor Agent in Hormone-Dependent Cancers

Javier Menéndez-Menéndez, Carlos Martínez‐Campa

Melatonin (N-acetyl-5-methoxytryptamine) is a hormone synthesized and secreted by the pineal gland mainly during the night, since light exposure suppresses its production. Initially, an implication of this indoleamine in malignant disease was described in endocrine-responsive breast cancer. Data from several clinical trials …

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Melatonin inhibits angiogenesis in SH-SY5Y human neuroblastoma cells by downregulation of VEGF

Alicia González, Alicia González-González, Carolina Alonso‐González, Javier Menéndez-Menéndez et autres

Vascular endothelial growth factor (VEGF) produced from tumor cells plays a crucial role in the pathogenesis and neovascularization of neuroblastoma. Inhibition of VEGF secretion by tumor cells, as well as VEGF-regulated signaling in endothelial cells, are important to reduce the angiogenesis and …

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What is known about melatonin, chemotherapy and altered gene expression in breast cancer

Carlos Martínez‐Campa, Javier Menéndez-Menéndez, Carolina Alonso‐González, Alicia González et autres

studies to have an oncostatic role in hormone-dependent tumors. Furthermore, several clinical trials point to melatonin as a promising adjuvant molecule to be considered for cancer treatment. In the past few years, evidence of a broader spectrum of action of melatonin as …

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Sensitizing effects of melatonin on docetaxel treatment in MCF-7 breast cancer cells

Javier Menéndez-Menéndez

Melatonin enhancement of the radiosensitivity of human breast cancer cells is associated with the modulation of proteins involved in estrogen biosynthesis

Carolina Alonso‐González, Alicia González, Carlos Martínez‐Campa, Javier Menéndez-Menéndez et autres

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