Hailin Tang

ITPKB suppresses ER calcium release to promote CXCL9 expression and enhance immunotherapy sensitivity in triple-negative breast cancer

Kejing Zhang, Xia Wang, Qiaoli Yi, Huajie Guan et autres

cn, us (code pays fourni par la source)

Dual targeting of ferroptosis and immune evasion: STAT3 inhibition as a one-two punch for breast cancer immunotherapy

Jianbo Zhou, Cailu Song, Zhi Tian, Hailin Tang et autres

cn, us (code pays fourni par la source)

ZBED6-driven nucleotide metabolic reprogramming improves sensitivity to anti-PD1 therapy in NK/T cell lymphoma

Cailu Song, Wenjian Liu, Xiaofang Xie, Cheng Peng et autres

cn (code pays fourni par la source)

ADSL drives fumarate mediated scrib-rictor complex formation to promote metastasis dissemination in triple-negative breast cancer

Yidan Fan, Xiaofang He, Wei Deng, Jianxiang Sun et autres

BACKGROUND: Triple-negative breast cancer (TNBC) is characterized by aggressive metastatic behavior and limited therapeutic options. Although metabolic reprogramming is increasingly recognized as a hallmark of TNBC, the mechanisms by which specific metabolic enzymes and intermediates drive metastasis remain poorly defined. METHODS: We …

cn (code pays fourni par la source)

Precision targeted therapy and immunotherapy in breast cancer: Advances and clinical frontiers

W Y Song, Pangzhou Chen, Wen Zhou, H T Wang et autres

ABSTRACT: Breast cancer remains the most common cancer among women worldwide, characterized by significant molecular heterogeneity. Advances in targeted therapy and immunotherapy have transformed treatment approaches, offering promising new options for patients. Targeted therapies are designed to inhibit the key pathways that …

cn, us (code pays fourni par la source)

Efficacy and safety of multiple treatments for small hepatocellular carcinoma: an updated systematic review and component network meta analysis

Peiyan Sun, Jianmin Wu, Dong Cai, Tianrun Lv et autres

Background: This is an updated component network meta-analysis to evaluate efficacy and safety of various therapeutic approaches and their combinations for small hepatocellular carcinoma (SHCC) following PRISMA 2020 guideline. Methods: We screened two previously published meta-analyses on this topic, and searched PubMed, …

cn (code pays fourni par la source)

Hijacking the bone niche: mechanistic insights into bone metastasis in breast cancer

J I A H U I Wu, Min Deng, Feng Ye, Wei Deng et autres

Breast cancer is one of the most common malignant tumors worldwide, with metastasis being the leading cause of mortality among patients. Bone is the most frequent site of metastasis in breast cancer, accounting for approximately 70% of metastatic cases. Before bone metastasis, …

cn (code pays fourni par la source)

A novel in vitro colorectal cancer model for investigating ABCB1- and ABCC1-mediated multidrug resistance

Harsh Patel, Yidong Li, Xuan- Yu Chen, Xiang Chen et autres

us, cn (code pays fourni par la source)

HO-1 Up-regulation and PINK1/Parkin-Mediated Mitophagy Contribute to the Anti-tumor Effects of Metochalcone in Colorectal Cancer

Pingting Chen, Junsha An, Mingyu Han, Yuhan Wang et autres

Colorectal cancer (CRC) remains a global health challenge with rising incidence in younger populations and limited efficacy of current chemotherapies. In this study, we investigated the anti-tumor mechanisms of metochalcone (MET), a natural chalcone derivative, in CRC. Using a combination of transcriptomic, …

cn (code pays fourni par la source)

Gymconopin C exhibits anti-non-small cell lung cancer effect by regulating miR-6777-5p/ADRB2 pathway to promote mitophagy

Xue Li, Mingyu Han, Limei Zhang, Xiaofang Xie et autres

• Firstly identifies Gymconopin C-a compound isolated from Bletilla striata-as a potent anti-NSCLC agent suppressing cancer development. • First evidence that miR-6777-5p/ADRB2 axis regulates PINK/Parkin-mediated mitophagy in NSCLC pathogenesis. • Elucidates the mechnistic cascade: Gymconopin C → miR-6777-5p ↓ →ADRB2 ↑ →PINK/Parkin …

cn (code pays fourni par la source)

Editorial: The insights of multi-omics into the microenvironment after tumor metastasis: a paradigm shift in molecular targeting modeling and immunotherapy for advanced cancer patients

Xuejian Liu, Qi Wang, Yang Ma, Xinhua Xiao et autres

Understanding the complex interplay within the tumor microenvironment (TME) following metastasis, using multi-omics technologies, is essential for revolutionizing treatments for advanced cancer. The post-metastatic TME is an intricate system of diverse cellular and molecular components (1). Integrating genomic, epigenomic, proteomic, and metabolomic …

cn, us, ae (code pays fourni par la source)

Figure S2 from circADAMTS12 Inhibits the Antitumor Activity of Microglia to Enable Metastatic Colonization in the Brain

Zhengmiao Xia, Weiguang Liu, Danni Guo, Long Chen et autres

CircADAMTS12 circulation-dead mutant to facilitate the production of linear transcripts of circADAMTS12