Olivier Naret

Genome-to-genome analysis reveals associations between human and mycobacterial genetic variation in tuberculosis patients from Tanzania

Zhi Ming Xu, Michaela Zwyer, Hellen Hiza, Sarah Schmidiger et autres

The risk and prognosis of tuberculosis (TB) are influenced by a complex interplay between human and bacterial genetic factors. While previous genomic studies have largely examined human and bacterial genomes separately, we adopted an integrated approach to uncover host-pathogen interactions. We leveraged …

ch, Tanzanie (code pays fourni par la source)

Joint host-pathogen genomic analysis identifies hepatitis B virus mutations associated with human NTCP and HLA class I variation

Zhi Ming Xu, Gnimah Eva Gnouamozi, Sina Rüeger, Patrick R. Shea et autres

Evolutionary changes in the hepatitis B virus (HBV) genome could reflect its adaptation to host-induced selective pressure. Leveraging paired human exome and ultra-deep HBV genome-sequencing data from 567 affected individuals with chronic hepatitis B, we comprehensively searched for the signatures of this …

ch, de, us, hk, fr (code pays fourni par la source)

Is competition for cellular resources a driver of complex trait heritability?

Olivier Naret, Yuval B. Simons, Jacques Fellay, Jonathan K. Pritchard

Abstract Most human complex traits are enormously polygenic, with thousands of contributing variants with small effects, spread across much of the genome. These observations raise questions about why so many variants–and so many genes–impact any given phenotype. Here we consider a possible …

ch, us (code pays fourni par la source)

Author Response: Is competition for cellular resources a driver of complex trait heritability?

Olivier Naret, Yuval B. Simons, Jacques Fellay, Jonathan K. Pritchard

Most human complex traits are enormously polygenic, with thousands of contributing variants with small effects, spread across much of the genome. These observations raise questions about why so many variants–and so many genes–impact any given phenotype. Here we consider a possible model …

ch, us (code pays fourni par la source)

Fusion-negative rhabdomyosarcoma 3D organoids to predict effective drug combinations: A proof-of-concept on cell death inducers

Clara Savary, Léa Luciana, Paul Huchedé, Arthur Tourbez et autres

Rhabdomyosarcoma (RMS) is the main form of pediatric soft-tissue sarcoma. Its cure rate has not notably improved in the last 20 years following relapse, and the lack of reliable preclinical models has hampered the design of new therapies. This is particularly true …

fr, ch (code pays fourni par la source)

Reviewer #1 (Public Review): Is competition for cellular resources a driver of complex trait heritability?

Simons Yuval, Olivier Naret, Fellay Jacques, Pritchard Jonathan K

Most human complex traits are enormously polygenic, with thousands of contributing variants with small effects, spread across much of the genome. These observations raise questions about why so many variants–and so many genes–impact any given phenotype. Here we consider a possible model …

Reviewer #3 (Public Review): Is competition for cellular resources a driver of complex trait heritability?

Simons Yuval, Olivier Naret, Fellay Jacques, Pritchard Jonathan K

Most human complex traits are enormously polygenic, with thousands of contributing variants with small effects, spread across much of the genome. These observations raise questions about why so many variants–and so many genes–impact any given phenotype. Here we consider a possible model …

Is competition for cellular resources a driver of complex trait heritability?

Olivier Naret, Yuval B. Simons, Jacques Fellay, Jonathan K. Pritchard

Abstract Most human complex traits are enormously polygenic, with thousands of contributing variants with small effects, spread across much of the genome. These observations raise questions about why so many variants–and so many genes–impact any given phenotype. Here we consider a possible …

ch, us (code pays fourni par la source)

Is competition for cellular resources a driver of complex trait heritability?

Yuval B. Simons, Olivier Naret, Jacques Fellay, Jonathan K. Pritchard

Abstract Most human complex traits are enormously polygenic, with thousands of contributing variants with small effects, spread across much of the genome. These observations raise questions about why so many variants–and so many genes–impact any given phenotype. Here we consider a possible …

us, ch (code pays fourni par la source)

Reviewer #2 (Public Review): Is competition for cellular resources a driver of complex trait heritability?

Simons Yuval, Olivier Naret, Fellay Jacques, Pritchard Jonathan K

Most human complex traits are enormously polygenic, with thousands of contributing variants with small effects, spread across much of the genome. These observations raise questions about why so many variants–and so many genes–impact any given phenotype. Here we consider a possible model …

us, ch (code pays fourni par la source)

Genome-to-genome analysis reveals associations between human and mycobacterial genetic variation in tuberculosis patients from Tanzania

Zhi Ming Xu, Michaela Zwyer, Daniela Brites, Hellen Hiza et autres

Abstract The risk and prognosis of tuberculosis (TB) are affected by both human and bacterial genetic factors. To identify interacting human and bacterial genetic loci, we leveraged paired human and Mycobacterium tuberculosis ( M . tb ) genomic data from 1000 Tanzanian …

ch, Tanzanie (code pays fourni par la source)

G2GSnake: A Snakemake workflow for host-pathogen genomic association studies

Zhi Ming Xu, Olivier Naret, Jacques Fellay

Abstract Summary Joint analyses of paired host and pathogen genome sequences have the potential to enhance our understanding of host-pathogen interactions. A systematic approach to conduct such a joint analysis is through a “genome-to-genome” (G2G) association study, which involves testing for associations …

ch (code pays fourni par la source)