Eline S. Zwart

Pancreatic Cancer

Eline S. Zwart

This thesis examined various aspects of pancreatic cancer, both through clinical and translational research. The aim of this thesis was to deepen the understanding of the local and systemic tumor microenvironment of pancreatic cancer. In addition, this thesis examined whether resectability of …

Margin clearance greater than 1 mm in nodal-positive pancreatic adenocarcinoma patients: multicentre retrospective analysis

Reea Ahola, Eline S. Zwart, Benediktas Kurlinkus, Asif Halimi et autres

BACKGROUND: The introduction of the 1 mm cut-off for resection margin according to the Leeds Pathology Protocol has transformed the concept of surgical radicality. Its impact on nodal-positive resected pancreatic ductal adenocarcinoma patients is unclear. The aim of this study was to …

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In‐depth immune profiling of peripheral blood mononuclear cells in patients with pancreatic ductal adenocarcinoma reveals discriminative immune subpopulations

Ernesto Rodríguez, Eline S. Zwart, Alsya J. Affandi, Jan Verhoeff et autres

Abstract Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis with a 5‐year survival of less than 10%. More knowledge of the immune response developed in patients with PDAC is pivotal to develop better combination immune therapies to improve clinical outcome. In this …

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Spatial immune composition of tumor microenvironment in patients with pancreatic cancer

Eline S. Zwart, Thomas van Ee, Alsya J. Affandi, Lenka N.C. Boyd et autres

This study examined the composition of the immune microenvironment at different sites within resected pancreas specimens from patients with pancreatic ductal adenocarcinoma (PDAC). Therefore, single-cell suspensions were made from fresh tumor and non-tumorous tissue. Fourteen patients were included from whom twelve PDAC …

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The immune microenvironment after neoadjuvant therapy compared to upfront surgery in patients with pancreatic cancer

Eline S. Zwart, Thomas van Ee, Deesje Doppenberg, Arantza Fariña Sarasqueta et autres

Abstract Background Patients with resectable and borderline resectable pancreatic ductal adenocarcinoma increasingly receive neoadjuvant therapy prior to surgery. However, the effect of neoadjuvant therapy on the immune microenvironment remains largely unknown. We analyzed the immune microenvironment in pancreatic cancer tumor tissue samples …

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Factors that influence the pancreatic and duodenal microbiome in patients undergoing pancreatic surgery

Eline S. Zwart, Suzanne Jeleniewski, Lenka N.C. Boyd, Laura L. Meijer et autres

BACKGROUND/OBJECTIVES: This study examined the correlation between pancreatic microbiome and patients characteristics. Furthermore, we compared different duodenal materials to examine their reflection of the pancreatic microbiome. METHODS: Patients undergoing pancreatic surgery were included in the study. Characteristics of those patients were prospectively …

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Venous resection for pancreatic cancer, a safe and feasible option? A systematic review and meta-analysis

Eline S. Zwart, Bengi Su Yilmaz, Asif Halimi, Reea Ahola et autres

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The Diagnostic Value of the CA19-9 and Bilirubin Ratio in Patients with Pancreatic Cancer, Distal Bile Duct Cancer and Benign Periampullary Diseases, a Novel Approach

Lenka N.C. Boyd, Mahsoem Ali, Laura Kam, Jisce R. Puik et autres

Distinction of pancreatic ductal adenocarcinoma (PDAC) in the head of the pancreas, distal cholangiocarcinoma (dCCA), and benign periampullary conditions, is complex as they often share similar clinical symptoms. However, these diseases require specific management strategies, urging improvement of non-invasive tools for accurate …

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Factors that Influence the Pancreatic and Duodenal Microbiome in Patients Undergoing Pancreatic Surgery

Eline S. Zwart, S. Jeleniewski, Lenka N.C. Boyd, Laura L. Meijer et autres

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CD169 Defines Activated CD14+ Monocytes With Enhanced CD8+ T Cell Activation Capacity

Alsya J. Affandi, Katarzyna Olesek, Joanna Aleksandra Grabowska, Maarten K. Nijen Twilhaar et autres

Monocytes are antigen-presenting cells (APCs) that play diverse roles in promoting or regulating inflammatory responses, but their role in T cell stimulation is not well defined. In inflammatory conditions, monocytes frequently show increased expression of CD169/Siglec-1, a type-I interferon (IFN-I)-regulated protein. However, …

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De Novo Carcinoma after Solid Organ Transplantation to Give Insight into Carcinogenesis in General—A Systematic Review and Meta-Analysis

Eline S. Zwart, Esen Yüksel, Anne Pannekoek, Ralph de Vries et autres

Immunosuppressive therapy after solid organ transplantation leads to the development of cancer in many recipients. Analysis of the occurrence of different types of de novo carcinomas in relation to specific immunosuppressive drugs may give insight into their carcinogenic process and carcinogenesis in …

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In-depth immune profiling of peripheral blood mononuclear cells in pancreatic cancer patients

Eline S. Zwart, Ernesto Rodríguez, Jan Verhoeff, Alsya J. Affandi et autres

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