Georgina Cox

Erratum for Berry et al., “The Staphylococcus aureus esterase FmtA is essential for wall teichoic acid D-alanylation”

Kirsten A. Berry, Mackenzie T. A. Verhoef, Zhiyong Zheng, Ronald S. Flannagan et autres

Volume 16, no. 10, e02337-25, 2025, https://doi.org/10.1128/mbio.02337-25. Introduction, paragraph 4, sentence 3: “the formyl methionyl transferase A (FmtA) enzyme in S. aureus has...” should read “the FmtA enzyme, named for its role as a factor that affects the methicillin resistance level and …

An anti-adhesive compound modulating the production of Staphylococcus aureus cell wall-anchored proteins

Allison C. Leonard, Ruina Bao, Cindy Menjivar, Megan Myers et autres

As one of the leading global causes of death associated with antimicrobial resistance, Staphylococcus aureus frequently colonizes the human nasal cavity and adheres to keratinized skin, establishing reservoirs that drive subsequent infections and emphasize the need for new decolonization strategies. Using a …

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An anti-adhesive compound that modulates the production of Staphylococcus aureus cell wall-anchored proteins

Georgina Cox

An anti-adhesive compound that modulates the production of Staphylococcus aureus cell wall-anchored proteins

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An anti-adhesive compound that modulates the production of Staphylococcus aureus cell wall-anchored proteins

Georgina Cox

An anti-adhesive compound that modulates the production of Staphylococcus aureus cell wall-anchored proteins

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Genetic Tools and Approaches to Study Bacterial Efflux Pumps

Megan R Caswell, Mallory Wright, Georgina Cox

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The Staphylococcus aureus esterase FmtA is essential for wall teichoic acid D-alanylation

Kirsten A. Berry, Mackenzie T. A. Verhoef, Zhiyong Zheng, Ronald S. Flannagan et autres

ABSTRACT Staphylococcus aureus teichoic acids are anionic glycopolymers covalently attached to peptidoglycan (wall teichoic acids, WTAs) or anchored to the phospholipid membrane (lipoteichoic acids, LTAs). The post-synthetic addition of D-alanine (D-Ala) residues to these polymers modulates surface charge and contributes to pathogen …

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A historical perspective on the multifunctional outer membrane channel protein TolC in Escherichia coli

Mandeep Kaur, Laura K. Thompson, Georgina Cox

Since its discovery nearly 60 years ago, TolC has been associated with various cellular functions in Escherichia coli, including the efflux of environmental stressors and virulence factors. It also acts as a receptor for specific bacteriophages and the colicin E1 toxin. This …

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The effects of ultra-selective beta1-antagonism on the metabolic and cytokine profile in septic shock patients receiving noradrenaline: a sub-investigation from the STRESS-L Randomised Study

Kirsty McGee, Md. Anower Hossain, Gavin D. Perkins, Anthony Gordon et autres

PURPOSE: The landiolol and organ failure in patients with septic shock (STRESS-L study) included a pre-planned sub-study to assess the effect of landiolol treatment on inflammatory and metabolomic markers. METHODS: Samples collected from 91 patients randomised to STRESS-L were profiled for immune …

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Methods for investigating functional interplay between efflux pumps in Escherichia coli

Megan R Caswell, Georgina Cox

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The inactivation of tolC sensitizes Escherichia coli to perturbations in lipopolysaccharide transport

Shawna Zhu, Mary Kate Alexander, Telmo O. Paiva, Kenneth Rachwalski et autres

The Escherichia coli outer membrane channel TolC complexes with several inner membrane efflux pumps to export compounds across the cell envelope. All components of these complexes are essential for robust efflux activity, yet E. coli is more sensitive to antimicrobial compounds when …

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Landiolol and Organ Failure in Patients With Septic Shock

Tony Whitehouse, Md. Anower Hossain, Gavin D. Perkins, Anthony Gordon et autres

Importance: Patients with septic shock undergo adrenergic stress, which affects cardiac, immune, inflammatory, and metabolic pathways. β-Blockade may attenuate the adverse effects of catecholamine exposure and has been associated with reduced mortality. Objectives: To assess the efficacy and safety of landiolol in …

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Mechanisms of cardiac collapse at high temperature in a marine teleost (Girella nigrians)

Gail D. Schwieterman, Emily A. Hardison, Georgina Cox, Jacey C. Van Wert et autres

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