Yoshinobu Shigekawa

SMYD2 regulates lymph node metastasis derived from intrahepatic cholangiocellular carcinoma through CCR7-dependent chemotaxis

Masashi Nakamura, Shinya Hayami, Atsushi Miyamoto, Norihiko Suzaki et autres

Abstract Intrahepatic cholangiocellular carcinoma (ICC) has poor prognosis, especially with lymph node (LN) metastasis (LNM). Lysine methyltransferase SET and MYND domain-containing 2 (SMYD2) has critical roles and is reportedly associated with poor prognosis in various cancers, but the role of SMYD2 in …

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Impact of SETD8/KMT5A overexpression on hepatocellular carcinoma progression and prognosis

Norihiko Suzaki, Shinya Hayami, Atsushi Miyamoto, Masashi Nakamura et autres

BACKGROUND: Hepatocellular carcinoma has poor prognosis due to its high recurrence rate, even after curative surgery. Epigenetic regulators are known to play a critical role in cancer progression, and the histone methyltransferase SETD8/KMT5A has been reported to be overexpressed in various malignancies. …

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Robot-Assisted Spleen-Preserving Distal Pancreatectomy for an Epithelial Cyst Arising from an Intrapancreatic Accessory Spleen: A Case Report

Masaki Ueno, Fumitoshi Hirokawa, Yoshinobu Shigekawa, Masamichi Kimura et autres

INTRODUCTION: Epithelial cysts arising from an intrapancreatic accessory spleen (ECIPAS) are rare and often misdiagnosed as pancreatic cystic neoplasms because their imaging features frequently overlap. When malignancy cannot be ruled out, surgical resection is generally indicated, and minimally invasive approaches have become …

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Sclerosing angiomatoid nodular transformation of the spleen with thrombocytopenia

H. Kuroiwa, Masaki Ueno, Fumitoshi Hirokawa, Yoshinobu Shigekawa et autres

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Histone methyltransferase SUV420H1 / KMT5B contributes to poor prognosis in hepatocellular carcinoma

Hirotaka Kato, Shinya Hayami, Masaki Ueno, Norihiko Suzaki et autres

Hepatocellular carcinoma (HCC) has a high rate of recurrence and poor prognosis, even after curative surgery. Multikinase inhibitors have been applied for HCC patients, but their effect has been restricted. This study aims to clarify the clinical impact of SUV420H1/KMT5B, one of …

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Impact Of The COVID-19 Pandemic on Time To Treatment Initiation For Colorectal Cancer In Japan

Koichi Tamura, Satoru Ozawa, Fumitoshi Hirokawa, Yoshinobu Shigekawa et autres

Abstract Purpose This retrospective study aims to evaluate potential differences of diagnosis and treatment of colorectal cancer between the two years before and after the onset of the COVID-19 pandemic. Methods Retrospectively enrolled in this study were consecutive patients with colorectal cancer …

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Ground improvement of foundation ground of coal storage facility by INSEM method.

Kei Sato, Yoshinobu Shigekawa, Akihiko Ogata, Yoshinori Nishiuchi et autres

A consideration of temperature conditions on temperature stress analytical approach for fly ash concrete

Chiharu Mikuni, Hitoshi Gotou, Yoshinori Nishiuchi, Akihiko Ogata et autres

Overexpression of KDM5B/JARID1B is associated with poor prognosis in hepatocellular carcinoma

Yoshinobu Shigekawa, Shinya Hayami, Masaki Ueno, Atsushi Miyamoto et autres

// Yoshinobu Shigekawa 1 , Shinya Hayami 1 , Masaki Ueno 1 , Atsushi Miyamoto 1 , Norihiko Suzaki 1 , Manabu Kawai 1 , Seiko Hirono 1 , Ken-ichi Okada 1 , Ryuji Hamamoto 2 and Hiroki Yamaue 1 1 Second …

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Depth of Hepatic Infiltration and Lymph Node Swelling as Factors for Considering Surgery for T2-4 Gallbladder Carcinoma Patients.

Ken‐ichi Okada, Manabu Kawai, Masaki Ueno, Seiko Hirono et autres

BACKGROUND/AIM: The aim of the present study was to clarify if the degree of hepatic infiltration and lymph node swelling of gallbladder carcinoma (GBC) should be held as deciding factors for T2-4 GBC patients to undergo surgery. PATIENTS AND METHODS: Fifty consecutive …

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The characteristics of pancreatic neck cancer.

Hiroki Yamaue, Seiko Hirono, Manabu Kawai, Ken‐ichi Okada et autres

337 Background: Pancreatic neck cancer occurs in the small region surrounded by the common hepatic artery (CHA), gastroduodenal artery (GDA), and portal vein (PV). The specific clinicopathological characteristics of pancreatic neck cancer remain unclear. This study aimed to identify specific biological behaviors …

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Prognostic impact of surgery and radiofrequency ablation on single nodular HCC ⩽5 cm: Cohort study based on serum HCC markers

Masaki Ueno, Shinya Hayami, Yoshinobu Shigekawa, Manabu Kawai et autres

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