Andreas W. Sailer

Discovery and Optimization of Selective Inhibitors of Large Tumor Suppressor Kinases LATS1 and 2 for In Vivo Investigation of the Hippo-YAP Pathway in Tissue Regeneration

Kenji Namoto, Eric Vangrevelinghe, Rainer Machauer, Dirk Behnke et autres

Large Tumor Suppressor kinases LATS1 and 2 (LATS1/2) are serine/threonine kinases and core regulators of the Hippo-YAP pathway. Inhibition of LATS1/2 promotes nuclear translocation of nonphosphorylated YAP, thereby initiating a downstream cascade promoting cell proliferation. We set out to investigate the potential …

cn (code pays fourni par la source)

The ANKS3/BICC1 protein complex is a master post-transcriptional regulator of NPHP1 ciliopathy-gene transcripts

Alexia Mahuzier, Gweltas Odye, Valentina Grampa, Albane A. Bizet et autres

Abstract Ciliopathies are a class of multi-systemic genetic diseases characterized by ciliary dysfunction. Here, we report a novel ANKS3 variant in patients with a renal ciliopathy known as nephronophthisis (NPH) associated with hepatic defects. ANKS3 is an ankyrin and sterile alpha motif …

fr, de, ch (code pays fourni par la source)

NIBR-LTSi is a selective LATS kinase inhibitor activating YAP signaling and expanding tissue stem cells in vitro and in vivo

Kenji Namoto, Clara Baader, Vanessa Orsini, Alexandro Landshammer et autres

ch, de, us, mx, gb (code pays fourni par la source)

[Pestiviruses in sheep and goats in Austria: Options for integration into the bovine viral diarrhea (BVDV) monitoring program].

Andreas W. Sailer, Alice Wallner, M Haidegger, Michael Dünser

INTRODUCTION: After the successful eradication of the bovine viral diarrhea virus (BVDV) in cattle in Austria, the risk of infections with the border disease virus (BDV) remains. Both viruses belong to the pestivirus genus. BDV infections lead to false-positive results in BVDV …

Non‐invasive candidate protein signature predicts hepatic venous pressure gradient reduction in cirrhotic patients after sustained virologic response

Shola M. Richards, Fang Guo, Heng Zou, Florian Nigsch et autres

BACKGROUND AND AIMS: A reduction in hepatic venous pressure gradient (HVPG) is the most accurate marker for assessing the severity of portal hypertension and the effectiveness of intervention treatments. This study aimed to evaluate the prognostic potential of blood-based proteomic biomarkers in …

ch, es, us (code pays fourni par la source)

Interferon lambda activates the immunoproteasome thereby potentially regulating anti-viral immunity in the lung

Andreas W. Sailer, E Nößner, Silke Meiners

Interferons (IFN) are the first line of defense against pathogens such as viruses. Both, type I and II interferons induce the immunoproteasome in virally infected cells. The immunoproteasome degrades intracellular proteins - including viral ones - into small peptides for presentation on …

de (code pays fourni par la source)

Magnetic resonance elastography (MRE) demonstrate the strongest correlation with digital pathology and NASH CRN fibrosis assessments, compared to transient elastography and other assessed non-invasive tests (NITs)

Miljen Martić, Dean Tai, Nikolai V. Naoumov, Elaine Chng et autres

ch, sg, us, gb (code pays fourni par la source)

Second harmonic generation microscopy can quantify and subclassify early stages of NASH fibrosis progression: data from a screen-failure cohort of a NASH phase 2 study

Dominique Brees, Dean Tai, Clifford A. Brass, Nikolai V. Naoumov et autres

ZNRF3 and RNF43 cooperate to safeguard metabolic liver zonation and hepatocyte proliferation

Tianliang Sun, Stefano Annunziato, Sebastian Bergling, Caibin Sheng et autres

ch, it, us (code pays fourni par la source)

Publisher Correction: Gut-inhabiting Clostridia build human GPCR ligands by conjugating neurotransmitters with diet- and human-derived fatty acids

Fangyuan Chang, Piro Siuti, Stéphane Laurent, Thomas L. Williams et autres

us, ch (code pays fourni par la source)

EBI2 Is Temporarily Upregulated in MO3.13 Oligodendrocytes during Maturation and Regulates Remyelination in the Organotypic Cerebellar Slice Model

María Velasco‐Estevez, Nina Koch, Ilona Klejbor, Stéphane Laurent et autres

The EBI2 receptor regulates the immune system and is expressed in various immune cells including B and T lymphocytes. It is also expressed in astrocytes in the central nervous system (CNS) where it regulates pro-inflammatory cytokine release, cell migration and protects from …

pl, ch, ie (code pays fourni par la source)

Gut-inhabiting Clostridia build human GPCR ligands by conjugating neurotransmitters with diet- and human-derived fatty acids

Fangyuan Chang, Piro Siuti, Stéphane Laurent, Thomas L. Williams et autres

us, ch (code pays fourni par la source)