H. Jiang

HSBDF-Derived Bioactive Components Broadly Inhibit Enteroviruses by Targeting 3C Protease and Attenuating Inflammatory Responses

Ruolan Hu, Lin Guan, Siyue Li, Chunlin Liu et autres

Human enteroviruses are important pathogens of hand-foot-and-mouth disease, poliomyelitis, and encephalitis, etc., posing substantial global health burdens with no specific approved therapeutics. While traditional Chinese medicine (TCM) has demonstrated antiviral potential during the COVID-19 pandemic, its efficacy and pharmacodynamic material basis against …

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Ubiquitylation of cyclin C by HACE1 regulates cisplatin‐associated sensitivity in gastric cancer

H. Jiang, Ying‐ling Chen, Xingxing Xu, Chuan‐yin Li et autres

BACKGROUND: Cyclin C (CCNC) was reported to take part in regulating mitochondria-derived oxidative stress under cisplatin stimulation. However, its effect in gastric cancer is unknown. This study aimed to investigate the role of cyclin C and its ubiquitylation in regulating cisplatin resistance …

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Estrogen can reduce incidence of kidney stones by enhancing intestinal excretion of oxalate

Jing Gong, H. Jiang, Xuecheng Gao, J. Liu

Epithelial–mesenchymal transition in Crohn's disease

H. Jiang, Jun Shen, Zhi Hua Ran

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Neutrophil CD16b crosslinking induces lipid raft-mediated activation of SHP-2 and affects cytokine expression and retarded neutrophil apoptosis

Hao Yang, H. Jiang, Yu Song, Dingjiang Chen et autres

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Crystal structure of a metabolic reductase with (E)-5-((1-methyl-5-oxo-2-thioxoimidazolidin-4-ylidene)methyl)pyridin-2(1H)-one

Bing Zheng, Feng‐Ling Wu, H. Jiang, Masaya Kogiso et autres

Targeting PPM1D by lentivirus-mediated RNA interference inhibits the tumorigenicity of bladder cancer cells

W. Wang, Hongguang Zhu, Hao Zhang, Liwu Zhang et autres

Protein phosphatase magnesium/manganese-dependent 1D (PPM1D) is a p53-induced phosphatase that functions as a negative regulator of stress response pathways and has oncogenic properties. However, the functional role of PPM1D in bladder cancer (BC) remains largely unknown. In the present study, lentivirus vectors …

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Crystal structure of a metabolic reductase with 1-hydroxy-6-(4-hydroxybenzyl)-4-methylpyridin-2(1H)-one

Bing Song Zheng, Yang Yao, Zhao-Cheng Liu, Lin Deng et autres

Antimicrobial activities of the cinnamoyl amide of amino acid derivatives.

Qiliang Wei, H. Jiang, Junchen Zhang, C. Zhang et autres

Crystal structure of PPARgammaLBD complexed with the agonist magnolol

H. Zhang, Lingwen Chen, J. Chen, Liangdong Hu et autres

Babesia sp. EU1 Infection in a Forest Reindeer, the Netherlands

Yixing Li, Minghua Li, Shihong Fu, Weixin Chen et autres

Regio- and Stereoselective Difunctionalization of Alkynes

H. Jiang, Zhaogang Chen, Jun Li, Shiping Zhu et autres

Significance Terminal alkynes are readily available and widely used building blocks in organic synthesis. This publication describes a straight­forward transition-metal-catalyzed transformation of terminal alkynes into the corresponding ( Z )-β-haloenol acetates in a regio- and stereoselective manner using AgBF 4 as the …