Richard Rueda

Programmed DNA breaks drive chromatin reconfiguration and facilitate transcriptional potentiation at neuronal early response genes

Lance Heady, Richard Rueda, Amir Segev, Ram Madabhushi

ABSTRACT Neuronal activity causes topoisomerase IIβ (TOP2B) to form DNA double strand breaks (DSBs) within the promoters of key early response genes (ERGs), such as Fos and Npas4 . TOP2B-mediated DSBs facilitate rapid ERG transcription, yet how this occurs remains unclear. Here, …

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Author Correction: Gamma frequency entrainment attenuates amyloid load and modifies microglia

Hunter F. Iaccarino, Annabelle C. Singer, Anthony J. Martorell, Andrii Rudenko et autres

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Atypical Modes of CTCF Binding Facilitate Tissue-Specific and Neuronal Activity-Dependent Gene Expression States

Morgan Crewe, Amir Segev, Richard Rueda, Ram Madabhushi

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Calcineurin dephosphorylates topoisomerase IIβ and regulates the formation of neuronal-activity-induced DNA breaks

Ilse Delint‐Ramírez, Lahiri Konada, Lance Heady, Richard Rueda et autres

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Author Correction: Gamma frequency entrainment attenuates amyloid load and modifies microglia

Hannah F. Iaccarino, Annabelle C. Singer, Anthony J. Martorell, Andrii Rudenko et autres

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APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types

Yuan-Ta Lin, Jinsoo Seo, Fan Gao, Heather M. Feldman et autres

APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types

Yuan-Ta Lin, Jinsoo Seo, Fan Gao, Heather M. Feldman et autres

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The Transcription Factor Sp3 Cooperates with HDAC2 to Regulate Synaptic Function and Plasticity in Neurons

Hidekuni Yamakawa, Jemmie D. Cheng, Jay Penney, Fan Gao et autres

The histone deacetylase HDAC2, which negatively regulates synaptic gene expression and neuronal plasticity, is upregulated in Alzheimer's disease (AD) patients and mouse models. Therapeutics targeting HDAC2 hold promise for ameliorating AD-related cognitive impairment; however, attempts to generate HDAC2-specific inhibitors have failed. Here, …

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The Transcription Factor Sp3 Cooperates with HDAC2 to Regulate Synaptic Function and Plasticity in Neurons

Hidekuni Yamakawa, Jemmie D. Cheng, Jay Penney, Fan Gao et autres

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Gamma frequency entrainment attenuates amyloid load and modifies microglia

Hannah F. Iaccarino, Annabelle C. Singer, Anthony J. Martorell, Andrii Rudenko et autres

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Gamma frequency entrainment attenuates amyloid load and modifies microglia

Annabelle C. Singer, Anthony J. Martorell, Andrii Rudenko, Fan Gao et autres

Abstract Changes in gamma oscillations (20–50 Hz) have been observed in several neurological disorders. However, the relationship between gamma oscillations and cellular pathologies is unclear. Here we show reduced, behaviourally driven gamma oscillations before the onset of plaque formation or cognitive decline …

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Chd8 mediates cortical neurogenesis via transcriptional regulation of cell cycle and Wnt signaling

Omer Durak, Fan Gao, Yea Jin Kaeser‐Woo, Richard Rueda et autres

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