Paul P. Y. Lu

Dosing parameters for grafting human neural stem cells into sites of spinal cord injury

J. H. Brock, Carly Shevinsky, Lori Graham, Ekkehart Staufenberg et autres

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A facilitatory role of astrocytes in axonal regeneration after acute and chronic spinal cord injury

Paul P. Y. Lu, Lori Graham, Amanda N. Tran, Ashley Villarta et autres

Neuroscience dogma avers that astrocytic "scars" inhibit axonal regeneration after spinal cord injury (SCI). A recent report suggested however that astrocytes form "borders" around lesions that are permissive rather than inhibitory to axonal growth. We now provide further evidence supporting a facilitatory …

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An improved method for generating human spinal cord neural stem cells

Yudian Li, Hiroshige KUMAMARU, Tamara Vokes, Anh Nhat Tran et autres

Neural stem cells have exhibited efficacy in pre-clinical models of spinal cord injury (SCI) and are on a translational path to human testing. We recently reported that neural stem cells must be driven to a spinal cord fate to optimize host axonal …

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Combining neural progenitor cell transplant and rehabilitation for enhanced recovery after cervical spinal cord injury

Camila Marques Freria, Paul P. Y. Lu

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The Chronic Glial Border Does Not Inhibit Axonal Regeneration After Spinal Cord Injury

Paul P. Y. Lu, Lori Graham, Amanda N. Tran, Ashley Villarta et autres

Abstract Neuroscience dogma avers that astrocytic “scars” inhibit axonal regeneration after spinal cord injury (SCI). A recent report suggested however that astrocytes form “borders” around lesions that are not inhibitory and may be permissive to axonal growth, although direct evidence is lacking. …

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Adaptation of a cervical bilateral contusive spinal cord injury for study of skilled forelimb function

Camila Marques Freria, Lori Graham, Ali Azimi, Paul P. Y. Lu

We present an updated, clinically relevant model of moderately severe bilateral cervical level 6 contusive spinal cord injury (SCI) in the rat. This model is more clinically relevant than previous models due it its severity, yet animals readily survive the lesion. The …

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BDNF guides neural stem cell-derived axons to ventral interneurons and motor neurons after spinal cord injury

Yuanyuan Li, Amanda N. Tran, Lori Graham, J. H. Brock et autres

Neural stem cells (NSCs) implanted into sites of spinal cord injury (SCI) extend very large numbers of new axons over very long distances caudal to the lesion site, and support partial functional recovery. Newly extending graft axons distribute throughout host gray and …

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Rehabilitation combined with neural progenitor cell grafts enables functional recovery in chronic spinal cord injury

Paul P. Y. Lu, Camila Marques Freria, Lori Graham, Amanda N. Tran et autres

We reported previously that neural progenitor cell (NPC) grafts form neural relays across sites of subacute spinal cord injury (SCI) and support functional recovery. Here, we examine whether NPC grafts after chronic delays also support recovery and whether intensive rehabilitation further enhances …

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Corticospinal tract regeneration after spinal cord injury: Implications for treatment and recovery

Yuanyuan Li, Paul P. Y. Lu

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Motor neuron replacement therapy for amyotrophic lateral sclerosis

Lingyan Zhang, Zhiguo Chen, Paul P. Y. Lu, Bochao Liu et autres

Amyotrophic lateral sclerosis is a motor neuron degenerative disease that is also known as Lou Gehrig's disease in the United States, Charcot's disease in France, and motor neuron disease in the UK. The loss of motor neurons causes muscle wasting, paralysis, and …

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Neural Stem Cells: Promoting Axonal Regeneration and Spinal Cord Connectivity

Camila Marques Freria, Erna van Niekerk, Armin Blesch, Paul P. Y. Lu

Spinal cord injury (SCI) leads to irreversible functional impairment caused by neuronal loss and the disruption of neuronal connections across the injury site. While several experimental strategies have been used to minimize tissue damage and to enhance axonal growth and regeneration, the …

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CRISPR/Cas9 mediated somatic gene therapy for insertional mutations: the vibrator mouse model

Xin Fu, Jie Zhu, Yaou Duan, Paul P. Y. Lu et autres

Abstract Somatic gene therapy remains technically challenging, especially in the central nervous system (CNS). Efficiency of gene delivery, efficacy in recipient cells, and proportion of cells required for overall benefit are the key points needed to be considered in any therapeutic approach. …

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