Glyn Barrett

Bioreceptive concrete for marine infrastructure with eco-friendly binders: a comprehensive review

Alexandra Gimblett, Glyn Barrett, Susan J. Hughes, Benyi Cao

Marine infrastructure and the ‘greying’ of coastlines are predicted to increase as it is necessary for transport, tourism, fishing, and protection. Concrete is often the main component used in marine infrastructure. There has been significant research into improving the performance of concrete …

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D-amino acid substitution and cyclization enhance the stability and antimicrobial activity of arginine-rich peptides

Bruno Mendes, Valeria Castelletto, Ian W. Hamley, Glyn Barrett

Cationic peptides, particularly those rich in arginine and/or lysine residues, are usually promising antimicrobial agents effective at low concentrations in laboratory settings. However, their applicability in pharmaceutics and biotechnology is currently limited due to their susceptibility to biological enzymatic processes and (in …

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Machine Learning-Guided Prediction of Formulation Performance in Inhalable Ciprofloxacin–Bile Acid Dispersions with Antimicrobial and Toxicity Evaluation

Tareq Zeyad Bahjat, Twana Mohammed M. Ways, Aram Ismael Ibrahim, Deon Danto et autres

High Resolution Image Download MS PowerPoint Slide Ciprofloxacin (CFX) is a potent antibiotic for respiratory infections, but its poor solubility and high crystallinity limit its effectiveness in dry powder inhaler (DPI) delivery. Although soluble forms such as CFX hydrochloride are available, their …

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Associations between local-scale soil and tree context factors and Acute Oak Decline (AOD): plant-soil feedbacks and the cause-effect conundrum

Liz J. Shaw, Mojgan Rabiey, Mateo San José, Toni‐Kim Clarke et autres

Abstract Background and aims Acute oak decline (AOD), a decline syndrome affecting mature oaks, involves bacterial pathogens which likely act as opportunists under host stress. Trees displaying symptoms (bleeding cankers) appear in localized clusters, not whole stands. This study investigates the potential …

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D-amino acid substitution and cyclisation enhance the stability and antimicrobial activity of arginine-rich peptides

Bruno Mendes, Valeria Castelletto, Ian W. Hamley, Glyn Barrett

ABSTRACT Cationic peptides rich in arginine are potent antimicrobials but face challenges due to enzymatic degradation and potential host toxicity. We screened eight linear arginine-rich peptides for antimicrobial and haemolytic activity, identifying R4F4 as the most active. However, its efficacy decreased in …

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Associations Between Local-Scale Soil and Tree Context Factors and Acute Oak Decline (AOD): Plant-Soil Feedbacks and the Cause-Effect Conundrum

Liz J. Shaw, Mojgan Rabiey, Mateo San Jose Garcia, Toni‐Kim Clarke et autres

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Correction to “Effect of Chirality and Amphiphilicity on the Antimicrobial Activity of Tripodal Lysine-Based Peptides”

Anindyasundar Adak, Valeria Castelletto, Lucas R. de Mello, Bruno Mendes et autres

The cause-effect conundrum of local-scale site and soil factors in acute oak decline (AOD)

Liz J. Shaw, Mojgan Rabiey, Toni‐Kim Clarke, Alice Broome et autres

Abstract Background and aims Acute oak decline (AOD), a decline syndrome affecting mature oaks, involves bacterial pathogens which likely act as opportunists under host stress. Trees displaying symptoms (bleeding cankers) appear in localized clusters, not whole stands. This study investigates the potential …

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Effect of Chirality and Amphiphilicity on the Antimicrobial Activity of Tripodal Lysine-Based Peptides

Anindyasundar Adak, Valeria Castelletto, Lucas R. de Mello, Bruno Mendes et autres

High Resolution Image Download MS PowerPoint Slide A series of tripodal (three-arm) lysine-based peptides were designed and synthesized and their self-assembly properties in aqueous solution and antimicrobial activity were investigated. We compare the behaviors of homochiral tripodal peptides (KKY) 3 K and …

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Diverse nanostructures and antimicrobial activity of lipopeptides bearing lysine-rich tripeptide sequences

Ian W. Hamley, Valeria Castelletto, Callum Rowding, C. Wilkinson et autres

-KXK analogues form bilayer nanotapes. The former show significant toxicity to bacteria in contrast to the latter, which we propose is due to the effect of the lipopeptide assembly curvature on induced bacterial membrane deformation.

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Innovative Microencapsulation of Polymyxin B for Enhanced Antimicrobial Efficacy via Coated Spray Drying

Amal Yousfan, Arwa Omar Al Khatib, Afrah M. H. Salman, Mahmoud H. Abu Elella et autres

High Resolution Image Download MS PowerPoint Slide This study aims to develop an innovative microencapsulation method for coated Polymyxin B, utilizing various polysaccharides such as hydroxypropyl β-cyclodextrin, alginate, and chitosan, implemented through a three-fluid nozzle (3FN) spray drying process. High-performance liquid chromatography …

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Chirality and pH Influence the Self-Assembly of Antimicrobial Lipopeptides with Diverse Nanostructures

Anindyasundar Adak, Valeria Castelletto, Bruno Mendes, Glyn Barrett et autres

High Resolution Image Download MS PowerPoint Slide Chirality plays a crucial role in the self-assembly of biomolecules in nature. Peptides show chirality-dependent conformation and self-assembly. Lipidation of peptides occurs in vivo and has recently been exploited in designed conjugates to drive self-assembly …

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