Samuel J. Teener

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener et autres

OBJECTIVES: Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression. Here, we characterize markers of several neutrophil activation pathways and evaluate their associations with survival to identify potential mechanisms of disease. …

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Ketogenic Diet and Exercise Improve Peripheral Neuropathy in a Mouse Model of Metabolic Syndrome

Stéphanie Eid, Pongrat Jaisil, Kai Guo, John Mosely Hayes et autres

Metabolic syndrome (MetS) is a growing health concern that increases risk for peripheral neuropathy (PN), defined by nerve degeneration and sensory dysfunction. Although lifestyle strategies, like ketogenic diet (KD) and exercise, are known to mitigate MetS, their efficacy in maintaining nerve health …

Ketogenic Diet and Exercise Improve Peripheral Neuropathy in a Mouse Model of Metabolic Syndrome

Stéphanie Eid, Pongrat Jaisil, Kai Guo, John Mosely Hayes et autres

Metabolic syndrome (MetS) is a growing health concern that increases risk for peripheral neuropathy (PN), defined by nerve degeneration and sensory dysfunction. Although lifestyle strategies, like ketogenic diet (KD) and exercise, are known to mitigate MetS, their efficacy in maintaining nerve health …

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Ketogenic Diet and Exercise Improve Peripheral Neuropathy in a Mouse Model of Metabolic Syndrome

Stéphanie Eid, Pongrat Jaisil, Kai Guo, John Mosely Hayes et autres

Metabolic syndrome (MetS) is a growing health concern that increases risk for peripheral neuropathy (PN), defined by nerve degeneration and sensory dysfunction. Although lifestyle strategies, like ketogenic diet (KD) and exercise, are known to mitigate MetS, their efficacy in maintaining nerve health …

Natural Killer Cell Dysregulation During ALS Disease Progression

Stephen A. Goutman, Kai Guo, Jihyun Park, Dae-Gyu Jang et autres

Background and Objectives: Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neurodegenerative motor neuron disease with a pathophysiology that features dysregulated natural killer (NK) cells that are capable of damaging neurons. Although NK cells are associated with ALS progression and survival, …

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Glucose lowering treatment in high fat diet‐induced cognitive impairment indicates that cognitive deficits may be glucose independent

Sarah E. Elzinga, Diana M Rigan, Crystal M. Pacut, Samuel J. Teener et autres

BACKGROUND: The rates of metabolic stress (obesity, prediabetes, metabolic syndrome, and diabetes) are on the rise. Metabolic stress (particularly in midlife) increases the risk of later life cognitive impairment, including dementias such as Alzheimer's Disease and Alzheimer's Disease Related Dementias (AD/ADRD). Targeting …

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Tofacitinib extends survival in a mouse model of ALS through NK cell-independent mechanisms

Lillia A. Baird, Samuel J. Teener, Ian F. Webber‐Davis, Andrew Carter et autres

Background: Amyotrophic lateral sclerosis (ALS) is a lethal neurodegenerative disease with few treatment options, rendering the development of new, effective therapeutics of critical importance. The immune system plays a substantial role in ALS pathology, with multiple cell populations implicated in disease progression. …

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Gene expression signatures from whole blood predict amyotrophic lateral sclerosis case status and survival

Yue Zhao, Masha G. Savelieff, Xiayan Li, Kai Guo et autres

Amyotrophic lateral sclerosis (ALS) is a rare and fatal neurodegenerative disease with a median survival of only 2 to 4 years from diagnosis. Improved tools are needed to shorten diagnostic delays and improve prognostication to benefit clinical care. Herein, we profiled whole …

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Dietary and exercise interventions improve cognition and alter hippocampal transcriptomics in a mouse model of the metabolic syndrome

Pongrat Jaisil, Stéphanie Eid, Kai Guo, Masha G. Savelieff et autres

Metabolic syndrome (MetS) is a major global health concern that continues to rise in prevalence and further augments disease burden by predisposing individuals to cognitive impairment (CI). Managing MetS through lifestyle habits or interventions may prevent or improve CI. The ketogenic diet …

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In Vitro Modeling of Natural Killer Cell Cytotoxicity to Inform Personalized ALS Therapeutics

Benjamin J. Murdock, Jihyun Park, Dae‐Gyu Jang, Bangyao Zhao et autres

OBJECTIVE: Natural killer (NK) cells might contribute to motor neuron death in amyotrophic lateral sclerosis (ALS) through direct cytotoxicity, a process that could be inhibited with the FDA-approved JAK/STAT pathway inhibitor, tofacitinib. This study aimed to verify that tofacitinib can suppress NK …

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246-OR: Single Nuclei Multiome Sequencing Reveals Subtype-Specific Changes in Oligodendrocytes Imparted by the Metabolic Syndrome

Mohamed H. Noureldein, Sarah E. Elzinga, Bhumsoo Kim, Samuel J. Teener et autres

Introduction and Objective: One in three adults in the United States suffer from the metabolic syndrome (MetS). MetS is associated with neurological complications including cognitive impairments (such as Alzheimer’s Disease and its related Dementias), especially when compounded with aging. However, the mechanisms …

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194-OR: Sexually Dimorphic Microglial Senescence and Inflammatory Mechanisms in Obesity and Prediabetes Induced Cognitive Impairment

Sarah E. Elzinga, Kai Guo, Diana M Rigan, Samuel J. Teener et autres

Introduction and Objective: Rates of metabolic stress (obesity, prediabetes, metabolic syndrome, and diabetes) are increasing worldwide. Metabolic stress increases the risk of cognitive impairment, including dementias, with age. Immune system dysregulation/inflammation, including senescence-related inflammation, are common etiologies of metabolic stress, aging, and …