Huaqiang Zhou

A phase 2 study of encorafenib in combination with binimetinib for Chinese participants with BRAFV600E mutated metastatic non-small cell lung cancer: Results from the OCEAN II study

Huaqiang Zhou, Qing Zhou, Qisen Guo, Wei Guo et autres

Purpose The ongoing OCEAN II study (ClinicalTrials.gov identifier: NCT05195632) evaluates encorafenib in combination with binimetinib (E+B) in Chinese participants with BRAF V600E -mutated metastatic non-small cell lung cancer (NSCLC). Methods Participants with metastatic unresectable stage IV BRAF V600E -mutated NSCLC (treatment-naïve or …

cn, us, fr, de, gb (code pays fourni par la source)

Enhancing privacy-preserving deployable large language models for perioperative complication detection: a targeted strategy with LoRA fine-tuning

Shaowei Gao, Xu Zhao, Lihui Chen, Je‐Wook Yu et autres

Perioperative complications are a major global concern, yet manual detection suffers from 27% under‑reporting and frequent misclassification. Clinical LLM deployment is constrained by data sovereignty, compute cost, and limited locally deployable model performance. We show targeted prompt engineering plus Low‑Rank Adaptation (LoRA) …

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Spatiotemporal Niche Differentiation of Ungulates in the Southwest Mountains, China

Qingsong Jiang, Huaqiang Zhou, Ying Li, Jinghui Fu et autres

Spatiotemporal niche differentiation plays a critical role in facilitating mutual adaptation and sustaining coexistence among sympatric species. We investigated these patterns in sympatric ungulates through an infrared camera trap survey conducted in the Kazila Mountain region of southwestern China from July 2023 …

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Izalontamab brengitecan, an EGFR and HER3 bispecific antibody–drug conjugate, versus chemotherapy in heavily pretreated recurrent or metastatic nasopharyngeal carcinoma: a multicentre, randomised, open-label, phase 3 study in China

Yunpeng Yang, Huaqiang Zhou, Lin‐Quan Tang, Sufang Qiu et autres

cn, us (code pays fourni par la source)

Seasonal dynamics, dietary patterns, and bamboo leaf nutrition shape the phyllosphere-associated gut microbiota of red pandas

Liwen Kang, Yi Li, Jia Wang, Jinghui Fu et autres

BACKGROUND: The gut microbiota of bamboo-eating red pandas (Ailurus fulgens) comprises a intricate and multifaceted ecosystem influenced by numerous factors. Despite considerable research dedicated to captive red pandas, the microbial dynamics observed in wild populations are still not well understood. To address …

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EP.13.35 Sequential Atezolizumab Regimens (Chemo Followed by Anlotinib) for ES-SCLC: Real-World Data

Qian Xu, Huaqiang Zhou, Hongmeng Yu, Weizhong Jin et autres

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Efficacy and safety of perioperative, adjuvant and neoadjuvant chemoimmunotherapy stratified by clinical stage and PD-L1 expression in resectable non-small cell lung cancer: a systematic review and network meta-analysis

Yuanyuan Wang, Lin Zhang, Xinyuan Zhao, Dongchen Sun et autres

Background: IIIA-IIIB) and programmed cell death ligand 1 (PD-L1) expression. Methods: A systematic literature search was conducted through PubMed, Embase, ClinicalTrials.gov, and the Cochrane Central Register of Controlled Trials up to April 1, 2025. Relevant conference proceedings were also included. Randomized controlled …

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1097P Senaparib monotherapy for patients (pts) with BRCA1/2 mutated recurrent platinum-sensitive ovarian cancer (PSOC): Final analysis of study SABRINA

Xiaojie Wu, Haibo Liu, Lei Wang, Zuan Lin et autres

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LBA35 Iza-Bren (BL-B01D1), an EGFR×HER3 bispecific antibody-drug conjugate, versus physician's choice of chemotherapy in heavily pretreated recurrent/metastatic nasopharyngeal carcinoma: A randomized, open-label, multicenter, phase III, pivotal study (BL-B01D1-303)

Huaqiang Zhou, Yuan Yang, L.Q. Tang, Shi Guang Qiu et autres

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The Temporal and Spatial Responses of Large and Medium Mammals to Anthropogenic Disturbances in Montane Southwest China

Qiuxian Li, Xinyu Cui, Qingsong Jiang, Assan Meshach et autres

Humans, as super predators, influence wildlife behavior through both direct predation and indirect fear effects, prompting spatial and temporal adaptations. In landscapes where human-wildlife coexistence is prevalent, understanding the spatiotemporal strategies employed by rare wildlife in response to anthropogenic disturbance is essential …

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Baseline tumor burden predicts the efficacy of first-line chemoimmunotherapy in patients with advanced non-small cell lung cancer: results from 2 phase 3 randomized placebo-controlled trials

Xinyi He, Mengting Shi, Lin Zhang, Jianhua Zhan et autres

BACKGROUND: Baseline tumor burden (TB), measured radiographically, has emerged as a potential biomarker for stratifying survival outcomes with immune checkpoint inhibitors (ICI) across solid tumors. However, the predictive value for ICI plus chemotherapy (chemoimmunotherapy) in NSCLC has not been confirmed with large …

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Iparomlimab and tuvonralimab (QL1706) plus chemotherapy and bevacizumab for EGFR-mutant patients with advanced non-small cell lung cancer after failure of EGFR-tyrosine kinase inhibitors: updated results from cohort 5 in the DUBHE-L-201 study

Yaxiong Zhang, Yan Huang, Yunpeng Yang, Yuanyuan Zhao et autres

Iparomlimab and tuvonralimab (QL1706), a bifunctional anti-programmed death-1/cytotoxic T-lymphocyte antigen-4 antibody, in combination with bevacizumab and doublet chemotherapy was tolerable and showed preliminary antitumor activity in advanced non-small cell lung cancer (NSCLC) in DUBHE-L-201 study. Here, we report the updated data of …

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