Wan Chen Lin

Nucleus accumbens dopamine release reflects Bayesian inference during instrumental learning

Albert J. Qü, Lung-Hao Tai, Christopher D. Hall, Emilie M Tu et autres

Dopamine release in the nucleus accumbens has been hypothesized to signal the difference between observed and predicted reward, known as reward prediction error, suggesting a biological implementation for reinforcement learning. Rigorous tests of this hypothesis require assumptions about how the brain maps …

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Transient, persistent and permanent left bundle branch block?

Wan Chen Lin, Min Yu

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Genetic changes linked to two different syndromic forms of autism enhance reinforcement learning in early adolescent male but not female mice

Juliana Chase, Jing‐Jing Li, Wan Chen Lin, Lung-Hao Tai et autres

Abstract Autism Spectrum Disorder (ASD) is characterized by restricted and repetitive behaviors and social differences, both of which may manifest, in part, from underlying differences in corticostriatal circuits and reinforcement learning. Here, we investigated reinforcement learning in developing mice with mutations in …

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Association Between the INR and Warfarin Dose in Patients With Mechanical Prosthetic Heart Valves

Jing Cao, Shan Zou, Xiaoqing Dai, Wan Chen Lin et autres

Background Although several algorithms have been proposed to predict individual warfarin doses, the relationships between the international normalized ratio (INR) and cumulative warfarin dose remain to be determined. Objectives The aim of this study was to explore the correlation between the INR …

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Adolescent and adult mice use both incremental reinforcement learning and short term memory when learning concurrent stimulus-action associations

Juliana Chase, Liyu Xia, Lung-Hao Tai, Wan Chen Lin et autres

Computational modeling has revealed that human research participants use both rapid working memory (WM) and incremental reinforcement learning (RL) (RL+WM) to solve a simple instrumental learning task, relying on WM when the number of stimuli is small and supplementing with RL when …

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Adolescent and adult mice use both incremental reinforcement learning and short term memory when learning concurrent stimulus-action associations

Juliana Chase, Liyu Xia, Lung-Hao Tai, Wan Chen Lin et autres

Abstract Computational modeling has revealed that human research participants use both rapid working memory (WM) and incremental reinforcement learning (RL) (RL+WM) to solve a simple instrumental learning task, relying on WM when the number of stimuli is small and supplementing with RL …

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Experimental biology can inform our understanding of food insecurity

Linda Wilbrecht, Wan Chen Lin, Kathryn Callahan, Melissa Bateson et autres

Food insecurity is a major public health issue. Millions of households worldwide have intermittent and unpredictable access to food and this experience is associated with greater risk for a host of negative health outcomes. While food insecurity is a contemporary concern, we …

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Nucleus accumbens dopamine release reflects Bayesian inference during instrumental learning

Albert J. Qü, Lung-Hao Tai, Christopher D. Hall, Emilie M Tu et autres

Dopamine release in the nucleus accumbens has been hypothesized to signal reward prediction error, the difference between observed and predicted reward, suggesting a biological implementation for reinforcement learning. Rigorous tests of this hypothesis require assumptions about how the brain maps sensory signals …

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The maturation of exploratory behavior in adolescent Mus spicilegus on two photoperiods

Noah G. Cryns, Wan Chen Lin, Niloofar Motahari, Oliver J. Krentzman et autres

Dispersal from the natal site or familial group is a core milestone of adolescent development in many species. A wild species of mouse,Mus spicilegus, presents an exciting model in which to study adolescent development and dispersal because it shows different life history …

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Transient food insecurity during the juvenile-adolescent period affects adult weight, cognitive flexibility, and dopamine neurobiology

Wan Chen Lin, Christine Liu, Polina Kosillo, Lung-Hao Tai et autres

A major challenge for neuroscience, public health, and evolutionary biology is to understand the effects of scarcity and uncertainty on the developing brain. Currently, a significant fraction of children and adolescents worldwide experience insecure access to food. The goal of our work …

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Activation, but not inhibition, of the indirect pathway disrupts choice rejection in a freely moving, multiple-choice foraging task

Kristen Delevich, Benjamin Hoshal, Lexi Z. Zhou, Yuting Zhang et autres

The dorsomedial striatum (DMS) plays a key role in action selection, but less is known about how direct and indirect pathway spiny projection neurons (dSPNs and iSPNs, respectively) contribute to choice rejection in freely moving animals. Here, we use pathway-specific chemogenetic manipulation …

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Making sense of strengths and weaknesses observed in adolescent laboratory rodents

Wan Chen Lin, Linda Wilbrecht

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