Elliot M. Frohman

“Do You Hear What I Hear?” Speech and Voice Alterations in Hearing Loss: A Systematic Review

Arianna Di Stadio, Jake Sossamon, Pietro De Luca, Iole Indovina et autres

Background: Although hearing loss influences voice characteristics, such changes may be under-recognized during clinical consultations. This systematic review examines voice alterations in adults with post-lingual hearing loss, considering diagnostic and rehabilitative implications. Methods: A comprehensive search of PubMed, Scopus, and Google Scholar …

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Combining early lower eyelid surgery with neuromuscular retraining for synkinesis prevention after facial palsy: the role of the eye in aberrant facial nerve regeneration

Arianna Di Stadio, Massimo Ralli, Pietro De Luca, Jake Sossamon et autres

Background Facial synkinesis (FS) is a distressing sequela of facial palsy (FP) characterized by involuntary, simultaneous movements of facial muscles occurring during voluntary facial expressions. Treatment of synkinesis is challenging, and preventive methods are needed. Aim This study evaluated the efficacy of …

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Individual Prognostication of Disease Activity and Disability Worsening in Multiple Sclerosis With Retinal Layer Thickness z Scores

Ting‐Yi Lin, Seyedamirhosein Motamedi, Susanna Asseyer, Claudia Chien et autres

BACKGROUND AND OBJECTIVES: scores of OCT-derived measures to prognosticate future disease activity and disability worsening in people with MS (PwMS). METHODS: scores (pRNFL-z and GCIP-z) based on the reference data. Finally, we investigated the association of pRNFL-z or GCIP-z as predictors with …

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The bidirectional brain–cochlea axis: a scaffold for neurologic disease-associated hearing loss

Arianna Di Stadio, Elliot M. Frohman, Daniela Messineo, Michael Joel Brenner et autres

This scientific commentary refers to ‘Beyond the cochlea: exploring the multifaceted nature of hearing loss in primary mitochondrial diseases’, by Koohi et al. (https://doi.org/10.1093/braincomms/fcae374).

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Case study: Stomach ulcers in the context of tricuspid atresia—“I can barely stomach it”

Thomas Chandy Varkey, Chloe-Marie Lee Roeder, Rachel Elizabeth Daum, Sajana Ravi et autres

This case study focuses on the evaluation of a patient with both upper and lower gastrointestinal (GI) complaints in the outpatient setting, that is, how the evaluation skipped over several crucial diagnostic steps, and how this impacted the patient. Special care is …

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Neuroinflammatory disorders of the brain and inner ear: a systematic review of auditory function in patients with migraine, multiple sclerosis, and neurodegeneration to support the idea of an innovative ‘window of discovery’

Arianna Di Stadio, Pietro De Luca, Nehzat Koohi, Diego N. Kaski et autres

Background: of specific disorders. Auditory function can be measured by either subjective or objective tests. Objective tests are more useful in identifying which auditory pathway (superior or inferior) is most affected by disease. The inner ear's perilymphatic fluid communicates with the cerebrospinal …

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A Randomized Prospective Trial Comparing Repository Corticotropin Injection and Intravenous Methylprednisolone for Neuroprotection in Acute Optic Neuritis

Jeffrey L. Bennett, Nathan C. Grove, Ruth K. Johnson, Christopher Mizenko et autres

BACKGROUND: Repository corticotrophin injection (RCI, Acthar Gel) and intravenous methylprednisolone (IVMP) improve the rate but not the extent of visual recovery following acute optic neuritis. RCI has adrenal-stimulating and melanocortin receptor-stimulating properties that may endow it with unique anti-inflammatory properties relative to …

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Application of diagnostic criteria for optic neuritis – Authors' reply

Axel Petzold, Yaou Liu, Clare L. Fraser, Mathias H. Abegg et autres

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Optical coherence tomography angiography measurements in multiple sclerosis: a systematic review and meta-analysis

Soheil Mohammadi, Mahdi Gouravani, Mohammad Amin Salehi, J. Fernando Arévalo et autres

BACKGROUND AND OBJECTIVES: Recent literature on multiple sclerosis (MS) demonstrates the growing implementation of optical coherence tomography-angiography (OCT-A) to discover potential qualitative and quantitative changes in the retina and optic nerve. In this review, we analyze OCT-A studies in patients with MS …

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Targeting Neuroinflammation to Alleviate Chronic Olfactory Dysfunction in Long COVID: A Role for Investigating Disease-Modifying Therapy (DMT)?

Arianna Di Stadio, Evanthia Bernitsas, Ignazio La Mantia, Michael Joel Brenner et autres

Chronic olfactory dysfunction after SARS-CoV-2 infection occurs in approximately 10% of patients with COVID-19-induced anosmia, and it is a growing public health concern. A regimen of olfactory training and anti-neuroinflammatory therapy with co-ultramicronized palmitoylethanolamide with luteolin (um-PEA-LUT) has shown promising results in …

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A 'Whack-A-Mole' B cell Depletion Strategy Mitigates Alemtuzumab-Associated Secondary Autoimmunity: A Case Report & Literature Review

Juliana Mathias Netto Khouri, Jussara Mathias Netto Khouri, Ana Flávia Samways Guimaraes, Elliot M. Frohman et autres

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MOG Antibody–Associated Disease and Thymic Hyperplasia

Brigitte Hurtubise, Elliot M. Frohman, Steven L. Galetta, Laura J. Balcer et autres

Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a recently described CNS inflammatory disorder that may manifest with optic neuritis, myelitis, seizures, and/or acute disseminated encephalomyelitis. While MOG-specific antibodies in patients with MOGAD are IgG1, a T-cell-dependent antibody isotype, immunologic mechanisms of this …

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