Leila Eslamizar

Tailoring the Methods of Conjugation and Characterization for a Replication-Competent, Live, Viral Vector

Elise Ishida, Richard Dambra, Sally Ye, Steven Anderlot et autres

Optimized functionalization of virus particles can expand the toolbox available for the development of viral vector-based therapies. However, labeling of a large, complex, and biologically active particle introduces distinct technological challenges for subsequent purification and characterization steps. Moreover, the process of labeling …

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Recombinant MVA-prime elicits neutralizing antibody responses by inducing antigen-specific B cells in the germinal center

Leila Eslamizar, Constantinos Petrovas, David J. Leggat, Kathryn L. Furr et autres

Abstract The RV144 HIV-1 vaccine trial has been the only clinical trial to date that has shown any degree of efficacy and associated with the presence of vaccine-elicited HIV-1 envelope-specific binding antibody and CD4+ T-cell responses. This trial also showed that a …

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Structural Constraints of Vaccine-Induced Tier-2 Autologous HIV Neutralizing Antibodies Targeting the Receptor-Binding Site

Todd Bradley, Daniela Fera, Jinal N. Bhiman, Leila Eslamizar et autres

Antibodies that neutralize autologous transmitted/founder (TF) HIV occur in most HIV-infected individuals and can evolve to neutralization breadth. Autologous neutralizing antibodies (nAbs) against neutralization-resistant (Tier-2) viruses are rarely induced by vaccination. Whereas broadly neutralizing antibody (bnAb)-HIV-Envelope structures have been defined, the structures …

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Antigen-specific NK cell memory in rhesus macaques

R. Keith Reeves, Haiying Li, Stéphanie Jost, Eryn Blass et autres

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Inhibitory Effect of Individual or Combinations of Broadly Neutralizing Antibodies and Antiviral Reagents against Cell-Free and Cell-to-Cell HIV-1 Transmission

Randi B. Gombos, Dror Kolodkin‐Gal, Leila Eslamizar, Joshua O. Owuor et autres

UNLABELLED: To date, most therapeutic and vaccine candidates for human immunodeficiency virus type 1 (HIV-1) are evaluated preclinically for efficacy against cell-free viral challenges. However, cell-associated HIV-1 is suggested to be a major contributor to sexual transmission by mucosal routes. To determine …

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Optimization and qualification of an 8-color intracellular cytokine staining assay for quantifying T cell responses in rhesus macaques for pre-clinical vaccine studies

Mitzi M. Donaldson, Shing-Fen Kao, Leila Eslamizar, Connie E. Gee et autres

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Easily reversible desthiobiotin binding to streptavidin, avidin, and other biotin-binding proteins: uses for protein labeling, detection, and isolation

James D. Hirsch, Leila Eslamizar, Brian Filanoski, Nabi Malekzadeh et autres

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