Elodie Ly

Automation of an algorithm based on fuzzy clustering for analyzing tumoral heterogeneity in human skin carcinoma tissue sections

David Sebiskveradze, Valériu Vrabie, Cyril Gobinet, A. Durlach et autres

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Histopathological characterization of primary cutaneous melanoma using infrared microimaging: a proof-of-concept study

Elodie Ly, Nathalie Cardot‐Leccia, J.‐P. Ortonne, Maxime Benchetrit et autres

BACKGROUND: The diagnosis of malignant melanoma is based upon the histological evaluation of the lesion. As such, the morphological interpretation relies on the expertise of a dermatopathologist. Infrared microimaging is emerging as a new powerful tool to investigate tissue biochemistry. Infrared spectra …

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Probing Tumour and Peritumoral Tissues in Superficial and Nodular Skin Basal Cell Carcinoma Using Polarized Raman Microspectroscopy

Elodie Ly, A. Durlach, Frank Antonicelli, Philippe Bernard et autres

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation E. Ly, A. Durlach, F. Antonicelli, P. Bernard, M. …

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Probing tumor and peritumoral tissues in superficial and nodular basal cell carcinoma using polarized Raman microspectroscopy

Elodie Ly, A. Durlach, Frank Antonicelli, Philippe Bernard et autres

Basal cell carcinoma (BCC) can sometimes lead, through a possible invasion of the dermis and the subcutaneous tissue, to serious local damage to the patient. Several histological types of BCC are reported, among them, the superficial, nodular and infiltrative forms. This study …

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From preprocessing to fuzzy classification of IR images of paraffin embedded cancerous skin samples

David Sebiskveradze, Elodie Ly, Cyril Gobinet, Olivier Piot et autres

Mid-infrared (IR) micro-spectral imaging is an efficient method to analyze molecular composition of biomedical samples. In clinical oncology, this non-invasive technique is generally used on frozen biopsies to localize and diagnose cancerous tissues in their early stages. However, samples are usually fixed …

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Abstract #4314: Development of an infrared-imaging-based histology for the differential diagnosis of non-melanoma skin cancers

Elodie Ly, Olivier Piot, A. Durlach, Philippe Bernard et autres

Skin cancer is one of the most common types of cancer in the light-skinned population. Non-melanoma skin cancers (NMSC) are the most frequent, more than one million cases occur annually in the United States 1 . They include basal cell carcinoma (BCC) …

Differential diagnosis of cutaneous carcinomas by infrared spectral micro-imaging combined with pattern recognition

Elodie Ly, Olivier Piot, Anne Durlach, Philippe Bernard et autres

Non-melanoma skin cancer includes basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and Bowen's disease. The differential diagnosis of these lesions is sometimes difficult and relies on the histopathological examination of surgical specimens. However, a precise differential diagnosis is crucial for an …

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Caractérisations des lésions cutanées par microspectroscopies optiques vibrationnelles : applications ex vivo et in vivo

Elodie Ly

La @peau est notre organe le plus important de par sa surface et son poids. Veritable barriere aux agressions exterieures, elle represente notre premiere ligne de defense naturelle. C'est un organe complexe qui presente une forte heterogeneite, et qui peut etre altere …

IR Spectral Imaging for Histopathological Characterization of Xenografted Human Colon Carcinomas

Rob W F Wolthuis, Adrian Travo, Céline Nicolet, Agnès Neuville et autres

This study aims to develop IR imaging of tumor tissues for generating an automated IR-based histology. Formalin-fixed paraffin-embedded xenografts of human colon carcinomas were analyzed. Chemometric and statistical multivariate treatments of spectral data permitted to probe the intrinsic chemical composition of tissues, …

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Effects of digital dewaxing methods on K-means-clusterized IR images collected on formalin-fixed paraffin-embedded samples of skin carcinoma

David Sebiskveradze, Cyril Gobinet, Elodie Ly, Michel Manfait et autres

Mid-IR spectral imaging is an efficient method to analyze biological samples. Several research studies showed its potential to diagnose cancerous tissues. However, some limitations appear when formalin-fixed paraffin-embedded tissues are studied due to the intense IR contribution of paraffin, unless to perform …

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Combination of FTIRspectral imaging and chemometrics for tumour detection from paraffin-embedded biopsies

Elodie Ly, Olivier Piot, Rolf Wolthuis, A. Durlach et autres

FTIR spectral imaging was applied on formalin-fixed paraffin-embedded biopsies from colon and skin cancerous lesions. These samples were deposited onto different substrates (zinc selenide and calcium fluoride respectively) and embedded using two types of paraffin. Formalin fixation followed by paraffin embedding is …

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The TIGR Plant Transcript Assemblies database

Kevin L. Childs, John P. Hamilton, W. Zhu, Elodie Ly et autres

The TIGR Plant Transcript Assemblies (TA) database (http://plantta.tigr.org) uses expressed sequences collected from the NCBI GenBank Nucleotide database for the construction of transcript assemblies. The sequences collected include expressed sequence tags (ESTs) and full-length and partial cDNAs, but exclude computationally predicted gene …