Yue Fang

Applying synthetic biology in infectious disease prevention and facing biosecurity challenges

Tian Qi, Yue Fang, Wenqing Liu, Xiao He et autres

Abstract Current threats of infectious diseases are severe, marked by prominent challenges such as emerging and re-emerging infections and antimicrobial resistance. Traditional prevention and control methods face limitations including lengthy development cycles, relatively narrow therapeutic targets and insufficient diagnostic sensitivity. Synthetic biology, …

cn (code pays fourni par la source)

BolMYB122-BolTGG1 module enhances salt stress tolerance via accelerating the hydrolysis of glucosinolates to produce sulforaphane in broccoli

Yi-Xiang Wang, Wenting Sun, Jingting Tao, Yue Fang et autres

Glucosinolates (GSLs), one type of secondary metabolites mainly enriched in cruciferous plants, play important roles in environmental stress responses. However, the function and regulatory mechanism of GSLs in combating salt stress in broccoli are largely unclear. In this study, BolTGG1, a member …

cn (code pays fourni par la source)

Poria cocos polysaccharides as a carbon source promotes the proliferation of Parabacteroides distasonis to ameliorate ulcerative colitis: A mechanistic study based on the secondary bile acid-TGR5 axis

Yue Zhang, Yue Fang, Yan Chen, Quan Chen et autres

cn (code pays fourni par la source)

Water-soluble Poria cocos polysaccharide improves alcoholic liver disease via modulation of gut microbiota-mediated intestinal bile acids-farnesoid X receptor

Jiajing Huang, Luzhe Yu, Chen Zhang, Yue Fang et autres

cn (code pays fourni par la source)

Efficient mitochondrial A-to-G base editors for the generation of mitochondrial disease models

Liang Chen, Mengjia Hong, Changming Luan, Meng Yuan et autres

cn (code pays fourni par la source)

Alcaligenes faecalis induces intestinal T helper-17 cells by enhancing Rorc transcription through E3 ligase Trim21-mediated Fbxw7 degradation

Yingying Shen, Zeyu Ma, H X Wang, Yinghu Chen et autres

cn, us (code pays fourni par la source)

Plasma membrane-associated ARAF condensates fuel RAS-related cancer drug resistance

Wen Li, Xiaoxian Shi, Zhaodi Jiang, Mingyi Li et autres

cn (code pays fourni par la source)

When AI Acquires Data: Strategic Complementarities in M&A

Yue Fang, Yupeng He, Zilong Zhang

cn, sg, hk (code pays fourni par la source)

Engineered mitochondrial A-to-G editors with enhanced efficiency and targeting scope

Liang Chen, Mengjia Hong, Changming Luan, Meng Yuan et autres

Summary Mitochondrial base editing is a powerful technology, but the current A-to-G mitochondrial DNA (mtDNA) base editors are reluctant to achieve high efficiency, which is critical for mtDNA engineering. Through laboratory evolution, TadA-8e variants were discovered with substantially increased activity and expanded …

cn, us (code pays fourni par la source)

Transcription factors MdEIL1 and MdHY5 integrate ethylene and light signaling to promote chlorophyll degradation in mature apple peels

Lixian Li, Sankui Yang, Yue Fang, Zhimeng Wu et autres

Abstract Although it is well established that ethylene and light stimulate the process of chlorophyll degradation in mature apple peels, there is still a need for further exploration of the molecular mechanisms that regulate this process. This study identified MdEIL1 and MdHY5 …

cn (code pays fourni par la source)

Characterization of a valproic acid-sensitive mutant allele of the Golgi GDP-mannose transmembrane transporter Vrg4 in Schizosaccharomyces pombe

Teruaki Takasaki, Minami Yamada, Haruka Ikeda, Yue Fang et autres

will be useful in glycobiology and pharmacology.

jp, cn (code pays fourni par la source)

Identification and characterization of a novel antifungal compound tubeimoside I targeting cell wall

Qiannan Liu, Zhiqi Zhong, Shunxin Zheng, Yunzhuo Chu et autres

ABSTRACT Due to fungal diseases that threaten immunocompromised patients, along with the limited availability of antifungal agents, there is an urgent need for new antifungal compounds to treat fungal infections. Here, we aimed to identify potential antifungal drugs from natural products using …

cn, jp (code pays fourni par la source)