Brian J. Anderson

Response: Codeine in Breast Milk: Minimal Transfer, Still Risky for Neonates

Brian J. Anderson, Jacqueline A. Hannam

nz (code pays fourni par la source)

Milk Fasting Times and Aspiration in Infants

Richard Newton, Thomas Engelhardt, Brian J. Anderson

Thomas Engelhardt sits on the Editorial Board of the journal Pediatric Anesthesia. The authors have no other conflicts of interest to declare. Data sharing not applicable to this article as no datasets were generated or analysed during the current study.

gb, ca, nz (code pays fourni par la source)

Dabigatran-idarucizumab pharmacokinetics-pharmacodynamics in sheep undergoing cardiopulmonary bypass

Michael P. Eaton, Sergiy M. Nadtochiy, Tatsiana Stefanos, Brian J. Anderson

Background The effect of the anticoagulant, dabigatran, and its antagonist, idarucizumab, on coagulation remains poorly quantified. There are few pharmacokinetic-pharmacodynamic data available to describe the interaction in humans or animals undergoing cardiopulmonary bypass. Methods Six sheep were given intravenous dabigatran infusion while …

us, nz (code pays fourni par la source)

Pharmacokinetic and Pharmacodynamic Modeling of Clonidine and Midazolam for Sedation in Pediatric Intensive Care

Maddlie Bardol, Yucheng Sheng, Manuel A. Baarslag, Adriana Ceci et autres

BACKGROUND: Clonidine and midazolam are routinely used in the pediatric intensive care unit for pain and sedation management, but target concentration and optimal dose are poorly defined for both drugs. The CloSed study is a multicenter, double-blind, randomized, active-controlled noninferiority trial with …

gb, de, nl, it, ee, se, cz, nz (code pays fourni par la source)

Propofol: A Medication That Changed Pediatric Anesthesia Practice

Brian J. Anderson, Luis Ignacio Cortínez

The introduction of propofol changed our understanding of pediatric anesthesia pharmacology, research approaches for intravenous drug study, and led to infusion pump development for the maintenance phase of anesthesia. The story of propofol development provides a blueprint for other intravenous drug development. …

nz, cl (code pays fourni par la source)

Intravenous Dabigatran for Anticoagulation during Cardiopulmonary Bypass in a Sheep Model

Sergiy M. Nadtochiy, Tatsiana Stefanos, Ronald E. Angona, Nathan Darrow et autres

BACKGROUND: Heparin is the standard anticoagulant used during cardiopulmonary bypass (CPB). However, there are problems with heparin, including immunogenicity and variability of effect, that make a search for an alternative desirable. Dabigatran anticoagulation has been reported to provide adequate conditions for CPB …

us, nz (code pays fourni par la source)

Pharmacokinetics of Intraperitoneal Lidocaine for Sustained Postoperative Analgesia in Adults

Kent C. Osborne, Wiremu MacFater, Brian J. Anderson, Darren Svirskis et autres

Background and Objective Intraperitoneal lidocaine is an emerging strategy for analgesia following abdominal surgery but its pharmacokinetics are poorly quantified. We aimed to develop a pharmacokinetic model for unbound and total lidocaine by intraperitoneal and intravenous routes. Methods Unbound and total lidocaine …

nz (code pays fourni par la source)

Evaluation of the response to antibiotic treatment in newly placed finishing pigs

Brian J. Anderson, John Hall

Pharmacokinetic and Physiological Concepts Relevant for Determining Sevoflurane Dose

James D. Morse, Brian J. Anderson

Brian Anderson sits on the Editorial Board of the journal Pediatric Anesthesia. Data sharing not applicable to this article as no datasets were generated or analyzed during the current study. File S1 Please note: The publisher is not responsible for the content …

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Mucositis Pain and Its Temporal Relationship to White Cell Count

Claire Douglas, James D. Morse, Brian J. Anderson

ABSTRACT Background Children who have received chemotherapy and/or radiotherapy treatment resulting in neutropenia can suffer painful mucositis. We explored the relationship between pain score and white cell count in children with mucositis due to immunosuppression and assessed the influence of opioid and …

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Improving the Safety of Pediatric Sedation: Human Expertise, Technology, and System Redesign

Craig S. Webster, Brian J. Anderson, Michael J. Stabile, Simon J Mitchell et autres

nz, us, au (code pays fourni par la source)

Pharmacokinetics and Pharmacodynamics in the Pediatric Population

Brian J. Anderson

nz (code pays fourni par la source)