Timothy Dunn

Explainable 3D multi-scale movement quantification automates motor assessments and estimates Parkinson’s disease duration

Kyungdo Kim, Yuxuan Wen, Lauren Lim, Sihan Lyu et autres

Abstract Quantitative assessment of motor impairment in Parkinson’s disease (PD) remains limited, particularly in tracking how deficits evolve over time. Current bedside scoring systems, including the Movement Disorder Society Unified Parkinson’s Disease Rating Scale (MDS-UPDRS), capture clinically important observations but condense them …

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Liberata -- Graph Scientometrics for a Share Based System of Academic Publishing

Han Zhang, Anshuman Sabath, Timothy Dunn, L. Catherine Brinson

Contemporary scientometric indicators remain anchored in paradigms and axioms from when academic research was conducted in small scholarly communities. With the global proliferation of scientific research, academia is now organized in large communities with high rates of information incompleteness regarding work impact …

Liberata -- Graph Scientometrics for a Share Based System of Academic Publishing

Han Zhang, Anshuman Sabath, Timothy Dunn, L. Catherine Brinson

Contemporary scientometric indicators remain anchored in paradigms and axioms from when academic research was conducted in small scholarly communities. With the global proliferation of scientific research, academia is now organized in large communities with high rates of information incompleteness regarding work impact …

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Artificial Intelligence Prediction of Meningioma Grade Using Preoperative MRI: A Large Multicenter Study

Syed M. Adil, Tanner J. Zachem, Pranav I Warman, Jihad Abdelgadir et autres

Introduction: Accurate preoperative determination of meningioma grade could substantially enhance surgical planning, yet no reliable noninvasive method currently exists. This study aims to create and externally validate a machine learning model that integrates conventional radiomics with novel fractal and topological metrics to …

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Co-delivery of synaptogenic and angiogenic nanoparticles in MAP scaffolds enhances post-stroke synapse formation

Nhi Van Phan, Jeremy Lee Thomas, Aiden Pasinsky, Zoe Meadows et autres

Ischemic stroke remains one of the leading causes of long-term disability worldwide, depriving patients of their quality of life and physical independence. The root cause of this loss of motor movement stems from the disruption of neuronal connections in the infarct site. …

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VQ-MAP: a flexible, versatile framework for animal behavior understanding

Tianqing Li, Ugne Klibaite, Jumana F. Akoad, Joshua H Wu et autres

Abstract The brain generates behaviors that reflect configurations and computations of neural systems. Animal pose analysis can comprehensively profile behaviors in terms of stereotyped action expression, but the absence of common tracking standards makes it difficult to relate measurements across labs and …

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Trust Your Neighbors: Multimodal Patient Retrieval for TBI Prognosis

Pranav Manjunath, Brian Lerner, Timothy Dunn

Early and accurate triage of traumatic brain injury is critical for guiding treatment decisions that optimize patient outcomes. A major early clinical decision point occurs in the emergency department, where providers must decide whether to admit or discharge patients with head injuries, …

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Personalized Case- and Evidence-Based TBI Prognosis with Small Language Models

Pranav Manjunath, Syed M. Adil, Benjamin D. Wissel, Brian Lerner et autres

Timely and accurate emergency department disposition for traumatic brain injury patients requires rapid synthesis of complex, multimodal data. Yet in practice, such decisions often rely on heuristics, resulting in variable outcomes. While large language models show promise for supporting evidence-based practice, their …

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Cortex-Wide Substrates for Body Schema and Action Awareness

Kyle S. Severson, Jinghao Lu, Wenxi Xiao, Jiang He et autres

The concept of the body schema originated from studies of patients with cortical lesions who were unable to localize their body parts in space or perceive passive movements (Head & Holmes, 1911). Current consensus defines the body schema as the brain's internal …

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Delivery of Angiogenic Therapy from Flowable Hyaluronic Acid Porous Scaffolds Results in Functional Improvement without Anti‐Inflammatory Agents

Kevin Erning, Katrina L. Wilson, Cara S. Smith, Long Nguyen et autres

Ischemic stroke, a blockage in the vasculature of the brain that results in insufficient blood flow, is one of the world's leading causes of disability. The cascade of inflammation and cell death that occurs immediately following stroke drives vascular and functional loss …

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Mapping the landscape of social behavior

Ugne Klibaite, Tianqing Li, Diego Aldarondo, Jumana F. Akoad et autres

Social interaction is integral to animal behavior. However, lacking tools to describe it in quantitative and rigorous ways has limited our understanding of its structure, underlying principles, and the neuropsychiatric disorders, like autism, that perturb it. Here, we present a technique for …

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Clustered VEGF Nanoparticles in Microporous Annealed Particle (MAP) Hydrogel Accelerates Functional Recovery and Brain Tissue Repair after Stroke

Kevin Erning, Katrina L. Wilson, Cara S. Smith, Long Nguyen et autres

Ischemic stroke, a blockage in the vasculature of the brain that results in insufficient blood flow, is one of the world's leading causes of disability. The cascade of inflammation and cell death that occurs immediately following stroke drives vascular and functional loss …

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